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SAMe (S-Adenosyl-Methionine)

400 mg 20 enteric coated tablets , Item# 00557

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SAMe (S-Adenosyl-Methionine)
400 mg 20 enteric coated tablets
Item Catalog Number:
00557

SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:

  • Methylation (contributing methyl groups to activate certain molecules)47,48
  • The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)49-51
  • Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)52-54

SAMe occurs naturally in the body. It is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, catecholamines, and other neurotransmitters, such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin, and also plays a role in other intracellular metabolic pathways.55,56 SAMe facilitates glutathione57,58 usage and maintains acetylcholine levels,59,60 which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.

SAMe levels may become depleted from sickness and age. Supplementation with the co-factors — folate, trimethylglycine (TMG or betaine), vitamins B6 and B12, together with SAMe — appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid, and is used in the brain to make the neurotransmitter acetylcholine.47,50,61

In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Its findings show the efficacy of SAMe in helping to maintain stable mood and joint function without any side effects.62 Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older.49,60,63-66 In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione.57,58,67 When liver function is compromised, glutathione is depleted, which leads to free radical damage.

References
Supplement Facts

Serving Size 1 tablet

Servings Per Container 20

Amount Per Serving

S-Adenosyl-Methionine

400 mg

Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, silica, stearic acid, glyceryl triacetate, sodium starch glycolate, crosarmellose sodium, titanium dioxide, yellow ochre.

Dosage and Use
  • Take one tablet two to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner.
  • Take with co-factors vitamins B12, B6, and folic acid.
Caution

SAMe should not be taken by those diagnosed with bipolar disorder.

Warnings

REVIEW SNAPSHOT®

by PowerReviews
Life ExtensionSAMe (S-Adenosyl-Methionine), 400 mg 20 enteric coated tablets
 
4.7

(based on 9 reviews)

Ratings Distribution

  • 5 Stars

     

    (6)

  • 4 Stars

     

    (3)

  • 3 Stars

     

    (0)

  • 2 Stars

     

    (0)

  • 1 Stars

     

    (0)

100%

of respondents would recommend this to a friend.

Pros

  • Simple to take (7)
  • Produces results (6)
  • No side effects (5)

Cons

    Best Uses

    • Daily use (8)
    • Men (5)
    • Older people (3)
    • Women (3)
      • Reviewer Profile:
      • Health conscious (8), Regular user (8)

    Reviewed by 9 customers

    Sort by

    Displaying reviews 1-9

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    5.0

    It works for me!

    By Suz

    from Turlock, CA

    About Me Health Conscious, Regular User

    Pros

    • Acts Quickly
    • Good Taste
    • No Side Effects
    • Produces Results
    • Simple To Take

    Cons

      Best Uses

      • Daily Use
      • Men
      • Older People
      • Women

      Comments about Life Extension SAMe (S-Adenosyl-Methionine), 400 mg 20 enteric coated tablets:

      I'd had some joint issues for longer than I care to admit, and was experiencing irritability as a side effect of a medication. A few weeks after starting SAMe, I realized my joints feel normal, and my moods are much better. I hoped it would work, but this has exceeded my expectations.

      Comment on this review

       
      5.0

      this works as claimed

      By Joe C

      from Staten Island

      About Me Health Conscious

      Pros

      • Simple To Take

      Cons

        Best Uses

        • Men

        Comments about Life Extension SAMe (S-Adenosyl-Methionine), 400 mg 20 enteric coated tablets:

        I started taking Sam e for joint health and found it worked well as a antidepressant

        Comment on this review

        (2 of 2 customers found this review helpful)

         
        5.0

        Excellent product.

        By Lin

        from Wisconsin

        About Me Health Conscious, Regular User

        Pros

        • No Side Effects
        • Produces Results
        • Simple To Take

        Cons

          Best Uses

          • Daily Use
          • Men
          • Older People
          • Women

          Comments about Life Extension SAMe (S-Adenosyl-Methionine), 400 mg 20 enteric coated tablets:

          No stomach discomfort (as found with other brands). Produces results.

          Comment on this review

           
          4.0

          Been using this for many years

          By Eagleyes

          from Granada Hills (L.A.),CA

          About Me Regular User

          See all my reviews

          Pros

          • Simple To Take

          Cons

            Best Uses

            • Daily Use

            Comments about Life Extension SAMe (S-Adenosyl-Methionine), 400 mg 20 enteric coated tablets:

            I can't quantify the results, but it seems to help with mood.

            Comment on this review

             
            4.0

            Seems to work

            By Eagleyes

            from Granada Hills (L.A.),CA

            About Me Health Conscious, Regular User

            See all my reviews

            Pros

            • No Side Effects
            • Simple To Take

            Cons

              Best Uses

              • Daily Use

              Comments about Life Extension SAMe (S-Adenosyl-Methionine), 400 mg 20 enteric coated tablets:

              Product seems to have a positive effect on mood, but without a clinical trial I have no way of really knowing.

              Service and delivery comments:

              Delivery and cust. service is excellent.

              Comment on this review

              (3 of 3 customers found this review helpful)

               
              4.0

              Very consistent quality and results

              By kenneth

              from Chicago, IL

              About Me Health Conscious, Regular User

              Pros

              • Acts Quickly
              • Produces Results

              Cons

                Best Uses

                • Daily Use
                • Men

                Comments about Life Extension SAMe (S-Adenosyl-Methionine), 400 mg 20 enteric coated tablets:

                I've wrestled with mild to moderate blues for years, and it greatly intensifies in the winter months. I find 400 mg of SAMe is the perfect solution for me, or at least the foundation of one. I feel the results within a week or two. Sometimes I augment it with selegeline/phenylalanine or tianeptine, but it's a good solid option by itself, and one with virtually no side effects relative to the prescription drugs out there. Unless you have some obvious contraindication, SAMe is an excellent option to explore.

                My only gripe, and a modest one, is price. I know it's come down dramatically over the years, but probably not as much as it could. If it's like Q-10, the market is probably pretty controlled by producers, but if the quality is there, I can't complain too bitterly.

                Comment on this review

                (3 of 3 customers found this review helpful)

                 
                5.0

                SAMe - changed my life

                By Cherie

                from Bothell, WA

                About Me Health Conscious, Regular User

                Pros

                • Produces Results

                Cons

                  Best Uses

                  • Daily Use
                  • Men
                  • Older People
                  • Women

                  Comments about Life Extension SAMe (S-Adenosyl-Methionine), 400 mg 20 enteric coated tablets:

                  I take 400mg each morning after I eat. I know this product works because when I went five days without it I started having joint inflammation, sciatic nerve irritation, and my level of patience with every day life changed. When I started taking the product, again, all of the symptoms I described disappeared. I tried SAMe a couple of times from sources other than Life Extension, only to return to LEF. LEF's SAMe is much more effective than other brands. My quality of life has been changed because of LEF's SAMe. I highly recommend this product, and do not go a day without it!

                  Comment on this review

                   
                  5.0

                  This product really works for me

                  By health nut

                  from colorado

                  About Me Health Conscious, Regular User

                  Pros

                  • No Side Effects
                  • Produces Results
                  • Simple To Take

                  Cons

                    Best Uses

                    • Daily Use

                    Comments about Life Extension SAMe (S-Adenosyl-Methionine), 400 mg 20 enteric coated tablets:

                    Sam E helps my mood greatly.

                    Comment on this review

                     
                    5.0

                    SAMe

                    By Nan

                    from Fort Collins, CO

                    About Me Health Conscious, Regular User

                    Pros

                    • No Side Effects
                    • Produces Results
                    • Simple To Take

                    Cons

                      Best Uses

                      • Daily Use

                      Comments about Life Extension SAMe (S-Adenosyl-Methionine), 400 mg 20 enteric coated tablets:

                      I use SAMe daily. This product makes a big difference for mood and brain function for me. I notice a huge difference without it! Additionally, I have confidence in the quality and potency of Life Extension's products.

                      Comment on this review

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