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SAMe (S-adenosyl-methionine)

400 mg 50 enteric coated tablets, Item# 01055

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SAMe (S-adenosyl-methionine)
400 mg 50 enteric coated tablets
Item Catalog Number:
01055

SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:

  • Methylation (contributing methyl groups to activate certain molecules)47,48
  • The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)49-51
  • Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)52-54

SAMe occurs naturally in the body. It is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, catecholamines, and other neurotransmitters, such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin, and also plays a role in other intracellular metabolic pathways.55,56 SAMe facilitates glutathione57,58 usage and maintains acetylcholine levels,59,60 which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.

SAMe levels may become depleted from sickness and age. Supplementation with the co-factors — folate, trimethylglycine (TMG or betaine), vitamins B6 and B12, together with SAMe — appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid, and is used in the brain to make the neurotransmitter acetylcholine.47,50,61

In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Its findings show the efficacy of SAMe in helping to maintain stable mood and joint function without any side effects.62 Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older.49,60,63-66 In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione.57,58,67 When liver function is compromised, glutathione is depleted, which leads to free radical damage.

References
Supplement Facts

Serving Size 1 tablet

Servings Per Container 50

Amount Per Serving

S-Adenosyl-Methionine

400 mg

Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, silica, stearic acid, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, titanium dioxide, yellow ochre.

Dosage and Use
  • Take one tablet two to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practioner.
  • Take with co-factors vitamins B12, B6, and folic acid.
Caution

SAMe should not be taken by those diagnosed with bipolar disorder.

Warnings

REVIEW SNAPSHOT®

by PowerReviews
Life ExtensionSAMe (S-adenosyl-methionine), 400 mg 50 enteric coated tablets
 
4.4

(based on 13 reviews)

Ratings Distribution

  • 5 Stars

     

    (8)

  • 4 Stars

     

    (4)

  • 3 Stars

     

    (0)

  • 2 Stars

     

    (0)

  • 1 Stars

     

    (1)

100%

of respondents would recommend this to a friend.

Pros

  • Produces results (9)
  • Simple to take (9)
  • No side effects (7)
  • Acts quickly (6)
  • Good taste (5)

Cons

    Best Uses

    • Daily use (12)
    • Older people (5)
      • Reviewer Profile:
      • Health conscious (11), Regular user (8)

    Most Liked Positive Review

     

    SAMe evens me out

    I have been taking SAMe for five years and specifically Life Extensions brand for the last two years. In the past my only compliant with SAMe was that if I skipped a day, I...Read complete review

    I have been taking SAMe for five years and specifically Life Extensions brand for the last two years. In the past my only compliant with SAMe was that if I skipped a day, I would get pains in my head. With the Life Extension brand I have not experienced this although I rarely ever skip.

    SAMe takes the edge off and evens me out.

    VS

    Most Liked Negative Review

     

    Contains GMOs

    Great product that really works but it comes at a cost in my opinion. I think it contains too many ingredients first off but most importantly this product contains GMOs. I haven't stopped purchasing...Read complete review

    Great product that really works but it comes at a cost in my opinion. I think it contains too many ingredients first off but most importantly this product contains GMOs. I haven't stopped purchasing this product yet since I'm actively looking for a healthier replacement that doesn't contain GMOs.

    Reviewed by 13 customers

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    Displaying reviews 1-10

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    (2 of 2 customers found this review helpful)

     
    5.0

    bounce back in my step

    By Kristie R

    from Hollywood, SC

    About Me Health Conscious

    Pros

    • Easy on Stomach
    • Easy To Swallow
    • Effective

    Cons

      Best Uses

      • Daily Use

      Comments about Life Extension SAMe (S-adenosyl-methionine), 400 mg 50 enteric coated tablets:

      When my husband and I run out of SAMe we notice we are a bit melancholy. Once we start back on the supplement the spring is back in our steps.

      Comment on this review

       
      4.0

      SAME

      By Natalia

      from Bergen County, NJ

      About Me Health Conscious

      Pros

      • Effective
      • Simple To Take

      Cons

        Best Uses

        • Daily Use

        Comments about Life Extension SAMe (S-adenosyl-methionine), 400 mg 50 enteric coated tablets:

        I workout daily and use the same for my joints.
        It provides me the with additional flexibility.

        Comment on this review

        (2 of 2 customers found this review helpful)

         
        1.0

        Contains GMOs

        By Randy

        from Aliso Viejo, CA

        About Me Health Conscious

        Verified Buyer

        Pros

        • Effective

        Cons

          Best Uses

            Comments about Life Extension SAMe (S-adenosyl-methionine), 400 mg 50 enteric coated tablets:

            Great product that really works but it comes at a cost in my opinion. I think it contains too many ingredients first off but most importantly this product contains GMOs. I haven't stopped purchasing this product yet since I'm actively looking for a healthier replacement that doesn't contain GMOs.

            Comment on this review

             
            5.0

            I have bought this for years!

            By Lainie

            from Magnolia, TX

            About Me Health Conscious, Regular User

            See all my reviews

            Pros

            • Acts Quickly
            • Good Taste
            • No Side Effects
            • Produces Results
            • Simple To Take

            Cons

              Best Uses

              • Daily Use
              • Older People

              Comments about Life Extension SAMe (S-adenosyl-methionine), 400 mg 50 enteric coated tablets:

              Works like the information says it does.

              Comment on this review

               
              5.0

              Permanent part of my daily supplements

              By cgresearcher

              from long island, new york

              About Me Health Conscious, Regular User

              See all my reviews

              Pros

              • Produces Results
              • Simple To Take

              Cons

                Best Uses

                • Daily Use
                • Older People

                Comments about Life Extension SAMe (S-adenosyl-methionine), 400 mg 50 enteric coated tablets:

                SAMe has become a permanent part of my daily supplement regime. I feel better all the way around when I take it.

                Comment on this review

                 
                4.0

                SAMe (Sadenosyl-methionine)

                By sonny

                from Philadelphia, Pa.

                About Me First Time User

                Pros

                • Acts Quickly
                • No Side Effects
                • Produces Results

                Cons

                • Results Lessen Over Time

                Best Uses

                • Daily Use
                • Men
                • Older People

                Comments about Life Extension SAMe (S-adenosyl-methionine), 400 mg 50 enteric coated tablets:

                Very good product and I recomend it.

                Comment on this review

                (2 of 2 customers found this review helpful)

                 
                4.0

                SAMe

                By Raymour & Flannigan

                from NYC

                About Me Health Conscious, Regular User

                See all my reviews

                Pros

                • Good Taste
                • No Side Effects
                • Simple To Take

                Cons

                  Best Uses

                  • Daily Use

                  Comments about Life Extension SAMe (S-adenosyl-methionine), 400 mg 50 enteric coated tablets:

                  The 200mg version are better value.

                  Comment on this review

                  (2 of 2 customers found this review helpful)

                   
                  5.0

                  I have been using this product for years

                  By Joy

                  from San Diego, Ca.

                  About Me Health Conscious, Regular User

                  Pros

                  • Acts Quickly
                  • No Side Effects
                  • Produces Results
                  • Simple To Take

                  Cons

                    Best Uses

                    • Daily Use
                    • Older People
                    • Women

                    Comments about Life Extension SAMe (S-adenosyl-methionine), 400 mg 50 enteric coated tablets:

                    I use this product daily with great results. My joints and mood are improved by this product. I trust this product, that I am using a pharmacudical grade supplement.

                    Comment on this review

                    (2 of 2 customers found this review helpful)

                     
                    5.0

                    Keeps joints moving

                    By Kimballjunction

                    from Mansfield, TX

                    About Me Medical Professional, Regular User

                    Pros

                    • Produces Results

                    Cons

                      Best Uses

                      • Daily Use
                      • Older People
                      • Women

                      Comments about Life Extension SAMe (S-adenosyl-methionine), 400 mg 50 enteric coated tablets:

                      Use to decrease joint discomfort. Takes abt 4 to 6 weeks to notice relief, and need to be consistent to see results

                      Comment on this review

                      (2 of 2 customers found this review helpful)

                       
                      5.0

                      SAMe- great experience

                      By SusanB

                      from Castro Valley, CA

                      About Me First Time User, Health Conscious

                      Pros

                      • Acts Quickly
                      • No Side Effects
                      • Produces Results
                      • Simple To Take

                      Cons

                      • Cost

                      Best Uses

                      • Daily Use

                      Comments about Life Extension SAMe (S-adenosyl-methionine), 400 mg 50 enteric coated tablets:

                      you have to experiment to find the right dose. I tried the 200 mg tabs first, and didn't get much relief from joint discomfort and stiffness until I went up to the 400 mg. I take two/day and really notice a different. Plus I like the idea that it provides such great liver/detoxification support.

                      Comment on this review

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