Recommendation Number 3

Super Ubiquinol CoQ10

DOSAGE: 1 softgel with food and a glass of water once or twice daily.

Maintain Optimal CoQ10 Blood Levels

Life Extension introduced coenzyme Q10 to the U.S. back in 1983. Since then we have consistently introduced more potent, more absorbable forms of this critical nutrient. The reason is simple.

About 95% of cellular energy is produced from structures in your cells called mitochondria. Coenzyme Q10 is incorporated into the mitochondria of your cells where it facilitates the transformation of fats and sugars into energy. A large body of scientific evidence shows that CoQ10’s ability to restore mitochondrial function has a profound effect on one’s overall health.1,2 Coenzyme Q10 produces beneficial effects to the heart,3-21 brain,3,22-26 kidneys,27-29 and other tissues.3,7,30-40

The Ubiquinol Form of CoQ10

Ubiquinol is the biologically superior form of CoQ10 because it’s an electron donor, which makes it a very effective neutralizer of free radicals and the only form of CoQ10 that scavenges lipid peroxyl radicals that can damage the polyunsaturated fatty acids of your cell membranes. Ubiquinol also contains two hydroxyl groups instead of one, which allows it to bond with water and makes it more readily absorbable by the mitochondria of your cells for energy production.41

Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™

When CoQ10 levels diminish, the ability of cells to sustain even basic metabolic functions is impaired. So Life Extension has taken the biologically superior ubiquinol form of CoQ10 and combined it with an organic compound called PrimaVie® Shilajit that research shows doubles levels of CoQ10 in the mitochondria.42 Shilajit has been shown to restore and sustain cellular energy.

Shilajit and Mitochondrial Metabolism

Scientific analysis shows that shilajit itself is rich in essential compounds that promote mitochondrial metabolism. Part of its beneficial effects derive from its ability to help the mitochondria convert fats and sugars into adenosine triphosphate, or ATP … the cell’s main source of energy. Combining ubiquinol CoQ10 with shilajit generates a powerful synergy that supports more youthful cellular energy production than CoQ10 alone.

CoQ10 Plus Shilajit

The latest studies show that when shilajit is combined with CoQ10, cellular energy gains substantially increase. In a breakthrough preliminary study, combining CoQ10 with shilajit produced a 56% increase in cellular energy production in the brain (40% better than CoQ10 alone) … and 144% increase in muscle (27% better than CoQ10 alone).43

Researchers have found that shilajit works to boost CoQ10’s beneficial effects two ways:

  1. By stabilizing CoQ10 in its superior ubiquinol form, thereby prolonging its action at the cellular level.44,45
  2. And by facilitating more efficient delivery of CoQ10 into the mitochondria, resulting in greater cellular energy output.46-50

CoQ10 and Statin Drugs

Heart cells have a high-energy demand, and many clinical studies have investigated the role of CoQ10 on cardiac function. Efficacy has been shown in studies when CoQ10 was used for cardiovascular problems.51,52 Scientists have also found that CoQ10 provides benefits to other organs whose cells require high-level energy metabolism such as the brain and kidneys.1,53,54

One reason more people supplement with coenzyme Q10 now than ever before is the increased awareness that statin drugs (used to lower LDL and cholesterol) deplete the body of CoQ10.55-59

Normal aging, however, can result in an even greater reduction in CoQ10 than that caused by statin drugs.60-64 While statin drugs have been shown to reduce blood plasma levels of CoQ10 by 40%, the aging process can reduce CoQ10 levels in your heart muscle wall by 72%.65

Demonstrated Effectiveness for a Healthier Heart

Findings at the 5th Annual International CoQ10 Symposium held in Kobe, Japan, demonstrated the remarkable superiority of ubiquinol in a group of seriously ill patients with advanced-stage cardiac disorders. This interesting study revealed that clinically ill patients who suffered from severe heart failure readily absorbed ubiquinol CoQ10 into their bloodstreams and displayed much greater health benefits.66

The retail price for a 100-count bottle of 50-mg Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™ is $58.00. If a member of the Life Extension Foundation buys four bottles, the price is reduced to $39.75 per bottle. Each bottle lasts most people about two months based on taking one capsule twice a day.

Some members who want to take higher doses use the 100mg or 200 mg size of this unique formulation. The retail price for a bottle containing 60 softgels of 100 mg Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™ is $62.00. A 30-count bottle of 200 mg softgels also retails for $62.00. If a member buys four bottles, the price is reduced to $42.00 per bottle. The significantly higher cellular energy gains make these novel CoQ10 formulations a tremendous value “per absorbed milligram.”

PrimaVie® is a registered trademark of Natreon, Inc.

More Info on Coenzyme Q10 (CoQ10) Supplements

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References

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3. Curr Neurovasc Res. 2005 Dec;2(5):447-59.

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24. Proc Natl Acad Sci USA. 1998 Jul 21;95(15):8892-7.

25. Brain Res. 1998 Feb 2;783(1):109-14.

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39. Surgery. 1982 Jun;91(6):631-7.

40.  Wilkinson EG, Arnold RM, Folkers K, Hansen I, Kishi H. Bioenergetics in clinical medicine. II. Adjunctive treatment with coenzyme Q in periodontal therapy. Res

41. Mol Aspects Med. 1994;15 Suppls 97-102.

42.  Systemic CoQ level in animals: Part II. Unpublished study. Natreon, Inc.; 2007.

43.  Pharmacologyonline. 2009;1:817-25.

44.  Pharmacologyonline. 2009;2:690-8.

45. Electronic Journal of Biotechnology. 2008 Jul 15;11(3).

46.  Ghosal S. Shilajit in Perspective. Alpha Science International Limited; 2006.

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55. Mitochondrion. 2007 Jun;7 Suppl:S168-74. Epub 2007 Mar 27. Review.

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65. J Clin Pharmacol. 1993 Mar;33(3):226-9.

66.  Langsjoen and Langsjoen AM. Supplemental ubiquinol in patients with advanced congestive heart failure. 2007. Presented at 5th International CoQ10 conference. Kobe, Japan.

Top Ten Item
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Top Ten Recommendation
Top Ten Nutritional Supplements
1: Multivitamins and Minerals (Life Extension Mix™)
2: Omega-3 Fatty Acids (Fish Oil)
3: Coenzyme Q10 (CoQ10)
4: Mitochondrial Function (MEO)
5: Hormone Balance (DHEA)
6: Brain Cell Function (Cognitex)
7: Bone Health (for women and men)
7A: Prostate Health (for men only)
8: Neural and Hepatic Health (SAMe)
9: Vitamin D Levels (Vitamin D3)
10: Vitamin K, Gamma Tocopherol (Super Booster Softgels)

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