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Galectin-3 with Propeptide of Brain Natriuretic Peptide (NT-proBNP)

Item# LC142005

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Galectin-3 with Propeptide of Brain Natriuretic Peptide (NT-proBNP)

Item Catalog Number: LC142005

Galectin-3 is a protein which has recently been identified as a mediator of heart failure development and progression.1 It is used in conjunction with clinical evaluation as an aid in assessing the prognosis of people with chronic heart failure. Galectin-3 levels > 17.8 ng/mL are associated with a more progressive form of heart failure.2

NT-proBNP is the N-terminal fragment of brain natriuretic peptide. Although levels of BNP and NT-proBNP are similar in normal individuals, NT-proBNP levels are substantially greater than BNP levels in people with cardiac disease due to increased stability (half-life) of NT-proBNP in circulation.

Since Natriuretic Peptides and Galectin-3 measurements reflect separate and distinct biological processes measuring them together may aid in identifying a subgroup of people with heart failure who have a considerably higher risk of mortality.3

This panel does not require fasting. Take all medications as prescribed.

Galectin-3 can also be measured with B-Type Natriuretic Peptide. See test code LC140080.

References
1. Christenson R, Duh SH, Wu AB, et al. Multi-center determination of galectin-3 assay performance characteristics: Anatomy of a novel assay for use in heart failure. Clin Biochem. 2010 May; 43(7-8):683-690.
2. BG Medicine BGM Galectin - 3™ (Galectin-3 Assay) Product Insert. Waltham, Mass BG: BG Medicine Ind; November 2010.
3. van Kimmenade RR, Januzzi JL, Ellinor PT, et al. Utility of amino-terminal pro-brain natriuretic peptie, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol. 2006 Sep 19; 48(6): 1217-1224.