|July 29, 2004|
|Life Extension Update Exclusive |
Resveratrol works on roundworms and fruit flies, too
Resveratrol is one of several compounds that activate Sir2-like proteins (known as sirtuins), which have been found to be active in calorie-restricted organisms. Greater sirtuin activity within a cell is associated with increased survival. In the current series of experiments, Sinclair and colleagues demonstrate that sirtuin activating compounds increase the in vitro activity of Sir-2.1 and Sir2 purified from the roundworm and the fruit fly. In further experiments, the team administered diets with or without resveratrol to roundworms and observed an extension of lifespan of up to 14 percent in worms who received the compound compared to the control group.
When the effect of resveratrol was examined in fruit flies on abundant diets, the lifespan of flies who received the compound was extended up to 29 percent. While male and female flies on calorie restricted diets experienced an average extension of lifespan of 10 and 40 percent, respectively, the addition of resveratrol to the regimen did not increase longevity. The authors write that this finding “suggests that resveratrol extends lifespan through a mechanism related to calorie restriction.”
Interestingly, the female flies who received resveratrol experienced an increase in egg production, which contradicts other experimental findings that regimens that extend lifespan reduce fertility.
This research demonstrates in multicellular animals that it may be possible to elicit some of the benefits of calorie restriction without eating less by utilizing sirtuin-activating compounds such as resveratrol.
The following supplements are the most important in preventing the common diseases of aging:
Findings from published scientific literature indicates that resveratrol may be the most effective plant extract for maintaining optimal health.
Life Extension has added resveratrol and other plant extracts to the new I3C/Resveratrol combination capsule.
Resveratrol, an extract that comes from grapes, vines and other plants, has been found by researchers to possess certain properties that may be important in maintaining optimal health.
Having isolated this nutrient from organic red grapes, a standardized extract has been developed and combined with I3C to create one of the most useful nutrients in safeguarding one's health.
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