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Mitochondrial Energy Optimizer
120 capsules
Item Catalog Number: 01368 |
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The loss of cellular vitality is caused by a number of factors, including mitochondrial problems, glycation, and free radical reactions. Life Extension® members have access to a state-of-the art nutritional formula called Mitochondrial Energy Optimizer that helps protect delicate cellular structures and enables cells to perform life-sustaining metabolic processes.
Mitochondrial Energy Optimizer is designed to counteract age-related structural and functional changes by providing the following unique ingredients:
- Carnosine
As humans age, proteins in their bodies become irreversibly damaged by glycation reactions. Glycation is the cross-linking of proteins and sugar to form nonfunctioning structures (advanced glycation end-products or AGEs) in the body, which can lead to alterations of normal cell function. Carnosine is not only a powerful antiglycating agent, but it also protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.1-5
- Luteolin
Systemic inflammation is involved in most undesirable consequences of aging. Culprits behind chronic inflammatory reactions are pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor alpha. Luteolin is a super-potent plant extract that has been shown to modulate these dangerous inflammatory cytokines.6-11
- Benfotiamine
Effectively modulates multiple destructive biochemical pathways, including AGEs’ formation pathway, which are induced by higher than desirable blood glucose levels. Human mortality studies indicate that ideal fasting glucose levels are between 74–85 mg/dL. Yet many aging people have fasting glucose above 90 mg/dL, which is less than optimal.12-14 Benfotiamine protects endothelial cell integrity from the effects of high glucose levels. In addition, benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage.15
- Pyridoxal 5’-phosphate
Aging is associated with the formation of advanced glycation endproducts throughout the body. Pyridoxal 5’-phosphate is the active form of vitamin B6 that has been shown to protect against both lipid and protein glycation reactions.16-19
- R-lipoic acid
Destructive free-radical activity in the mitochondria plays a major role in the loss of cellular vitality. A new microencapsulated Bio-Enhanced® R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals. Two forms of lipoic acid are sold on the supplement market, but R-lipoic acid is far more potent.20-23
- Acetyl-L-carnitine arginate
The amino acid L-carnitine is required to transport fats into the mitochondria to be burned for cellular energy. Acetyl-L-carnitine arginate is a patented form of carnitine that also supports neurites in the brain.24
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References:
1. Hormones (Athens). 2008 Apr-Jun;7(2):123-32.
2. Protein Pept Lett. 2008;15(4):385-91.
3. J Alzheimer’s Dis. 2007 May;11(2):229-40.
4. Ann N Y Acad Sci. 2006 May;1067:369-74.
5. Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.
6. Life Sci. 2007 Nov 30;81(23-24):1602-14.
7. J Nutr. 2006 Jun;136(6):1517-21.
8. Biochem Pharmacol. 2005 Jan 15;69(2):241-8.
9. Immunology. 2005 Jul;115(3):375-87.
10. Am J Respir Crit Care Med. 2002 Mar 15;165(6):818-23.
11. Eur J Pharmacol. 2006 Jul 10;541(1-2):95-105.
12. Nat Med. 2003 Mar;9(3):294-9.
13. Acta Diabetol. 2001;38(3):135-8.
14. Diabetes. 2006 Aug;55(8):2231-7.
15. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7.
16. J Lipid Res. 2006 May;47(5):964-74.
17. Biochem Biophys Acta. 2001 Feb.14;1535(2):110-9.
18. J Am Soc Nephrol. 2005 Jan; 16(1):144-50.
19. Life Sci.1988;43(21):1725-31.
20. Biochem Biophys Res Commun. 1996 Apr 16;221(2):422-9.
21. FASEB J. 1999 Feb;13(2):411-8.
22. Antioxid Redox Signal. 2000 Fall;2(3):473-83.
23. Biochem Mol Biol Int. 1995 Oct;37(2):361-70.
24. Nerochem Res. 1995 Jan:20(1):1-9. |
| Supplement Facts |
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Serving Size 4 capsules |
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Servings Per Container 30 |
| Amount Per Serving |
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Vitamin B6 (as pyridoxal 5’-phosphate) |
100 mg |
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Sodium |
25 mg |
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Carnosine |
1000 mg |
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ArginoCarn® Acetyl-L-carnitine arginate dihydrochloride |
700 mg |
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Benfotiamine |
150 mg |
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R-Lipoic Acid (as microencapsulated Bio-Enhanced® stabilized Na-RALA sodium R-lipoate) |
150 mg |
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Luteolin (high purity luteolin as Pureolin™) |
8 mg |
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Other ingredients: gelatin, vegetable stearate, silica. |
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Contains soybeans.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives. |
Bio-Enhanced® is a registered trademark of Geronova Research, Inc.
ArginoCarn® is a registered trademark of Sigma-tau HealthScience, Inc. and is protected by U.S. patent nos. 6,703,042 B1 and 6,245,378 B1.
Pureolin™ is a trademark of Pharma Science Nutrients, Inc., and is used here under license. All rights reserved worldwide. |
| Dosage and Use |
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Take two capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner. |
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This product can be taken with or without food. | |
| Warnings |
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