St. John’s Wort (Hypericum perforatum extract) is a weak inhibitor of monoamine oxidase (MAO),64 which destroys monoamine neurotransmitters including dopamine in the brain and leads to low spirits. St. John’s Wort has also been shown to inhibit re-uptake of several neurotransmitters, such as serotonin, dopamine, noradrenaline, and GABA in the brain, and to reduce expression of interleukin-6.65-67 Each of these actions can contribute to alleviating low mood status by slowing the recycling of neurotransmitters needed for maintaining emotional balance. Flavonoids, hypericin and pseudo-hypericin, are the constituents thought to be associated with the benefits of St. John’s Wort. In particular, hypericin appears to be the active ingredient.68-70
This botanical from Planetary Formulas® supports mental well-being.