As people age, systemic inflammation can inflict degenerative effects throughout the body.1-5 A primary cause of this destructive cascade is the production of cell-signaling chemicals known as inflammatory cytokines. Along with these dangerous cytokines, imbalances of hormone-like messengers called prostaglandins also contribute to inflammatory processes.

Boswella is composed of boswellic acids, an extract of the resin of the Boswellia serrata tree which grows in India. Boswellic acids are effective at blocking the synthesis of pro-inflammatory 5-lipoxygenase products, including 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4), which cause bronchoconstriction, chemotaxis, and increased vascular permeability. Boswellic acids may also mediate their inflammatory actions by inhibiting cyclooxygenases, preferentially COX-1.59-67

In addition, the combination of boswellic acids and glucosamine may have a synergistic favorable effect on inflammatory conditions.68