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Recommendation Number 1:

Life Extension Mix™

Best Multivitamin-Mineral-Herbal-Amino Acid Formula Now with Pterostilbene and more Vitamin D

DOSAGE: 9 tablets per day in divided doses with meals. (Also available in capsule and powder forms.)

Don't Die From Multivitamin Deficiency

An abundance of published scientific research reveals that many common problems afflicting the aged are attributable to a lack of specific nutrients in the diet. Considering that low-cost supplements are available to guard against these deficiency syndromes, it amounts to personal negligence if one does not at least take their basic daily vitamins and minerals.

Few doctors are aware of how shockingly deficient Americans are in essential nutrients. We are not talking about the benefits of taking higher-potency vitamin supplements right now. Instead, we are down to the fundamental fact that the vast majority of Americans fail to obtain even the tiny amount of nutrients in their diets that the medical establishment itself says are needed.

For example, over the past several years scientists have validated the critical role vitamin D plays in regulating a host of bodily functions. These new findings link insufficient blood levels of vitamin D to common age-related problems. Startling evidence of this widespread vitamin D insufficiency has led to recommendations for Americans to increase their vitamin D intake to 1,000 IU per day and higher. While most multivitamin supplements contain only 400 IU of vitamin D, Life Extension has upped that to 2,000 IU in both the comprehensive multi-nutrient Life Extension Mix™ and the multivitamin Two-Per-Day formulas.

The largest study ever conducted on dedicated supplement users showed a startling 85% had less than optimal blood levels.1 This and other reports led the Life Extension Foundation to recommend that most of its aging members supplement with a total of 7,000 IU (and higher) of vitamin D3 daily with the objective of achieving 25-hydroxyvitamin D blood levels greater than 50 ng/mL.

Additionally, many Americans supplement with around 400 IU of vitamin E to obtain what they believe are optimal antioxidant benefits from this particular nutrient. The federal government, however, says that only 15 mg of vitamin E (in the form of alpha tocopherol) are needed. The world’s respected Journal of Nutrition says that 93% of American men and 96% of American women do not even consume the federal government’s recommended 15 mg of vitamin E in their diets!2 This means that virtually all Americans who fail to supplement are at serious risk of suffering a vitamin E deficiency.

How Dangerous Is It To Be Deficient In Vitamin E?

In November of 2006, the largest study in medical history was published using blood levels of vitamin E (alpha tocopherol) as the marker of vitamin E status. The purpose of this study was to correlate baseline vitamin E levels with specific causes of death and overall mortality with a follow up over a 19-year period. There were 29,000 subjects initially enrolled and 13,380 deaths available for analysis.3 The study results showed a significant reduction in overall mortality in those with the highest blood levels of vitamin E.

Based on these statistics, an editorial published in this same journal asked why doctors ever questioned the importance of vitamin E supplements?4 The editorial went on to emphasize the importance of obtaining the amount of vitamin E necessary. When analyzing fine details of this largest human study on vitamin E, the editors stated that the amount of this nutrient needed to achieve the optimal results could be achieved “only with supplements.”

Vitamin E Deficiency Accelerates Age-Related Decline

In the January 23, 2008, edition of the Journal of the American Medical Association, the findings from a study that measured vitamin E levels in people 65 years and older was published. The results showed that those with the lowest blood levels of vitamin E were 60% more likely to suffer physical decline over the three-year follow-up period.5

The study’s authors concluded: “These results provide empirical evidence that a low serum concentration of vitamin E is associated with subsequent decline in physical function among community-living older adults.”

Vitamin E Is Only One of Many Deficient Nutrients

Sadly, most diets fail to provide even the minimum amounts of nutrients even according to the low government recommended daily intakes. As a result, Americans suffer egregious deficits of vital nutrients such as magnesium, potassium,6 vitamin B6, vitamin B57 and vitamin D.8

Fortunately, it is easy to obtain potent doses of these basic nutrients in multi-nutrient formulas.

The Latest Life Extension Mix™ Now with Pterostilbene and more Vitamin D

Despite constant media publicity aimed at consumers by government health agencies and private organizations, the majority of Americans still do not eat enough fruits and vegetables every day. Increasingly, scientists are telling Americans that they must consume these kinds of plants in order to avoid a host of age-related problems.

Now, as part of a formulation that already provides the world’s broadest spectrum of plant extracts, Life Extension Mix™ also includes trans-pterostilbene, a compound found naturally in blueberries and grapes that has been shown to have beneficial effects on gene expression and to promote healthy cognitive function. In the words of Dr. Agnes M. Rimando, a leading expert in the biology of stilbenes (resveratrol, pterostilbene and other related compounds), “Stilbenes have diverse pharmacological activities which include enhanced insulin sensitivity and increased life span.”9

Standardized Cocoa Polyphenol Extract

The public does not attribute the cocoa bean with the same health benefits as broccoli or berries. Research shows, however, that the unique polyphenols found in cocoa provide broad-spectrum benefits to the arterial system.

In fact, cocoa polyphenols have been clinically proven to not only support healthy insulin levels, but also help maintain healthy lipid levels for those within normal range, inhibit LDL oxidation, and help maintain already normal blood pressure and arterial blood flow by restoring endothelial function.10-19 Based on these groundbreaking studies, a standardized cocoa polyphenol extract is a vital part of the Life Extension Mix™ formula.

Along with over two dozen other fruit and vegetable extracts, Life Extension Mix™ provides high-potency vitamins, minerals, and amino acids that form the cornerstone of a comprehensive health maintenance program.

Standardized Pomegranate Extract

The pomegranate extract contained in Life Extension Mix™ is standardized to provide the biologically active punicalagins that are so unique to this fruit.

Pomegranate punicalagins are 100% water-soluble and have shown a remarkable 95% absorption rate.20 When tested against popular antioxidant food extracts, pomegranate demonstrated the most potent free radical-suppressing effects. This means that pomegranate punicalagins not only absorb much better than other natural antioxidants, but they also have a superior antioxidant capacity.

Like cocoa polyphenols, peer-reviewed published human and animal studies show that pomegranate helps maintain healthy cardiovascular function.21-24 Pomegranate also has the unique property of helping to maintain healthy DNA structure in the prostate cells.25-27

The daily dose of Life Extension Mix™ provides the equivalent of consuming up to 2.6 ounces of pomegranate juice — without the sugar calories.

Standardized Blueberry Extracts

Blueberry anthocyanins are potent antioxidants that have demonstrated properties that extend well beyond suppressing free radicals.

For instance, blueberries have been shown to not only improve memory, but to also help with some of the degenerative changes seen in aging neurons.28 One study showed that the ability of blueberries to suppress free radicals and inflammation in the rat brain was analogous to long-term calorie restriction.29 These findings hint that blueberries might be able to reverse certain aspects of brain aging!

Blueberry’s other active constituent (pterostilbene) helps maintain already normal lipid and glucose levels.30 Even more exciting is that these blueberry constituents (pterostilbene and anthocyanins) may help maintain healthy DNA structure.31,32

Life Extension Mix™ contains standardized blueberry extracts that provide the most active constituents found in this health-promoting fruit.

Standardized Green Tea Extract

The Life Extension Foundation® introduced green tea extract as a supplement in 1993 based on epidemiological studies showing that people who consumed green tea had lower incidences of common health issues.33 Over the past 17 years, an enormous volume of positive studies has been published about the health benefits of green tea.

Scientists have looked at the active polyphenol constituents of green tea and have found that they possess remarkable biological activities that include inhibiting LDL oxidation and neuronal peroxidation, while maintaining healthy DNA structure.34-40

Life Extension Mix™ contains 325 mg of a decaffeinated green tea extract that is standardized to provide 98% of the active polyphenols that scientists attribute to green tea’s multiple health benefits.

The amount of polyphenols [including epigallocatechin-3-gallate (EGCG)] in Life Extension Mix™ is equivalent to drinking about three to four cups of green tea per day.

Standardized Vegetable Extracts

Luteolin is a flavonoid found in parsley, artichoke, basil, celery, and other foods. When measured against 27 other flavonoids, luteolin provided one of the highest levels of DNA protection.41

One favorable mechanism of luteolin is its ability to inhibit oxidative damage to cellular DNA. Another unique benefit is luteolin’s ability to suppress excess levels of dangerous inflammatory cytokines such as interleukin-6 and interleukin-1b.42,43

Life Extension Mix™ contains a standardized dose of 8 mg of luteolin, a dose that emulates the benefits seen in published scientific studies.

Broccoli is touted as one of the most important vegetables to maintain healthy DNA gene structure. Broccoli contains several active constituents, with sulforaphane being the most significant because of its unique detoxification and DNA-protecting effects. Life Extension Mix™ provides a concentrated broccoli mixture that provides standardized extracts of sulforaphane and glucosinolates, two compounds attributed to broccoli’s multiple protective benefits. Broccoli is also a natural source of gene-protecting
chlorophyll.44-51

D-glucarate is a botanical extract found in grapefruit, apples, oranges, broccoli, and brussels sprouts. D-glucarate effectively supports a detoxification process that helps to remove DNA toxins from the body.52-54 The daily dose of Life Extension Mix™ provides 200 mg of D-glucarate.

Lutein, an extract found in spinach and collard greens, has been shown to help maintain critical pigments in the eye macula,55 whereas lycopene from tomatoes has shown potent effects in helping to maintain DNA structure and protecting against LDL oxidation.56-58 Life Extension Mix™ contains 60 times more lutein and 10 times more lycopene compared to a leading conventional multivitamin tablet. Most multivitamin supplements provide no vegetable extracts whatsoever.

Standardized Fruit Extracts

In addition to standardized pomegranate and blueberry extracts, Life Extension Mix™ is also fortified with fruit extracts such as bilberry, grape seed, grape skin, and citrus bioflavonoids to protect against oxidative stress, provide healthy circulation throughout the body and maintain healthy DNA.

Scientists have long touted the multiple benefits of fruits such as blueberry, blackberry, cranberry, plums, elderberry, persimmon, and cherry. Life Extension Mix™ provides a customized blend of these and other fruits that studies indicate provide multiple favorable effects in the body.

Olive oil consumption is one of the important factors behind the health benefits of the Mediterranean diet.59,60 Researchers have discovered that there are up to 300 times more polyphenol compounds in olive water compared to olive oil.61 Olive polyphenols have been the subject of numerous in vitro, in vivo, and human studies pointing toward their benefits in many different areas, including protecting against LDL oxidation, suppressing free radicals, and stabilizing cell membranes.62-65 Life Extension Mix™ contains a potent olive extract standardized to provide the best-documented polyphenol, hydroxytyrosol.66 The amount of hydroxytyrosol in the daily dose of Life Extension Mix™ is equivalent to consuming more than one ounce of virgin olive oil a day.

Sesame Lignans Enhance the Effects of Vitamin E

Sesame and its lignans have a broad range of applications in human health. This includes increasing human tissue levels of vitamin E by facilitating carrier proteins in the liver to deliver nutrients to cells throughout the body.67,68

Sesame lignans increase the beneficial effects of fish oils, help regulate LDL oxidation, and help maintain already healthy cholesterol/LDL levels in those already within normal range.69-72

Life Extension Mix™ provides 10 mg of a sesame lignan extract to supply the direct benefits of the lignans, and augment the effects of vitamin E, gamma tocopherol and other nutrients in the body such as gamma linolenic acid.

Maintaining Already-Healthy Blood Glucose Levels

Chromium, along with magnesium and biotin, are nutrients required to maintain already normal blood sugar levels. Life Extension Mix™ provides 500 mcg of chromium, highly absorbable forms of magnesium, and a super high-potency biotin. A review of studies showing benefits of magnesium and chromium supplementation reveals that these higher doses are required for optimal effects.73-77

Higher Potency Vitamin D3

Doctors used to be concerned that too much vitamin D could be toxic. Over the past few years, however, an increasing body of evidence indicates that it takes much higher doses of vitamin D (perhaps over 10,000 IU/day) to inflict toxicity on a healthy person. Recent studies show that higher potencies are needed to combat the widespread vitamin D deficiency.78-79 However, that lingering fear of vitamin D toxicity is keeping many people from supplementing with enough vitamin D, which is critical for maintaining bone density, healthy cell division and immune health.80-84

In response to studies showing that even those who take standard vitamin D supplements are not obtaining adequate amounts, Life Extension Mix™ provides 2,000 IU of vitamin D3 per daily dose (most Life Extension members should take an additional 5,000 IU of vitamin D).

Pyridoxal 5’-Phosphate

Life Extension Mix™ also includes a form of vitamin B6 that helps block the formation of advanced glycation end products. Pyridoxal 5’-phosphate is the metabolically active B6 that has been shown to protect against protein and lipid glycation reactions.85-88 This latest version of Life Extension Mix™ provides 100 mg of pyridoxal 5’-phosphate in each daily dose.

The Most Complete Multi-Nutrient Formula

Life Extension Mix™ saves time and money by combining the most popular nutrient supplements into one product, eliminating the need to purchase separate bottles of B-complex, vitamins C and E, mineral supplements, and much more that would be required to achieve the same effects.

Life Extension Mix™ supplies the most powerful antioxidants, including water- and fat-soluble vitamin C, the ideal form of alpha vitamin E, and plant extracts that help protect against cellular DNA damage. Additional ingredients in Life Extension Mix™ enhance beneficial DNA methylation patterns, help maintain already normal glycemic control, and help regulate the oxidation of LDL.

Life Extension Mix™ is the keystone of a comprehensive supplement program because it provides so many well-studied nutrients. If you are on a budget, Life Extension Mix™ provides the best “cost-per-milligram” value.

The ingredients in the Life Extension Mix™ come only from top-quality suppliers. These premium companies charge more for their vitamins and trace elements, but the purity of these substances greatly exceeds that of the lower cost generic versions that are so prevalent in the vitamin industry.

For Members Who Want to Take Nutrients Separately

The most comprehensive multi-nutrient formula is Life Extension Mix™. Some Foundation members, however, prefer to take their nutrients separately and need only a basic multivitamin-mineral supplement to fill the missing gaps. For many years, these members had to rely on commercial “one-a-day” supplements that provide very low potencies.

In response to requests for a science-based multi-nutrient, the Two-Per-Day was formulated to provide the greatest potencies that can fit into two daily tablets. When compared to conventional “one-a-day” products, Life Extension Two-Per-Day contains up to 50 times more potency!

Multivitamin products are widely available. Regrettably, most people are unaware of the potencies of each nutrient needed to achieve optimal effects. Commercial companies take advantage of consumer ignorance by putting in such low potencies of certain nutrients that the user derives little or no benefit.

The box on this page reveals how much more potent a daily dose of the Two-Per-Day formula is compared to the leading commercial multivitamin. Few consumers realize that commercial supplements often contain the cheapest form of nutrients that don’t provide optimal benefits. For example, the 30 IU of synthetic vitamin E contained in Centrum® may provide relatively little vitamin E to the bloodstream. Studies show that synthetic vitamin E is distributed throughout the body only about half as much as natural vitamin E.89-94 The 200 IU of natural vitamin E contained in Two-Per-Day thus provides about 13 times more vitamin E activity than Centrum®.

The daily dose of Two-Per-Day formula was designed to remedy the widespread deficit of basic nutrients that exists even among multivitamin users. For example, Centrum® Silver users get only 400 IU of Vitamin D daily as compared to 2,000 IU in Two-Per-Day (five times the amount found in Centrum®). At the suggested dose of one tablet two times a day, health-conscious people are ensured they are obtaining potencies of nutrients that have demonstrated positive effects in published scientific studies for most of the nutrients.

Since most vitamins are water-soluble, which means they don’t last long in the body, it is best to consume these nutrients at least two times a day, ergo the Two-Per-Day formula’s design.

Each Life Extension Two-Per-Day Tablet is shaped in a moderate-sized caplet for ease of swallowing. To give you an idea of how potent this multi-nutrient supplement is, we compared two tablets of Two-Per-Day to one tablet of today’s best selling multivitamin (Centrum®) in the chart on this page.

A bottle of 120 Life Extension Two-Per-Day Tablets retails for $18.95. This represents a two-month supply at the suggested daily dose. If you are a member of the Life Extension Foundation®, you can reduce your monthly cost of the Two-Per-Day to only $6.38 when four bottles are purchased at the same time. When looking at the price of many commercial brands that only provide a fraction of the nutrients contained in the Two-Per-Day formula, you can quickly see how affordable it is to obtain the potencies of the most important basic nutrients.

Most members rely on Life Extension Mix™ with its broad-spectrum fruit and vegetable extracts, minerals, amino acids and vitamins. Those who consume these nutrients in other supplements can use Two-Per-Day Tablets to ensure they are not deficient in nutrients that were long ago established to be essential.

More Info on Multivitamins and Minerals

References

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60. Valavanidis A, Nisiotou C, Papageoriou Y, et al. Comparison of the radical scavenging potential of polar and lipidic fractions of olive oil and other vegetable oils under normal conditions and after thermal treatment. J Agric Food Chem. 2004 Apr 21;52(8):2358-65.

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62. Valavanidis A, Nisiotou C, Papageoriou Y, et al. Comparison of the radical scavenging potential of polar and lipidic fractions of olive oil and other vegetable oils under normal conditions and after thermal treatment. J Agric Food Chem. 2004 Apr 21;52(8):2358-65.

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67. Parker RS, Sontag TJ. Cytochrome P-450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J Biol Chem. 2002 Jul 12;277(28):25290-6.

68. Meier R, Tomizaki T, Schulze-Briese C, et al. The molecular basis of vitamin E retention: structure of human alpha-tocopherol transfer protein. J Mol Biol. 2003 Aug 15;331(3):725-34.

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