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Recommendation Number 3:
Super Ubiquinol CoQ10

DOSAGE: 1 softgel with food and a glass of water once or twice daily.

Maintain Optimal CoQ10 Blood Levels With Supplements

About 95% of cellular energy is produced from structures in your cells called mitochondria. Coenzyme Q10 is incorporated into the mitochondria of your cells where it facilitates the transformation of fats and sugars into energy. A large body of scientific evidence shows that CoQ10’s ability to restore mitochondrial function has a profound effect on one’s overall health.79,80

When CoQ10 levels diminish, the ability of cells to sustain even basic metabolic functions is impaired.

Heart cells have a high-energy demand, and many clinical studies have investigated the effect of CoQ10 on cardiac function. Efficacy has been shown in studies when CoQ10 was used for cardiovascular problems81,82 Scientists have also found that CoQ10 provides benefits to other organs whose cells require high-level energy metabolism such as the brain and kidneys.79, 83,84

CoQ10 and Statin Drugs

One reason why more people supplement with coenzyme Q10 now than ever before is the increased awareness that the “statin” drugs (used to lower LDL and cholesterol) deplete the body of CoQ10.85-89

Normal aging, however, can result in an even greater reduction in CoQ10 than that caused by statin drugs.90-94 While statin drugs have been shown to reduce blood plasma levels of CoQ10 by 40%, the aging process can reduce CoQ10 levels in your heart muscle wall by 72%.95

Taking the Proper Form of CoQ10

When it comes to obtaining optimal benefits, it is not how much CoQ10 you swallow, but how much you absorb that counts.

In recent years, new delivery systems have enabled more CoQ10 to be transported into the bloodstream. Delivering these greater amounts is of critical importance, since scientific studies show that higher CoQ10 blood levels produce vastly superior benefits.

What you’re about to learn, however, could radically change your life. Not only is it now possible to achieve higher sustained CoQ10 blood levels than ever before, but this new form of CoQ10 has demonstrated unparalleled age-delaying effects.

Ubiquinol versus Ubiquinone CoQ10

Scientists long ago discovered that coenzyme Q10 produces beneficial effects to the heart96-114 brain,96,115-119 kidneys,120-122 and other tissues.96,100,123-133

What few doctors know, however, is that for ubiquinone CoQ10 to be utilized, it first has to be reduced in the body to its active metabolite called ubiquinol. While most ubiquinone is naturally reduced to ubiquinol in the body, the optimal way to supplement with CoQ10 is to ingest it in its ready-to-use ubiquinol form.

Since ubiquinol is highly unstable, it has been difficult (up until now) to make it available as a dietary supplement. After years of research, the largest Japanese producer of coenzyme Q10 has developed a patented method to stabilize ubiquinol so that it can be taken in capsule form for utilization throughout the body.134

The ramifications of the widespread use of this novel form of CoQ10 are profound. For the first time, it is possible to achieve the sustained high blood levels of biologically active ubiquinol CoQ10 needed to delay certain manifestations of aging.

Sharply Increased Blood CoQ10 Levels Means Increased Benefits for Cardiovascular Health

Click to Enlarge

Even with today’s enhanced delivery systems, absorbing optimal amounts of CoQ10 into the bloodstream can be challenging. Those suffering from problems that require higher blood levels need to consume relatively large doses of CoQ10. Ideal blood levels for those afflicted with common age-related problems are considered to be greater than 3.5 micrograms per milliliter (mcg/mL).135

When CoQ10 is ingested in its reduced form (ubiquinol), higher blood CoQ10 levels can be achieved using smaller milligram doses. In assimilation studies on rats, oral feeding of ubiquinol CoQ10 was shown to increase blood levels more than twice as high as conventional CoQ10 (ubiquinone).136,137 Human assimilation studies are even more impressive.

A four-week human trial showed that supplementing with just 150 mg/day of ubiquinol resulted in CoQ10 blood levels of 3.84 mcg/mL.

To put this blood level in perspective, human clinical trials have been conducted using very high doses of conventional CoQ10 in enhanced delivery systems. These published human studies reveal that it requires eight times more conventional CoQ10 to achieve the same blood levels (around 3.84 mcg/mL) attainable with modest amounts of ubiquinol CoQ10.138-141 The accompanying chart clearly shows how little ubiquinol is needed to provide the same high blood levels that are achieved in response to far greater amounts of ubiquinone.

Human studies show that ubiquinol which increases blood CoQ10 levels bioavailablity up to eight times more efficiently, by comparison to different clinical studies with ubiquinone.142 This chart shows that only 150 mg of ubiquinol increased blood levels to a similar level attained using 1200 mg of ubiquinone. (Note that using data from another study, it took 2400 mg of ubiquinone CoQ10 to reach blood levels achieved with only 300 mg of ubiquinol.)

In year 2006, Life Extension introduced this revolutionary new stabilized form of ubiquinol CoQ10 from Japan that has been suggested in comparing studies that may have bioavailability up to eight times better142 , but achieved 3.75 times higher plasma concentrations after eight hours than conventional ubiquinone CoQ10. This higher sustained blood level enabled ubiquinol to reduce fatigue 90% more effectively143 and slow aging 40% better144 than ordinary ubiquinone.

Ubiquinol is the biologically superior form of CoQ10 because it’s an electron donor, which makes it a very effective neutralizer of free radicals and the only form of CoQ10 that scavenges lipid peroxyl radicals that can damage the polyunsaturated fatty acids of your cell membranes. Ubiquinol also contains two hydroxyl groups145 instead of one, which allows it to bond with water and makes it more readily absorbable by the mitochondria of your cells for energy production.

Demonstrated Effectiveness for a Healthier Heart

Findings recently released at the 5th Annual International CoQ10 Symposium held in Kobe, Japan, have demonstrated the remarkable superiority of ubiquinol in a group of seriously ill patients with advanced-stage cardiac disorders. This interesting study revealed that these clinically ill patients who suffered from severe heart failure had great difficulty assimilating ubiquinone, but that ubiquinol was readily absorbed into their bloodstream and displayed much greater health benefits.

Now Improved with an New Delivery Technology—Available First from Life Extension

Not satisfied with producing the world’s best CoQ10, the Japanese scientists who perfected stabilized ubiquinol have just patented a new delivery system that enables even more ubiquinol to be absorbed into your bloodstream. This enhanced delivery technology has been shown to double peak CoQ10 blood levels (a 100% increase in absorption) and leave 66% more CoQ10 in your bloodstream after 24 hours than the original formula! This improved performance provides greater health benefits than ever before. And, what’s even more astounding—it actually costs less!

The retail price for a 100-count bottle of 50 mg Super Ubiquinol CoQ10 with its advanced delivery system is $58.00. If a member of the Life Extension Foundation buys four bottles, the price is reduced to $39.75 per bottle. Each bottle lasts most people about two months based on taking one capsule twice a day.

Some members want to take higher doses and use 100 mg Super Ubiquinol CoQ10. The retail price for a bottle of 60 100 mg Super Ubiquinol CoQ10 caps is $62.00. If a member buys four bottles, the price is reduced to $42.00 per bottle. The significantly higher absorption rates of ubiquinol CoQ10 make it a tremendous value “per absorbed milligram”.

More Info on Coenzyme Q10 (CoQ10)

Maintain Optimal CoQ10 Blood Levels With Supplements

Top Ten Nutritional Supplements

1: Multivitamins and Minerals
(Life Extension Mix™)

2: Omega-3 Fatty Acids (Fish Oil)

3: Coenzyme Q10 (CoQ10)

4: Mitochondrial Function (MEO)

5: Hormone Balance (DHEA)

6: Brain Cell Function (Cognitex)

7: Bone Health (for women and men)

7a: Prostate Health (for men only)

8: Neural and Hepatic Health (SAMe)

9: Cardiovascular Health (Aspirin)

10: Vitamin K, Gamma Tocopherol (Super Booster Softgels)

References

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105. Greenberg S, Frishman WH. Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol. 1990 Jul;30(7):596-608.

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116. Menke T, Gille G, Reber F, et al. Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential. Biofactors. 2003;18(1-4):65-72.

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136. Ubiquinol has a higher bioavailability compared to ubiquinone. Unpublished data, Kaneka Corp.

137. Plasma levels of COQ10 for ubiquinol increased dose dependently. Unpublished data, Kaneka Corp.

138. Hosoe K, Kitano M, Kishida H, et al. Study on safety and bioavailability of ubiquinol (Kaneka QH(trade mark)) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28. Epub 2006 Aug 21.

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142. Hosoe K, Kitano M, Kishida H, et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28.

143. KANEKA CORP. Anti-fatigue effect in rats. Unpublished data, Kaneka Corp.

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*These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.

The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.