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Recommendation #7:
Preserve Brain Function

Bioavailable to the Brain

Nutritional support for the brain is challenging as a barrier called the blood-brain barrier keeps out toxins as well as beneficial nutrients and drugs. Cognitex® contains a grape seed extract called Leucoselect® Phytosome™. By pairing procyanidins from grape seed extract with phosphatides from soy lecithin (as is done with Leucoselect ® Phytosome™), the uptake and distribution to target tissues of the grape seed polyphenols is enhanced.

Once in the brain, the grape seed polyphenols trap dangerous hydroxyl free radicals that turn fat rancid. These fats make up the outer lipid membrane of trillions of brain cells. Leucoselect® Phytosomepolyphenols improve age-related cognitive decline, and reduce age-related oxidative damage and cerebral amyloid deposition. Preclinical studies also suggest that these polyphenols could improve blood circulation in the brain.12-14

Molecular Size Matters

High levels of procyanidins from grape seed extract do not ensure an extract is going to have a beneficial effect on the brain. Polyphenols with higher molecular weight cannot be absorbed. Leucoselect® Phytosome™ contains small molecular size polyphenols called procyanidins for advanced neurological activity.

A Difference You Can Feel

Taking dietary supplements can be an act of faith as we often cannot feel what they are doing. Cognitex® provides the patented, non-stimulating agent called Sensoril®, a proprietary standardized extract of ashwagandha. This herb is used in Ayurvedic traditional medicine for boosting brain function and alleviating mental fatigue. Advanced extraction practices allow for a highly concentrated yet balanced brain nutrient. The effects can often be felt immediately with greater alertness and focus, but without jitteriness.

Sensoril ® also helps modulate the stress response,15-18 which has a negative impact on cortisol excretion. Stress can be very damaging to the brain, especially memory function, and cortisol stimulates the body to release sugar (glucose) into the bloodstream.19-23

Cognitex® additionally provides a NeuroProtection Complex consisting of standardized extracts of hops and rosemary that help suppress pro-inflammatory cytokines.24,25

Circulation and Cognitive Health

Brain cells such as neurons are fed by blood vessels. Some of these micro-capillaries can be so small that red blood cells carrying oxygen have difficulty passing through them. Neurons are the key structure for cognitive functions including memory. Vinpocetine enhances blood flow by dilating blood vessels and reducing blood viscosity. Vinpocetine enhances cerebral metabolism by helping to maintain healthy blood flow and glucose levels in those already within normal range, which enhances oxygen utilization.26-29

Boosting the Acetylcholine Neurotransmitter

Alpha-glyceryl phosphoryl choline (Alpha-GPC), an acetylcholine precursor, is naturally present in all the body’s cells. Its importance to life and safety as a supplement is evidenced by its substantial presence in human breast milk.30,31

Acetylcholine is an essential neurotransmitter involved in muscle control, sleep, and cognition. Acetylcholine decline coincides with advancing age, and is a hallmark of neurodegenerative decline. Alpha-GPC is crucial for the production of acetylcholine in the brain.

Alpha-GPC also plays a key role in both the synthesis and the catabolic recycling of phospholipids in the brain and supports healthy brain function. 32-35 Alpha-GPC may positively affect phospholipid synthesis, including the phosphoinositides available for signal transduction at central nervous system level.30

Cognitex® is also available with pregnenolone. Concentrations of this critical hormone are much higher in the brain, and studies show that pregnenolone has numerous mental benefits. All these ingredients work synergistically to promote optimal cognitive function.

A bottle containing 90 softgels of Cognitex®, with and without pregnenolone, retails for $74 and $72, respectively. If a member purchases four or more bottles, the price drops to $49.95 each and $48 each, respectively. If a member purchases eight or more bottles, the price per bottle with or without pregnenolone drops to $44.17 each and $42.72 each, respectively.

Life Extension also offers the value-priced Cognitex® Basics, for members who want a more cost-effective cognitive support product. For more information on all three Cognitex® versions please refer to the Brain section of this Directory.

Caution: Pregnenolone may affect levels of other hormones, such as progesterone, estrogen, testosterone and/or DHEA. Do not take this product if you have a history of seizures. Do not take this product if you have breast cancer, prostate cancer, or other hormone-sensitive diseases. If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult with your physician before using this product.

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