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The requested item 00351 is obsolete and has been replaced. The new item is 01396.

St John's Wort Extract

300 mg 60 vegetarian capsules, Item# 01396


Retail price

$10.98 each

Save 25%

$8.24 each


Save 9%

$10.00 each

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$7.50 each

St. John’s Wort Extract Caps (0.3% Hypericin)
300 mg 60 vegetarian capsules
Item Catalog Number:

Although we’re only beginning to pull back the curtains that hide the inner workings of the human brain, we do know that several neurotransmitters (chemical messengers), including acetylcholine, GABA, norepinephrine, dopamine, and serotonin, help to regulate our moods and keep us happy.1-5 Why do brain levels of mood regulators fall in some people but not in others? We can’t fully answer that question although we know that genetics plays a major role.6-10 It may be that some of us are lucky enough to have large reserves of “happy” neurotransmitters in our brains, but others have just barely enough to keep a smile on their faces.

Although biochemistry is a big factor, we’re also affected by what happens to us in our lives. We’re all hit by unpleasant events that may cause brain levels of norepinephrine and dopamine to fall temporarily. People with naturally large reserves usually get through the troubling times with minimal difficulties, but those with initially low chemical levels are more likely to be affected.

St. John’s Wort (Hypericum perforatum extract) is a weak inhibitor of monoamine oxidase (MAO),80 which destroys monoamine neurotransmitters including dopamine in the brain and leads to low spirits. St. John’s Wort has also been shown to inhibit re-uptake of several neurotransmitters, such as serotonin, dopamine, noradrenaline, and GABA in the brain, and to reduce expression of interleukin-6.81-83 Each of these actions can contribute to alleviating low mood status by slowing the recycling of neurotransmitters needed for maintaining emotional balance. Flavonoids, hypericin and pseudo-hypericin, are the constituents thought to be associated with the benefits of St. John’s Wort. In particular, hypericin appears to be the active ingredient.84-86

References ​​
Supplement Facts

Serving Size 1 vegetarian capsule

Servings Per Container 60

Amount Per Serving

St. John's Wort (Hypericum perforatum) Extract (whole herb) [std. to 0.3% (0.9 mg) hypericin]

300 mg

Other ingredients: rice flour, vegetable cellulose (capsule), ascorbyl palmitate.


Dosage and Use
  • Take one capsule once or twice daily on an empty stomach, or as recommended by a healthcare practitioner.

Because St. John’s Wort may have numerous drug interactions (most commonly, MAOIs and SSRIs) consult your healthcare provider before taking this product if you are taking prescription medications. Avoid prolonged exposure to UV radiation (e.g. sunlight, tanning) when using this product.



by PowerReviews
Life ExtensionSt John's Wort Extract, 300 mg 60 vegetarian capsules

(based on 2 reviews)

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Ride boldly ride if youare seeking...

By Road Doctor

from Maryland's Eastern Shore

About Me Health Conscious, Medical Professional

See all my reviews


  • Good Value
  • No Side Effects


    Best Uses

    • Daily Use

    Comments about Life Extension St John's Wort Extract, 300 mg 60 vegetarian capsules:

    I have tried this product before with mixed results. There are no side-effects, It did not make anything worse, or much bettee after three weeks, even when combined with other compounds.

    Comment on this review

    (2 of 2 customers found this review helpful)


    Worth giving a try

    By Kadie

    from San Jose, CA

    About Me First Time User, Health Conscious

    See all my reviews


    • Effective
    • Good Value
    • No Side Effects


      Best Uses

      • Daily Use
      • Good Alternative

      Comments about Life Extension St John's Wort Extract, 300 mg 60 vegetarian capsules:

      Started using this product a few weeks ago it seems to be helping. Plan on continuing for a few months.

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