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Life Extension® Weight Loss Guide

by Steven V. Joyal, MD and William Faloon
3rd edition hardcover, 154 pp.

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As we age, our bodies are programmed to accumulate excess body fat. There is no single cause. On the contrary, multiple obesity factors predispose us to this age-induced weight gain. The encouraging news is that proven methods exist to correct these obesity inducers. You will not find them, however, in a single pill.

For example, drugs that block dietary fat absorption are approved by the FDA to facilitate weight loss. Using this fat blocking method alone will not meet the expectations of most overweight individuals. One reason is that excess carbohydrate absorption will lead to the same fat accumulation as does overconsumption of dietary fats. On the flip side, drugs or nutrients that block the rate of carbohydrate absorption may not induce profound weight loss if too many dietary fats wind up in the bloodstream.

People fail to accept that as they grow older, they lack the metabolic capacity to efficiently convert ingested calories into energy. These metabolic deficits are increasingly being referred to as postprandial disorders. The term postprandial means after-meal and the disorders they refer to are too many fats and sugars remaining in the bloodstream long after meals are eaten. Overweight individuals today suffer chronically with high blood levels of fat remnants and glucose that may frustrate the best formulated weight-loss program.

One might think that by merely eating less, blood fat (triglycerides) and sugar (glucose) levels will drop low enough to prompt weight reduction. The sad fact is that many overweight individuals are so severely compromised on a metabolic and hormonal basis that sustained fat loss cannot be achieved unless corrective actions are first taken. An imbalance of leptin, insulin, thyroid, and/or sex steroid hormones, for example, may inhibit the desired release of stored body fat, even in response to calorie restriction.

As we age, there is a progressive and extensive decline in resting energy expenditure. This reduction in basal metabolic rate is another reason that people accumulate more body fat even though they may be eating less than they used to. In fact, your body's basal metabolic rate decreases by about 2% per decade after age 40. For a man aged 40 years who weighs 156 pounds, this means that during the year following his 50th birthday, he is predisposed to gain an extra 3.5 pounds of body fat from the age-related reduction in metabolic rate alone!1

Metabolic enhancers by themselves, however, are not enough to compensate for the other obesity inducers plaguing aging adults.

Nine Pillars of Successful Weight Loss

When it comes to weight loss, mainstream medicine has recommended "diet and exercise" for so long that this phrase has become more of a cliché than any kind of momentous discovery. The science you will read about next reveals why aging people need to do a lot more than reduce calorie intake and increase physical activity if they are going to lose and keep off excess body fat.

The Life Extension® Weight Loss Guide is the first book to uncover all age-related obesity factors and provide practical solutions to correct them. The following Nine Pillars to Successful Weight Loss comprises a portion of the comprehensive program revealed in the Life Extension® Weight Loss Guide:

Pillar Number 1: Restore Insulin Sensitivity

Aging causes our muscle cells to become resistant to insulin. The result is that insulin is less efficient at helping the cells in our muscles and liver to store glucose, with the result being chronically elevated blood glucose levels that convert to body fat. The Life Extension® Weight Loss Guide outlines an all-inclusive program to reestablish youthful insulin sensitivity.

Pillar Number 2: Restore Adipocyte Signaling

Adipocytes are fat cells, and the adipocyte is the primary site for fat storage. Adipocytes of obese individuals are bloated with triglycerides—the form that most fat exists in the body. Fat storage and release is tightly regulated by adipocyte command signals. The Life Extension® Weight Loss Guide will teach you how to harness adipose command signals (such as leptin, adiponectin and glycerol-3-phosphate dehydrogenase) that are crucial for aging individuals to achieve youthful cell signaling so critical for fat metabolism.

Pillar Number 3: Achieve Youthful Hormone Balance

The high failure rate of dieting is partially attributable to the alteration in hormone levels that occurs as part of normal aging. For instance, a large percentage of men today suffer from abdominal obesity—the most dangerous kind of body fat. It is often difficult, if not impossible, for aging men to lose inches off their waistline if they are deficient in free testosterone. Women likewise suffer hormone imbalances that preclude fat reduction. The Life Extension® Weight Loss Guide provides a complete program to help restore all hormones involved in metabolism and body fat deposition to youthful ranges.

Pillar Number 4: Control Rate of Carbohydrate Absorption

When excessive amounts of dietary carbohydrates are absorbed into the bloodstream, a surge in blood glucose results. Too much glucose causes excessive increases in insulin. This surplus insulin is associated with rebound hunger as blood glucose levels fall too low in response to insulin overload. Excess insulin also interferes with the release of body fat stores. The Life Extension® Weight Loss Guide recommends specific nutrients and approved medications that when taken before meals dramatically reduce the surge of glucose into the bloodstream from excess amounts of dietary carbohydrate.

Pillar Number 5: Balance Brain Serotonin Levels

When the brain has balanced levels of the hormone serotonin, satiety normally occurs. A serotonin deficiency has been associated with the carbohydrate binging that contributes to the accumulation of excess body fat. The Life Extension® Weight Loss Guide provides natural methods to balance brain serotonin as well as other satiety enhancing factors in the brain.

Pillar Number 6: Restore Resting Expenditure Rate

It is often challenging for aging humans to lose significant body fat storage even when following a low-calorie diet. Long term weight loss requires increasing resting energy expenditure, and the Life Extension® Weight Loss Guide outlines non-stimulating methods to safely accomplish this.

Pillar Number 7: Inhibiting Lipase and Binding Bile Acids

Dietary fats are broken down for absorption into your bloodstream by the bile acids released by the liver into the small intestine and the enzyme lipase. Inhibiting lipase and binding bile acids results in fewer fat calories being absorbed and thus reduces the amount of fat stored in your adipocytes (fat cells). The Life Extension® Weight Loss Guide reveals nutrients and drugs that inhibit lipase and bind to bile in order to reduce the amount of fat absorbed from ingested calories.

Pillar Number 8: Increase Physical Activity

In addition to using up stored fat calories, exercise induces beneficial changes at the cellular level that contribute to weight control. It improves insulin sensitivity and mimics the effects of certain antidiabetic drugs which can have a favorable impact on fat distribution.

Pillar Number 9: Eat to Live a Long and Healthy Life

Aging individuals have the choice of ingesting foods that are known to promote weight gain (and cause horrendous diseases) or selecting healthier foods that facilitate weight loss. The Life Extension® Weight Loss Guide reveals little known scientific facts that can easily enable you to alter your diet. For instance, the ingestion of foods cooked at high temperatures (over 250 degrees Fahrenheit) accelerates the aging process while foods cooked at lower temperatures have been shown to facilitate weight loss. So just changing how your foods are prepared could help you shed body fat and, at the same time, protect against age-related disease.

The Life Extension® Weight Loss Guide is published by an organization with an unparalleled 30-year track record of preventing and treating the diseases of aging. If you're tired of seeing ads for products that claim miraculous weight loss but don't deliver, the Life Extension® Weight Loss Guide will open your eyes to scientific weight loss strategies that no one else has tied together.