The Optimized African Mango Irvingia with Phase 3™ Calorie Control Complex formulation provides a combination of natural compounds that combat age-related fat accumulation via the following eight distinct mechanisms:
- Delaying digestion and absorption of sucrose.
- Enhancing resting energy expenditure at the cellular level.
- Slowing the absorption of dietary fat from the intestines.
- Moderating alpha-amylase enzyme activity to reduce the absorption of carbohydrates into the bloodstream.
- Reducing alpha-glucosidase enzyme activity to further slow the absorption of starches and sugars into the bloodstream.
- Supporting leptin sensitivity to stimulate lipolysis.
- Supporting youthful levels of adiponectin to help maintain healthy insulin sensitivity.
- Moderating glycerol-3-phosphate dehydrogenase enzyme activity to reduce the amount of ingested starches that are converted to triglycerides and stored as fat.
Phase 3™ Sucrase Modulator
While Life Extension customers understand the benefits of calorie restriction, that doesn’t make it any easier to cut back on refined sugar, one of the major calorie culprits in the American diet.
Sucrase is the name given to a number of enzymes that catalyze the hydrolysis of sucrose to fructose and glucose in the small intestine for absorption into the bloodstream. Phase 3™ is a patented compound that functions as a beneficial sucrase modulator. It contains L-Arabinose, a natural substance found in plants that reduces the number of absorbed calories from sugar.43 Phase 3™ can help support healthy insulin metabolism and blood sugar levels in those already within normal range. Phase 3™ is just one ingredient in Optimized Irvingia.
Green Tea Phytosome Cellular Energy Enhancer
The ability of green tea extracts to inhibit the breakdown and absorption of dietary fat has been the subject of research studies across the globe. Mounting scientific research has documented the metabolic effects of green tea polyphenols. A proprietary phytosome complex has shown an ability to increase the absorption of green tea polyphenols into the bloodstream better than conventional tea extracts, resulting in peak plasma levels of the critical green tea polyphenol epigallocatechin-3-gallate.44,45
Participants in a human clinical trial showed an average weight loss of 30 pounds and a 10% reduction in waist circumference in 90 days when 300 mg/day of this new green tea phytosome was taken in conjunction with a reduced-calorie diet.46 The placebo group that followed the same reduced-calorie diet lost only 9.9 pounds on average and only 5% of their waist size. Optimized Irvingia contains the exact same green tea phytosome as was used in this study.
The Alpha-Amylase Enzyme
Aging reduces our ability to utilize the carbohydrates (and fats) that constitute what most would consider part of a healthy diet. The result is that as we grow older, our bloodstreams become bloated with glucose and triglycerides in direct contrast to the metabolic profile we have in our younger years. Emerging scientific research suggests that the alpha-amylase enzyme plays an undesirable role in the digestion of dietary carbohydrates and subsequent absorption of calories from starch and sugar.
A natural bean extract (Phaseolus vulgaris) moderates alpha-amylase activity. In a human trial in which all overweight participants were placed on a 2,000–2,200-calorie, carbohydrate-rich diet, those taking Phaseolus vulgaris lost 6.5 pounds and 1.2 inches in waist size in only 30 days compared with 0.8 pounds and 0.2 inches in the placebo group.47 Optimized Irvingia contains the identical Phaseolus vulgaris used in this study.
The Alpha-Glucosidase Enzyme
Another intestinal enzyme that enables carbohydrate absorption is alpha-glucosidase. A patented seaweed extract (InSea2®) has demonstrated the ability to help maintain healthy levels of both alpha-glucosidase and alpha-amylase.50 When given to laboratory animals, this seaweed extract reduced after-meal (postprandial) glucose elevations by up to 90% compared with non-supplemented animals.51
Remember, young healthy individuals rapidly convert ingested fats and sugars into energy. Age-related changes decrease our metabolic capacity to efficiently utilize dietary fats and sugars. It is thus paramount for aging people to reduce their absorption of excess calories. By taking nutrients before each meal that reduce the activity of carbohydrate and fat digesting enzymes, the calorie burden is significantly reduced. Optimized Irvingia provides the same InSea2® extract used in laboratory studies.
Fat cells (adipocytes) secrete a hormone called leptin that tells our brain we have eaten enough.52 Leptin can also facilitate the breakdown of stored triglycerides in our adipocytes via the process of lipolysis. Heavy individuals have startlingly high blood levels of leptin, indicating that their cells have become resistant to the leptin that is supposed to prevent them from putting on so many fat pounds.
An extract from an African mango called Irvingia gabonensis has been shown to help support leptin sensitivity in overweight people. In a recently published study, irvingia demonstrated beneficial effects upon leptin blood levels, followed by weight loss and inches off the waistline.48,53 In addition to supporting healthy leptin sensitivity, irvingia has demonstrated the following beneficial effects on key aspects of metabolism:
- Glycerol-3-phosphate dehydrogenase is an enzyme involved in the complex biochemical process that converts ingested starch and sugar calories to stored body fat. Irvingia has been shown in studies involving fat cells to reduce the activity of glycerol-3-phosphate dehydrogenase,48,54 which may help reduce the impact of starch and sugar calories on body fat.
- Scientific research on fat cells suggests that irvingia has alpha-amylase-inhibiting properties55 (like InSea2® and Phaseolus vulgaris) which can help support a slowing of the rate of carbohydrate absorption from the intestines and a reduction of the caloric impact of starchy and sugary foods.54
- Adiponectin is a hormone involved in helping to maintain insulin sensitivity on the membranes of energy-producing cells. Big fat cells produce less adiponectin, and overweight people need to be especially concerned about maintaining healthy levels of adiponectin to support insulin sensitivity and metabolic fitness. Scientific data suggests that irvingia helps support healthy adiponectin levels.53
Optimized Irvingia with Phase 3™ Calorie Control Complex is indeed an innovative multi-modal approach to weight loss with an additional benefit. By helping to slow the absorption of starchy food or sugars, it reduces their caloric impact. And according to a recent mammalian study, those following a calorie-restricted diet were shown to significantly reduce the risk of mortality from age-related causes.56 This suggests that regular supplementation with this or any irvingia formulation may help provide anti-aging benefits similar to those found in this recent study.
Summary of Human Studies With Optimized Irvingia Ingredients
||Treatment vs. Placebo
Green Tea Phytosome Extract46
|100 overweight subjects placed on a hypocaloric diet (men: 1,850 calories; women: 1,350 calories) randomized to receive 300mg/day of green tea phytosome extract or placebo for 90 days46
Average weight loss
30.1 pounds vs. 9.9 pounds
Waist size reduction
10% vs. 5%
(14% vs 7% in men)
|60 overweight subjects placed on a 2,000-2,200 calorie, carbohydrate-rich diet and randomized to either 445 mg/day of white kidney bean extract or placebo for 30 days47
Average weight loss
6.5 pounds vs. 0.8 pounds
Waist size reduction
1.2 inches vs. 0.2 inches
Integra-Lean® African Mango Irvingia gabonensis Extract48
|102 overweight subjects randomized to 150 mg of Irvingia twice daily or placebo for 10 weeks48
Average weight loss
28 pounds vs. 1.5 pounds
Waist size reduction
6.4 inches vs. 2.1 inches
|50 non-diabetic subjects were used to study the suppression effects of L-Arabinose and chromium on capillary glucose49
Consuming LA-Cr simultaneously with a 70 gram sucrose challenge suppressed the glucose response an average of -20% compared to the control group over four different time periods
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
Due to license restrictions this product cannot be sold in Korea or France.