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Optimized Resveratrol with Synergistic Grape-Berry Actives

250 mg 60 vegetarian capsules, Item# 01430

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Optimized Resveratrol with Synergistic Grape-Berry Actives
250 mg 60 vegetarian capsules
Item Catalog Number: 01430

Life Extension has identified certain compounds that mimic calorie restriction’s ability to trigger youthful gene expression, the process by which genes transmit signals that slow certain aspects of aging. These compounds include trans-resveratrol (which researchers contend is the most active constituent), whole grape extract, quercetin, plus certain compounds found in berries, including trans-pterostilbene and now fisetin.

Findings from published scientific literature indicate that resveratrol may be the most effective compound for maintaining optimal health and promoting longevity.144 Resveratrol is a phytoalexin, a polyphenolic compound which is produced by Vitis vinifera as a response to attack by molds. Because of the widespread use of pesticides in modern wine making, including the practice of copper sulfation, the level of resveratrol in modern wines has plummeted. Red wine contains resveratrol, but the quantity varies depending on where the grapes are grown, the time of harvest and other factors. In fact, usually only one to three mg of resveratrol per liter of red wine is currently found, even in the most robust red wines. After years of relentless research, a standardized resveratrol extract is now available as a dietary supplement.

Research funded by the Life Extension Foundation showed that a combination of low-dose (20 mg) resveratrol plus grapeseed extract mimicked many of the favorable gene expression changes seen in calorie-restricted animals. Other studies, however, indicate that higher doses may be needed to obtain all of resveratrol’s positive benefits including promoting healthy insulin sensitivity, enhanced mitochondrial function, reduced expression of inflammatory factors, and protection against the effects of a high-fat diet.145-159

Life Extension has evaluated published studies on resveratrol to establish the doses humans might need to take to duplicate the remarkable laboratory findings. The results of Life Extension’s analysis yield a wide range of potentially effective doses: from 20 to 250 mg a day and higher. The resveratrol potency you choose may be based on your current state of health and/or your desire to reach the upper limits of a healthy human life span.

Pterostilbene, a stilbene compound from the same family as resveratrol, has been shown to work synergistically with resveratrol, to unlock one’s longevity genes … thus conferring even greater anti-aging benefits. In laboratory tests, pterostilbene has shown promise for supporting cardiovascular health, glucose levels that are already within normal range, anti-aging and cognitive function.178-185 It helps improve mitochondrial function and supports healthy metabolic function by activating SIRT1 and mimicking calorie restriction.186,187 It has also shown potential to ease inflammation and support antioxidant activity.181,185

Fisetin, found in strawberries, has the power to “switch on” cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function.160 Fisetin also supports aging neurons in the presence of oxidative stress.161-165 And, most importantly, it works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetin’s ability to stabilize resveratrol by shielding it from metabolic breakdown,166 thus extending its beneficial effects! So naturally we added it, along with these other four calorie restriction mimics, to this most advanced resveratrol formulation.

References ​​
Supplement Facts

Serving Size 1 vegetarian capsule

Servings Per Container 60

Amount Per Serving

Trans-Resveratrol [from Japanese knotweed (root) and whole red grape extracts] [also supplying glycosides (polydatin)]

250 mg

Red Grape (Full Spectrum French Red Wine Polyphenol Profile), Wild Blueberry, Japanese knotweed extract blend [supplying polyphenols, anthocyanins, OPCs, free resveratrol, resveratrol conjugates (epsilon-viniferin, trans and cis-polydatin), and resveratrol analogs (pterostilbene)]

85 mg

Quercetin (as quercetin dihydrate)

60 mg

Trans-Pterostilbene (from pTeroPure®)

0.5 mg

Fisetin [from (Rhus succedanea L.) extract (stem)]

10 mg

Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, silica, vegetable stearate, maltodextrin.

pTeroPure® is a registered trademark of ChromaDex, Inc.

Dosage and Use
  • Take one capsule daily with or without food, or as recommended by a healthcare practitioner.
Caution

If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.

Warnings

REVIEW SNAPSHOT®

by PowerReviews
Life ExtensionOptimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg 60 vegetarian capsules
 
4.8

(based on 64 reviews)

Ratings Distribution

  • 5 Stars

     

    (52)

  • 4 Stars

     

    (9)

  • 3 Stars

     

    (2)

  • 2 Stars

     

    (1)

  • 1 Stars

     

    (0)

98%

of respondents would recommend this to a friend.

Pros

  • Simple to take (53)
  • No side effects (43)
  • Produces results (41)
  • Acts quickly (17)
  • Good taste (10)

Cons

  • No results (5)

Best Uses

  • Daily use (59)
  • Older people (33)
  • Women (32)
  • Men (30)
  • Short-term solution (5)
    • Reviewer Profile:
    • Regular user (47), Health conscious (46), First time user (7), Medical professional (7)

Most Liked Positive Review

 

Very Good Mood Stabilizer

The resveratrol is a great mood enhancer, and escape from the stresses of your everyday issues. It gives you a long lasting "buzz," throughout the day. The one down side...Read complete review

The resveratrol is a great mood enhancer, and escape from the stresses of your everyday issues. It gives you a long lasting "buzz," throughout the day. The one down side I noticed, was that after about six to eight weeks or so, it starts to lose its effects as your body gets used to it.

VS

Most Liked Negative Review

 

Not Sure

I don't enjoy red wine so I take this to get the antioxidant and heart health benefits. Not sure if it's helping but antioxidants can't hurt.

I don't enjoy red wine so I take this to get the antioxidant and heart health benefits. Not sure if it's helping but antioxidants can't hurt.

Reviewed by 64 customers

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Displaying reviews 1-10

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(0 of 1 customers found this review helpful)

 
4.0

Wow!

By Erik the Survivor

from Ellicottville, NY

About Me Health Conscious, Regular User

See all my reviews

Pros

  • Acts Quickly
  • Produces Results
  • Simple To Take

Cons

  • Questionable Fillers

Best Uses

    Comments about Life Extension Optimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg 60 vegetarian capsules:

    Great formula and product. I definitely immediately noticed results. My one issue is that life extension uses fillers, because I do not believe an ingredient can ever be "inactive".

    Comment on this review

    (1 of 2 customers found this review helpful)

     
    5.0

    It works for me!

    By Lynne the snowshoer

    from Amsterdam, NY

    About Me Health Conscious

    Pros

    • Acts Quickly
    • No Side Effects
    • Produces Results
    • Simple To Take

    Cons

      Best Uses

      • Older People
      • Short-Term Solution
      • Women

      Comments about Life Extension Optimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg 60 vegetarian capsules:

      I shed 75 lbs through walk, weights & diet. But, last November I started using "Opt. Resveratrol" daily & was able to maintain current weight throughout all my holiday eating. Since the new year I have shed an additional 4 lbs and am at my desired weight. Now I'll go from daily use to as-needed.

      Comment on this review

      (0 of 1 customers found this review helpful)

       
      5.0

      RESVERATROL

      By JACOB WERBA

      from MIRAMAR FLORIDA

      About Me Regular User

      See all my reviews

      Pros

      • Acts Quickly
      • Good Taste
      • No Side Effects
      • Produces Results
      • Simple To Take

      Cons

      • Results Lessen Over Time

      Best Uses

      • Daily Use
      • Men
      • Older People
      • Short-Term Solution

      Comments about Life Extension Optimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg 60 vegetarian capsules:

      EVERY MORNING 2 PILLS WITH NO FOOD

      YES THEY ARE GREAT

      Comment on this review

      (1 of 2 customers found this review helpful)

       
      5.0

      Benefits without the booze.

      By Cheryl K.

      from New Orleans

      About Me Health Conscious, Regular User, Senior

      Pros

      • No Side Effects
      • Produces Results
      • Simple To Take

      Cons

        Best Uses

        • Daily Use
        • Women

        Comments about Life Extension Optimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg 60 vegetarian capsules:

        Besides the fact, that the service is impeccable; I can always rely on a quality product that has the most current formula available. Thank you for your consistency!

        Comment on this review

        (1 of 1 customers found this review helpful)

         
        5.0

        Excellent Product

        By Carl S.

        from Detroit Metro

        See all my reviews

        Pros

        • Produces Results
        • Simple To Take

        Cons

          Best Uses

            Comments about Life Extension Optimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg 60 vegetarian capsules:

            I like this product because it also contains Quercetin, which is very helpful to general health

            Comment on this review

            (0 of 1 customers found this review helpful)

             
            5.0

            This is a great product

            By Jackie

            from Reno, nv

            About Me Health Conscious, Regular User

            See all my reviews

            Pros

            • No Side Effects
            • Produces Results
            • Simple To Take

            Cons

              Best Uses

              • Daily Use
              • Men
              • Older People
              • Women

              Comments about Life Extension Optimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg 60 vegetarian capsules:

              This is a good product and a must in my diet.

              Comment on this review

              (2 of 2 customers found this review helpful)

               
              5.0

              wouldn't be without

              By sunshine

              from Los Angeles

              About Me Regular User

              See all my reviews

              Pros

              • No Side Effects
              • Produces Results
              • Simple To Take

              Cons

              • NO NEGATIVES

              Best Uses

              • Daily Use
              • Men
              • Older People
              • Women

              Comments about Life Extension Optimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg 60 vegetarian capsules:

              I love everything about this supplement. It has all the supporting ingredients to optimize its effectiveness. Love it!

              Comment on this review

               
              5.0

              Resveratrol Order

              By diva

              from Denver CO

              About Me Health Conscious, Regular User

              Pros

              • No Side Effects
              • Simple To Take

              Cons

                Best Uses

                • Daily Use
                • Older People
                • Women

                Comments about Life Extension Optimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg 60 vegetarian capsules:

                I use this product daily.

                Comment on this review

                (1 of 3 customers found this review helpful)

                 
                2.0

                Not much change

                By Richard Ridler

                from Mount Dora , FL

                About Me Married 58 Yo Male Ex-me, Medical Professional

                Pros

                • No Side Effects
                • Simple To Take

                Cons

                • No Effect Seen While Taki
                • No Results

                Best Uses

                • Daily Use

                Comments about Life Extension Optimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg 60 vegetarian capsules:

                Did not see where this did anything good or bad.

                Comment on this review

                 
                4.0

                true product

                By lmbr

                from miami, FL

                About Me Health Conscious, Regular User

                Pros

                • No Side Effects
                • Simple To Take

                Cons

                  Best Uses

                  • Daily Use

                  Comments about Life Extension Optimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg 60 vegetarian capsules:

                  I take it every morning. I trust this product. Many other brands claim to have pure resveratrol but when you read the nutritional facts it really doesn't have much at all.

                  Comment on this review

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