Life Extension has long warned about the dangers of high homocysteine and has advised taking vitamin B6, folic acid, and vitamin B12 to help maintain healthy arteries.
Many doctors and blood laboratories consider homocysteine levels of 5–15 micromoles per liter (µmol/L) of blood to be “normal.” However, recent reports indicate that maintaining a homocysteine level lower than the 12 µmol/L can help maintain cardiac health.137,138 Because there is no “safe” level of homocysteine, Life Extension recommends keeping levels even lower, preferably below 8 µmol/L.
Studies have shown that folic acid and vitamins B6 and B12 promote healthy homocysteine levels and support endothelial function. In a randomized, double-blind, placebo-controlled trial in elderly people, folic acid combined with vitamin B12 supplementation significantly reduced plasma homocysteine concentration by 36%.139
For those seeking to lower their homocysteine, Homocysteine Resist provides a potent dose of 250 mg of vitamin B6 along with 400 micrograms of 5-methyltetrahydrofolate (the biologically active form of folic acid) and 500 micrograms of vitamin B12.