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Optimized Folate (L-Methylfolate)

1000 mcg 100 vegetarian capsules, Item# 01439

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Optimized Folate (L-Methylfolate)
1000 mcg 100 vegetarian capsules
Item Catalog Number: 01439

Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.

Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called  5-methyltetrahydrofolate (5-MTHF).190 Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine).

A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate concentration, an indicator of folate status191 compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency192 since it requires no conversion to become metabolically active.

People with elevated homocysteine levels have a greater risk of cognitive decline.194 Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain — the neurotransmitter associated with memory.

Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12),195 vitamin B6, and riboflavin.196,197

References
Supplement Facts

Serving Size 1 vegetarian capsule

Servings Per Container 100

Amount Per Serving

Folate [as (6S)-5-Methyltetrahydrofolic acid, glucosamine salt]^

1000 mcg

Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate.

^Quatrefolic® is a registered trademark of Gnosis S.p.A.

Dosage and Use
  • Take one capsule daily with food, or as recommended by a healthcare practitioner.
Warnings

REVIEW SNAPSHOT®

by PowerReviews
Life ExtensionOptimized Folate (L-Methylfolate), 1000 mcg 100 vegetarian capsules
 
4.8

(based on 9 reviews)

Ratings Distribution

  • 5 Stars

     

    (7)

  • 4 Stars

     

    (2)

  • 3 Stars

     

    (0)

  • 2 Stars

     

    (0)

  • 1 Stars

     

    (0)

100%

of respondents would recommend this to a friend.

Pros

  • Easy to swallow (7)
  • Effective (7)
  • Simple to take (7)
  • Easy on stomach (5)

Cons

    Best Uses

    • Daily use (8)
    • Men (3)
      • Reviewer Profile:
      • Health conscious (8)

    Reviewed by 9 customers

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    Displaying reviews 1-9

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    4.0

    good stuff

    By jerry

    from bedford hills

    About Me Health Conscious

    See all my reviews

    Verified Buyer

    Pros

    • Easy on Stomach
    • Easy To Swallow
    • Simple To Take

    Cons

      Best Uses

      • Daily Use
      • Men
      • Older People

      Comments about Life Extension Optimized Folate (L-Methylfolate), 1000 mcg 100 vegetarian capsules:

      I've used it for 15 years and it works to keep me energetic.

      Comment on this review

       
      5.0

      GREAT PRODUCT

      By PAUL

      from FL

      About Me First Time User, Medical Professional

      See all my reviews

      Pros

      • Easy on Stomach
      • Easy To Swallow
      • Effective
      • Simple To Take

      Cons

        Best Uses

        • Daily Use
        • Men

        Comments about Life Extension Optimized Folate (L-Methylfolate), 1000 mcg 100 vegetarian capsules:

        IT IS HELPING ME GET MY ENERGY LEVEL UP!

        Comment on this review

        (1 of 1 customers found this review helpful)

         
        5.0

        Great Folic Acid Supplement

        By HappyGoHealthy

        from New Jersey

        About Me Health Conscious

        Pros

        • Simple To Take

        Cons

          Best Uses

          • Daily Use

          Comments about Life Extension Optimized Folate (L-Methylfolate), 1000 mcg 100 vegetarian capsules:

          Folic acid is needed for cardiovascular health...but, it's only effective if the body can use it! This supplement has the edge because of it's bioavailablity. We have been using it for years. Great product. Great price.

          Comment on this review

           
          5.0

          Easy to take

          By the lady at the store

          from Paradise, Ca

          About Me First Time User, Health Conscious

          See all my reviews

          Pros

          • Easy on Stomach
          • Easy To Swallow
          • Effective
          • Simple To Take

          Cons

            Best Uses

              Comments about Life Extension Optimized Folate (L-Methylfolate), 1000 mcg 100 vegetarian capsules:

              I use daily, it is small and easy to swallow.

              Comment on this review

              (7 of 7 customers found this review helpful)

               
              5.0

              LEF ahead of the curve again with folate

              By PDX fan

              from Portland, Oregon

              About Me Health Conscious

              Pros

              • Easy To Swallow
              • Effective

              Cons

                Best Uses

                • Daily Use

                Comments about Life Extension Optimized Folate (L-Methylfolate), 1000 mcg 100 vegetarian capsules:

                LEF is ahead of the curve again with its methyl-folate. A far safer and more effective product than all the synthetic folic acids on the market. And a very important product for those who don't convert folate efficiently. It has helped our son with cognitive focus and in raising low levels of adrenaline into the optimal zone despite a very high-pressure job (the body needs methyl molecules to make adrenaline).

                Bravo to LEF for changing the folic acid in its 2-perday multiple to methyl folate. I wish LEF would now use only converted forms of the other types of vitamin B in its multiple, and create a super B complex with the same.

                Comment on this review

                (1 of 1 customers found this review helpful)

                 
                5.0

                Love this Folate

                By Geo. the conscious man

                from San Antonio Texas

                About Me Health Conscious

                See all my reviews

                Pros

                • Easy on Stomach
                • Easy To Swallow
                • Effective
                • Simple To Take

                Cons

                  Best Uses

                  • Daily Use
                  • Women

                  Comments about Life Extension Optimized Folate (L-Methylfolate), 1000 mcg 100 vegetarian capsules:

                  I love this product which I take every day.
                  it is a small cap and easy to swallow.

                  Comment on this review

                  (6 of 6 customers found this review helpful)

                   
                  5.0

                  This is my regular supplement

                  By Olja

                  from Detroit, MI

                  About Me Health Conscious

                  Pros

                  • Effective

                  Cons

                    Best Uses

                    • Daily Use

                    Comments about Life Extension Optimized Folate (L-Methylfolate), 1000 mcg 100 vegetarian capsules:

                    I've been using it in combination with SAM-e and B12 (in form of methyilcobalamin) and it helped very much with my estrogen metabolizam. It increased my estriol level (good estrogen) and helped my body to make more 2-methoxyestradiol which is very protective for women! My blood test showed much better results!

                    Comment on this review

                     
                    4.0

                    easy to swallow

                    By G

                    from Michigan

                    About Me Health Conscious

                    Pros

                    • Easy To Swallow
                    • Effective
                    • Simple To Take

                    Cons

                      Best Uses

                      • Daily Use

                      Comments about Life Extension Optimized Folate (L-Methylfolate), 1000 mcg 100 vegetarian capsules:

                      I started taking it "doctors orders" along with fish oil, about 2 years ago to help with my mental health . My issues have subsided so I feel the product is effective.

                      Comment on this review

                      (1 of 3 customers found this review helpful)

                       
                      5.0

                      THIS PRODUCT GOES WITH OTHERS!

                      By DEANN

                      from GILLETTE, WYOMING

                      About Me Health Conscious

                      Pros

                      • Easy on Stomach
                      • Easy To Swallow
                      • Effective
                      • Simple To Take

                      Cons

                        Best Uses

                        • Daily Use
                        • Men
                        • Women

                        Comments about Life Extension Optimized Folate (L-Methylfolate), 1000 mcg 100 vegetarian capsules:

                        THIS PRODUCT GOES WITH TWO OTHER VITAMINS TO MAKE UP A BRAND NAME PRODUCT. (IT IS FOR NEUROPATHIES)I WOULD LIKE TO PURCHASE ALL OF THE VITAMINS THAT I TAKE FROM LIFE EXTENSIONS. I PLAN TO CALL SOON TO SEE IF I CAN DO THIS. THANK YOU.

                        Comment on this review

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