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Excess levels of the enzyme 5-lipoxygenase or 5-LOX sets in motion inflammatory responses that has been linked to common degenerative effects in aging individuals.1-5 Normal aging results in higher-than-desired levels of 5-LOX.
The typical American diet adds to the danger. Foods rich in omega-6 fatty acids like red meat, poultry, eggs and dairy products, along with high-glycemic carbohydrates, trigger overproduction of arachidonic acid. In response to high levels of arachidonic acid, the body produces the 5-LOX enzyme.
5-LOX breaks down arachidonic acid to pro-inflammatory compounds like leukotriene B4,6 a molecule that attacks joints, arterial walls, and other tissues. 5-LOX itself facilitates undesirable cell division changes.
The good news is that extract of the Indian plant Boswellia serrata has been shown to neutralize 5-LOX. Used for centuries to help with inflammatory issues, boswellia acts as a natural 5-LOX inhibitor, intervening at the cellular level to block its unwanted effects. Confirmatory data reveal that a compound contained in boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid)7,8 is the key to its beneficial action. The problem is that boswellia is not readily absorbed into the blood.9
For this reason, a patent-pending, standardized form of boswellia called AprèsFlex™ is being introduced that absorbs into the blood 52% more than previously available boswellia extracts.9 Each 100 mg vegetarian capsule of 5-LOX Inhibitor with AprèsFlex™ is standardized to provide 20% of active AKBA from boswellia. Most people need only one capsule a day. |