Life Extension Blood Test Super Sale

Products

SAMe (S-adenosylmethionine)

200 mg 50 enteric coated tablets, Item# 00453

UNITS NON‑MEMBERS MEMBERS (not a member?)
1

Retail price

$36.00 each

Save 25%

$27.00 each

4

Save 11%

$32.00 each

Save 33%

$24.00 each

SAMe (S-adenosylmethionine)
200 mg 50 enteric coated tablets
Item Catalog Number:
00453

SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:

  • Methylation (contributing methyl groups to activate certain molecules)47,48
  • The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)49-51
  • Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)52-54

SAMe occurs naturally in the body. It is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, catecholamines, and other neurotransmitters, such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin, and also plays a role in other intracellular metabolic pathways.55,56 SAMe facilitates glutathione57,58 usage and maintains acetylcholine levels,59,60 which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.

SAMe levels may become depleted from sickness and age. Supplementation with the co-factors — folate, trimethylglycine (TMG or betaine), vitamins B6 and B12, together with SAMe — appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid, and is used in the brain to make the neurotransmitter acetylcholine.47,50,61

In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Its findings show the efficacy of SAMe in helping to maintain stable mood and joint function without any side effects.62 Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older.49,60,63-66 In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione.57,58,67 When liver function is compromised, glutathione is depleted, which leads to free radical damage.

References
Supplement Facts

Serving Size 2 tablets

Servings Per Container 25

Amount Per Serving

S-Adenosyl-Methionine

400 mg

Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, stearic acid, silica, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, titanium dioxide, yellow ochre.

Dosage and Use
  • Take two tablets two to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner.
  • Take with co-factors vitamins B12, B6, and folic acid.
Caution

SAMe should not be taken by those diagnosed with bipolar disorder.

Warnings

REVIEW SNAPSHOT®

by PowerReviews
Life ExtensionSAMe (S-adenosylmethionine), 200 mg 50 enteric coated tablets
 
4.7

(based on 15 reviews)

Ratings Distribution

  • 5 Stars

     

    (11)

  • 4 Stars

     

    (4)

  • 3 Stars

     

    (0)

  • 2 Stars

     

    (0)

  • 1 Stars

     

    (0)

100%

of respondents would recommend this to a friend.

Pros

  • Simple to take (14)
  • Produces results (12)
  • No side effects (11)
  • Acts quickly (6)

Cons

    Best Uses

    • Daily use (14)
    • Women (9)
    • Men (8)
    • Older people (7)
      • Reviewer Profile:
      • Health conscious (11), Regular user (9), Medical professional (4), First time user (3)

    Reviewed by 15 customers

    Sort by

    Displaying reviews 1-10

    Back to top

    Previous | Next »

     
    5.0

    My staple SAMe

    By kakai

    from VT

    About Me Health Conscious

    See all my reviews

    Verified Reviewer

    Pros

    • Convenient packaging
    • Easy On Stomach
    • Easy To Swallow
    • Effective
    • Good Value
    • Simple To Take

    Cons

      Best Uses

      • Daily Use
      • Men
      • Women

      Comments about Life Extension SAMe (S-adenosylmethionine), 200 mg 50 enteric coated tablets:

      I take SAMe 200 mg. 3x daily because I can't make it on my own. The 200 mg. size works perfectly with Life Extension's multi, which I also take 3x daily. Because I am extremely sensitive to the balance of nutrients, the proportions are crucial. I also find the bottle is much more convenient than individual packaging and does not effect the quality even under moist conditions.

      Comment on this review

       
      5.0

      Consistant performance

      By Lainie

      from Magnolia, TX

      About Me Health Conscious, Regular User

      See all my reviews

      Pros

      • No Side Effects
      • Produces Results
      • Simple To Take

      Cons

        Best Uses

        • Daily Use
        • Men
        • Older People
        • Women

        Comments about Life Extension SAMe (S-adenosylmethionine), 200 mg 50 enteric coated tablets:

        My husband has used this for years with no apparent side effects. We recently increased the dosage for improved joint function, with no ill effects.

        Comment on this review

         
        5.0

        sleep better

        By Diana

        from wasington state

        About Me Health Conscious, Regular User

        Pros

        • Produces Results
        • Simple To Take

        Cons

        • None

        Best Uses

        • Daily Use

        Comments about Life Extension SAMe (S-adenosylmethionine), 200 mg 50 enteric coated tablets:

        I have much improved sleep taking SAMe

        Comment on this review

         
        5.0

        SAMe is effective for me

        By Freddy G

        from Asbury Park NJ

        About Me Health Conscious, Regular User

        See all my reviews

        Pros

        • Acts Quickly
        • No Side Effects
        • Produces Results
        • Simple To Take

        Cons

          Best Uses

          • Daily Use
          • Men
          • Older People
          • Women

          Comments about Life Extension SAMe (S-adenosylmethionine), 200 mg 50 enteric coated tablets:

          SAMe helps maintain my mood and energy

          Comment on this review

           
          4.0

          Great Price For Quality SAMe Product

          By Reviewer

          from Ohio

          About Me Health Conscious, Regular User

          See all my reviews

          Pros

          • No Side Effects
          • Simple To Take

          Cons

            Best Uses

            • Daily Use

            Comments about Life Extension SAMe (S-adenosylmethionine), 200 mg 50 enteric coated tablets:

            Very good price on a quality SAMe product. Blister packs may be the better option for optimal freshness but the bottle is more affordable and often available during overstock sales. 200mg tablets make it easy to scale the dosage for your needs.

            Comment on this review

             
            4.0

            "blues" are gone

            By vc

            from Macomb, MI

            About Me First Time User, Medical Professional

            Pros

            • No Side Effects
            • Produces Results
            • Simple To Take
            • Takes a few weeks to work

            Cons

              Best Uses

              • Daily Use

              Comments about Life Extension SAMe (S-adenosylmethionine), 200 mg 50 enteric coated tablets:

              This product calms mind and relieves stress without any side effects. It may take a few weeks before full benefits are seen.

              Comment on this review

              (0 of 1 customers found this review helpful)

               
              4.0

              Excellent product

              By Deb

              from California

              About Me Health Conscious, Medical Professional, Regular User

              See all my reviews

              Pros

              • Acts Quickly
              • No Side Effects
              • Produces Results
              • Simple To Take

              Cons

                Best Uses

                • Daily Use
                • Men
                • Older People
                • Women

                Comments about Life Extension SAMe (S-adenosylmethionine), 200 mg 50 enteric coated tablets:

                LEF Same is the best product

                Comment on this review

                (0 of 1 customers found this review helpful)

                 
                4.0

                Excellent product

                By Deb

                from California

                About Me Health Conscious, Medical Professional, Regular User

                See all my reviews

                Pros

                • Acts Quickly
                • No Side Effects
                • Produces Results
                • Simple To Take

                Cons

                  Best Uses

                  • Daily Use
                  • Men
                  • Older People
                  • Short-Term Solution
                  • Women

                  Comments about Life Extension SAMe (S-adenosylmethionine), 200 mg 50 enteric coated tablets:

                  LEF Same is the best I have used on the market

                  Comment on this review

                   
                  5.0

                  I would buy this product again and again

                  By mr mike

                  from charleston sc

                  About Me Regular User

                  Pros

                  • Acts Quickly
                  • No Side Effects
                  • Produces Results
                  • Simple To Take

                  Cons

                    Best Uses

                    • Daily Use

                    Comments about Life Extension SAMe (S-adenosylmethionine), 200 mg 50 enteric coated tablets:

                    As a 5 year daily user, I use it to improve my liver function. In the beginning, I took one 200 mg tablet each morning. When the price went down, I began taking two 200 mg tablets in the morning. Now that I've found it on a super sale, I take two 200 mg tabs 3 times a day. I believe that it greatly helps my liver function . I highly recommend it and I will probably take it for the rest of my life.

                    Comment on this review

                     
                    5.0

                    A powerful weapon in my health arsenal!

                    By Dee, a satisfied customer

                    from Tampa, FL

                    About Me Health Conscious

                    Pros

                    • Acts Quickly
                    • No Side Effects
                    • Produces Results
                    • Simple To Take

                    Cons

                      Best Uses

                      • Daily Use
                      • Men
                      • Older People
                      • Women

                      Comments about Life Extension SAMe (S-adenosylmethionine), 200 mg 50 enteric coated tablets:

                      This product enables me to live an active lifestyle with much less discomfort and an improved mood. I take it on a daily basis.

                      Comment on this review

                      Displaying reviews 1-10

                      Back to top

                      Previous | Next »