- PT/PTT with INR
D-dimer is a test that measures the tendency of blood to clot inappropriately. The higher the number, the greater the risk for conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE) and arterial plaque rupture.
Life Extension® believes if you are prone to clotting, you are at greater risk for heart disease and stroke. D-dimer may be ordered when you have symptoms of DVT, such as leg pain, tenderness, swelling, discoloration, edema … or symptoms of PE, such as labored breathing, coughing, and lung-related chest pain.
A sub analysis of RE-LY trial data presented at a 2010 conference of the American Heart Association indicates that D-dimer level at baseline appears to be an independent predictor of risk for cardiovascular events including stroke. A baseline D-dimer concentration of less than 298 µg/L was associated with a 1.4% rate of stroke or systemic embolism while baseline D-dimer of 823 µg/L or more was associated with a nearly threefold increase in risk, according to John Eikelboom, MBBS, MSc, of the Population Health Research Institute in Hamilton, Ontario (Eikelboom, J et al. American Heart Association 2010; Abstract 18321)
Doctors also like to check coagulation profiles which include PT and PTT. PT stands for Prothrombin Time and PTT stands for Partial Thromboplastin Time. They are measurements of how quickly a blood clot forms. These tests may be ordered when people present with unexplained bleeding or bruising or with chronic conditions such as liver disease or lupus.
Fibrinogen, a protein produced by the liver, plays a role in the development of arterial plaque and can also cause acute blood clots. The formation of acute blood clots can initiate a heart attack or stroke.
This test also contains an INR (International Normalized Ratio) for those people taking Coumadin. Doctors use an INR to assess the effect of the drug.
Fasting is not required. Take all medications as prescribed.