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Recommendation Number 3:

Super Ubiquinol CoQ10

DOSAGE: 1 softgel with food and a glass of water once or twice daily.

Maintain Optimal CoQ10 Blood Levels With Coenzyme Q10 Supplements

Life Extension introduced coenzyme Q10 to the U.S. back in 1983. Since then we have consistently introduced more potent, more absorbable forms of this critical nutrient. The reason is simple.

About 95% of cellular energy is produced from structures in your cells called mitochondria. Coenzyme Q10 is incorporated into the mitochondria of your cells where it facilitates the transformation of fats and sugars into energy. A large body of scientific evidence shows that CoQ10’s ability to restore mitochondrial functionhas a profound effect on one’s overall health.1,2 Coenzyme Q10 produces beneficial effects to the heart,3-21 brain,3,22-26 kidneys,27-29 and other tissues.3,7,30-40

The ubiquinol form of CoQ10

Ubiquinol is the biologically superior form of CoQ10 because it’s an electron donor, which makes it a very effective neutralizer of free radicals and the only form of CoQ10 that scavenges lipid peroxyl radicals that can damage the polyunsaturated fatty acids of your cell membranes. Ubiquinol also contains two hydroxyl groups instead of one, which allows it to bond with water and makes it more readily absorbable by the mitochondria of your cells for energy production.41

New Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™

When CoQ10 levels diminish, the ability of cells to sustain even basic metabolic functions is impaired. So Life Extension has taken the the biologically superior ubiquinol form of CoQ10 and combined it with an organic compound called PrimaVie® shilajit that research shows doubles levels of CoQ10 in the mitochondria.42 Shilajit has been shown to restore and sustain cellular energy,

Shilajit and mitochondrial metabolism

Scientific analysis shows that shilajit itself is rich in essential compounds that promote mitochondrial metabolism. Part of its beneficial effects derive from its ability to help the mitochondria convert fats and sugars into adenosine triphosphate, or ATP… the body’s main source of energy. Combining ubiquinol CoQ10 with shilajit generates a powerful synergy that supports more youthful cellular energy production than CoQ10 alone.

CoQ10 plus shilajit

The latest studies show that when shilajit is combined with CoQ10, cellular energy gains substantially increase. In a breakthrough preliminary study, combining CoQ10 with shilajit produced a 56% increase in cellular energy production in the brain (40% better than CoQ10 alone) … and 144% increase in muscle (27% better than CoQ10 alone).43

Researchers have found that shilajit works to boost CoQ10’s beneficial effects two ways:

By stabilizing CoQ10 in its superior ubiquinol form, thereby prolonging its action at the cellular level.44,45
And by facilitating more effcicient delivery of CoQ10 into the mitochondria, resulting in greater cellular energy output.46-50

CoQ10 supplements and Statin Drugs

Heart cells have a high-energy demand, and many clinical studies have investigated the role of CoQ10 on cardiac function. Efficacy has been shown in studies when CoQ10 was used for cardiovascular problems.51,52 Scientists have also found that CoQ10 provides benefits to other organs whose cells require high-level energy metabolism such as the brain and kidneys.1,53,54

One reason more people supplement with coenzyme Q10 now than ever before is the increased awareness that statin drugs (used to lower LDL and cholesterol) deplete the body of CoQ10.55-59

Normal aging, however, can result in an even greater reduction in CoQ10 than that caused by statin drugs.60-64 While statin drugshave been shown to reduce blood plasma levels of CoQ10 by 40%, the aging processcan reduce CoQ10 levels in your heart muscle wall by 72%.65

Demonstrated Effectiveness for a Healthier Heart

Findings at the 5th Annual International CoQ10 Symposium held in Kobe, Japan, demonstrated the remarkable superiority of ubiquinol in a group of seriously ill patients with advanced-stage cardiac disorders. This interesting study revealed that clinically ill patients who suffered from severe heart failure readily absorbed ubiquinol CoQ10 into their bloodstreams and displayed much greater health benefits.66

Improved formulation, same low price!

Life Extension has added PrimaVie® shilajit to its Super Ubiquinol CoQ10 formulation without increasing the price. So you get a more effective CoQ10 at the same low price. The retail price for a 100-count bottle of 50-mg Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™ is $58.00. If a member of the Life Extension Foundation buys four bottles, the price is reduced to $39.75 per bottle. Each bottle lasts most people about two months based on taking one capsule twice a day.

Some members who want to take higher doses use the 100-mg size of this unique formulation. The retail price for a bottle of 60 100-mg Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™ caps is $62.00. If a member buys four bottles, the price is reduced to $42.00 per bottle. The significantly higher cellular energy gains make this novel CoQ10 formulation a tremendous value “per absorbed milligram.”

More Info on Coenzyme Q10 (CoQ10) Supplements

Maintain Optimal CoQ10 Blood Levels With Coenzyme Q10 Supplements

Top Ten Nutritional Supplements

1: Multivitamins and Minerals
(Life Extension Mix™)

2: Omega-3 Fatty Acids (Fish Oil)

3: Coenzyme Q10 (CoQ10)

4: Mitochondrial Function (MEO)

5: Hormone Balance (DHEA)

6: Brain Cell Function (Cognitex)

7: Bone Health (for women and men)

7a: Prostate Health (for men only)

8: Neural and Hepatic Health (SAMe)

9: Cardiovascular Health (Aspirin)

10: Vitamin K, Gamma Tocopherol (Super Booster Softgels)

References

1. Matthews RT, Yang L, Browne S, Baik M, Beal MF. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA. 1998 Jul 21;95(15):8892-7.

2. Menke T, Gille G, Reber F, et al. Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential. Biofactors. 2003;18(1-4):65-72.

3. Dhanasekaran M, Ren J. The emerging role of coenzyme Q-10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus. Curr Neurovasc Res. 2005 Dec;2(5):447-59.

4. Wang XL, Rainwater DL, Mahaney MC, Stocker R. Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons. Am J Clin Nutr. 2004 Sep;80(3):649-55.

5. Rosenfeldt FL, Pepe S, Linnane A, et al. Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients. Ann NY Acad Sci. 2002 Apr;959:355-9.

6. Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002 Nov;56(11):1137-42.

7. Gaby AR. The role of coenzyme Q10 in clinical medicine: Part II. Cardiovascular disease, hypertension, diabetes mellitus and infertility.Altern Med Rev. 1996:1:168-75.

8. Singh RB, Niaz MA. Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role. Int J Cardiol. 1999 Jan;68(1):23-9.

9. Singh RB, Niaz MA, Rastogi SS, Shukla PK, Thakur AS. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens. 1999 Mar;13(3):203-8.

10. Baggio E, Gandini R, Plancher AC, Passeri M, Carmosino G. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med. 1994;15 Suppls287-94.

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19. Langsjoen PH, Vadhanavikit S, Folkers K. Effective treatment with coenzyme Q10 of patients with chronic myocardial disease. Drugs ExpClin Res. 1985;11(8):577-9.

20. Furuta T, Kodama I, Kondo N, Toyama J, Yamada K. A protective effect of coenzyme Q10 on isolated rabbit ventricular muscle under hypoxic condition. J Cardiovasc Pharmacol. 1982 Nov;4(6):1062-7.

21. Yamagami T, Shibata N, Folkers K. Bioenergetics in clinical medicine. VIII. Adminstration of coenzyme Q10 to patients with essential hypertension. Res Commun Chem Pathol Pharmacol. 1976 Aug;14(4):721-7.

22. Somayajulu M, McCarthy S, Hung M, et al. Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis. 2005 Apr;18(3):618-27.

23. Menke T, Gille G, Reber F, et al. Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential. Biofactors. 2003;18(1-4):65-72.

24. Matthews RT, Yang L, Browne S, Baik M, Beal MF. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA. 1998 Jul 21;95(15):8892-7.

25. Beal MF, Matthews RT, Tieleman A, Shults CW. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res. 1998 Feb 2;783(1):109-14.

26. Ren Z, Ding W, Su Z, et al. Mechanisms of brain injury with deep hypothermic circulatory arrest and protective effects of coenzyme Q10. J Thorac Cardiovasc Surg. 1994 Jul;108(1):126-33.

27. Gazdikova K, Gvozdjakova A, Kucharska J et al. [Effect of coenzyme Q10 in patients with kidney diseases]. Cas Lek Cesk. 2001 May 24;140(10):307-310.

28. Okamoto H, Kawaguchi H, Togashi H, et al. Effect of coenzyme Q10 on structural alterations in the renal membrane of stroke-prone spontaneously hypertensive rats. Biochem Med Metab Biol. 1991 Apr;45(2):216-26.

29. Takenaka M, Tatsukawa Y, Dohi K, et al. Protective effects of alphatocopherol and coenzyme Q10 on warm ischemic damages of the rat kidney. Transplantation. 1981 Aug;32(2):137-41.

30. Feher J, Kovacs B, Kovacs I, et al. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Ophthalmologica. 2005 May;219(3):154-66.

31. Quiles JL, Farquharson AJ, Ramirez-Tortosa MC, et al. Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells. Biofactors. 2003;18(1-4):265-70.

32. Miquel J. Can antioxidant diet supplementation protect against age-related mitochondrial damage? Ann NY Acad Sci. 2002 Apr;959:508-16.

33. Linnane AW, Zhang C, Yarovaya N, et al. Human aging and global function of coenzyme Q10. Ann NY Acad Sci. 2002 Apr;959:396-411.

34. Linnane AW, Kopsidas G, Zhang C, et al. Cellular redox activity of coenzyme Q10: effect of CoQ10 supplementation on human skeletal muscle. Free Radic Res. 2002 Apr;36(4):445-53.

35. Hoppe U, Bergemann J, Diembeck W, et al. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 1999;9(2-4):371-8.

36. Hanioka T, Tanaka M, Ojima M, Shizukuishi S, Folkers K. Effect of topical application of coenzyme Q10 on adult periodontitis. Mol Aspects Med. 1994;15 Suppls241-8.

37. Folkers K and Wolaniuk A. Research on coenzyme Q10 in clinical medicine and in immunomodulation. Drugs Exp Clin Res. 1985;11(8):539-45.

38. Suzuki H, Naitoh T, Kuniyoshi S, et al. Cardiac performance and coenzyme Q10 in thyroid disorders. Endocrinol Jpn. 1984 Dec;31(6):755-61.

39. Marubayashi S, Dohi K, Ezaki H, Hayashi K, Kawasaki T. Preservation of ischemic rat liver mitochondrial functions and liver viability with CoQ10. Surgery. 1982 Jun;91(6):631-7.

40. Wilkinson EG, Arnold RM, Folkers K, Hansen I, Kishi H. Bioenergetics in clinical medicine. II. Adjunctive treatment with coenzyme Q in periodontal therapy. Res

41. Weber C, Jakobsen TS, Mortensen SA, Paulsen G, Holmer G. Effect of dietary coenzyme Q10 as an antioxidant in human plasma. Mol Aspects Med. 1994;15 Suppls 97-102.

42. Systemic CoQ level in animals: Part II. Unpublished study. Natreon, Inc.; 2007.

43. Pharmacologyonline. 2009;1:817-25.

44. Pharmacologyonline. 2009;2:690-8.

45. Electronic Journal of Biotechnology. 2008 Jul 15;11(3).

46. Ghosal S. Shilajit in Perspective. Alpha Science International Limited; 2006.

47. Sci Total Environ. 1987 Apr;62:347-54.

48. Environ Sci Technol. 2002 Jul 15;36(14):3170-5.

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50. Environ Sci Technol. 2009 Feb 1;43(3):878-83.3.

51. Greenberg S, Frishman WH. Coenzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol. 1990 Jul;30(7):596-608.

52. Witting PK, Pettersson K, Letters J, et al. Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice. Free Radic Biol Med. 2000 Aug;29(3-4):295-305.

53. Gazdikova K, Gvozdjakova A, et al. Effect of coenzyme Q10 in patients with kidney diseases. Cas Lek Cesk. 2001 May 24;140(10):307-10.

54. Naini A, Lewis VJ, Hirano M, et al. Primary coenzyme Q10 deficiency and the brain. Biofactors. 2003;18(1-4):145-52.

55. Littarru GP, Langsjoen P. Coenzyme Q10 and statins: biochemical and clinical implications. Mitochondrion. 2007 Jun;7 Suppl:S168-74. Epub 2007 Mar 27. Review.

56. Passi S, Stancato A, Aleo E, et al. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. Biofactors. 2003;18(1-4):113-24.

57. Langsjoen PH, Langsjoen AM. The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human publications. Biofactors. 2003;18(1-4):101-11.

58. Mabuchi H, Higashikata T, Kawashiri M, Katsuda S, Mizuno M, Nohara A, Inazu A, Koizumi J, Kobayashi J. Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients. J Atheroscler Thromb. 2005;12(2):111-9.

59. Mortensen SA, Leth A. et al. Dose-related decrease of serum CoQ10 during treatment with HMG-CoA reductase inhibitors. Mol Aspect Med. 1997; 1&(S):137-144.

60. Blatt T, Lenz H, Koop U, et al. Stimulation of skinís energy metabolism provides multiple benefits for mature human skin. Biofactors. 2005;25(1-4):179-85. Review.

61. Pignatti C, Cocchi M, Weiss H. Coenzyme Q10 levels in rat heart of different age. Biochem Exp Biol. 1980;16(1):39-42.

62. Willis R, Anthony M, Sun L, Honse Y, Qiao G. Clinical implications of the correlation between coenzyme Q10 and vitamin B6 status. Biofactors. 1999;9(2-4):359-63.

63. Hoppe U, Bergemann J, et al. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 1999;9(2-4):371-8.

64. Rosenfeldt FL, Pepe S, Ou R, Mariani JA, Rowland MA, Nagley P, Linnane AW. Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue. Biofactors. 1999;9(2-4):291-9.

65. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. J Clin Pharmacol. 1993 Mar;33(3):226-9.

66. Langsjoen and Langsjoen AM. Supplemental ubiquinol in patients with advanced congestive heart failure. 2007. Presented at 5th International CoQ10 conference. Kobe, Japan.

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