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Recommendation Number 2:

Super Omega-3 EPA/DHA with Sesame Lignans and Olive Fruit Extract

DOSAGE: 4 softgels per day.

Ingest Plenty of Omega 3 Fish Oil Supplements

The omega-3 fatty acids from cold-water fish have received an enormous amount of favorable publicity. One reason is that there have been more scientific studies to document fish oil’s multiple health benefits than perhaps any other nutrient.

Commercial fish oil comes in a wide range of purities and potencies. When evaluating the safety and potency offish oil, the following three factors should be considered:

  1. Stability: Fish oil can easily turn rancid, so a measurement of oxidative by-products is a critical step to ensure that the omega-3s you swallow are fresh.
  2. Purity: Cold-water ocean fish are rich in EPA/DHA, but are often contaminated with pollutants like PCBs, mercury, and arsenic. The fish oil you swallow should go through the purification processes needed to reduce contaminant levels to safe ranges.
  3. EPA-DHA consistency: The primary active ingredients in fish are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Assaying fish oil to make sure it meets label claim is important to ensuring you are ingesting the desired amounts of EPA/DHA.

In order to protect consumers against unsafe and ineffective products, the Council for Responsible Nutrition has proposed strict guidelines for all fish oil products marketed in North America. The good news is that a fish oil concentrate is available today that exceeds these proposed, upgraded standards and stringent international standards.

Supportive but not conclusive evidence shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease.

The Gold Standard Fish Oil Extract

Super Omega-3 EPA/DHA with Sesame Lignans & Olive Fruit Extract is a fish oil concentrate that uses a patented extraction and purification process to improve stability, reduce contaminants to virtually undetectable levels, and to protect against oxidation and peroxidation of the delicate omega-3 fatty acids.

To obtain a fish oil this clean and stable, a patented method was developed to purify the oil with an intense distillation process. The result is cleaner fish oil that has shorter heat exposure and prevents thermal (heat) degradation of the EPA/DHA. The result is an improved fish oil that exceeds the standards set by international rating agencies. Super Omega-3 is certified to contain no detectable levels of mercury, arsenic, lead, cadmium, and other toxic metals by the International Fish Oil Standards (IFOS™). This product meets or exceeds IFOS standards for PCBs, dioxins, and other contaminants, and thus has received its highest 5-star rating.

These patented distillation processes remove other impurities that lead to reflux, burping, and regurgitation in some people. The Super Omega-3 EPA/DHA also smells better by virtue of these processes and is more tolerable to people with sensitive stomachs.

What Makes Super Omega-3 EPA DHA the Best Of All Fish Oil Supplements?

What Makes Super Omega-3 the Best Fish Oil Supplement?
This chart shows that GLA can follow a pro-inflammatory or anti-inflammatory pathway in the body. Sesame lignans suppress the enzyme (delta-5 desaturase) that converts DGLA into arachidonic acid. By blocking the undesirable enzyme (delta-5 desaturase), more DGLA is available for conversion into beneficial prostaglandin E1.

Super Omega-3 fish oil concentrate provides a full spectrum blend of fatty acids and synergistic nutrients to provide optimal effects in the body.

The addition of sesame lignans to fish oil enhances its beneficial effects.1 When fats are consumed, they are broken down into compounds that either promote or suppress inflammatory reactions. Specialized enzymes in the body determine which inflammatory pathway fats will follow.

Sesame lignans inhibit a dangerous enzyme (delta-5 desaturase) that causes DGLA (dihomo-gamma linolenic acid) to be converted into arachidonic acid, a precursor to the toxic inflammatory factors prostaglandin E2 and the leukotrienes.2 (Refer to the chart to the right for a clearer understanding of these metabolic pathways).

Extending the Stability of Fish Oil in the Body

Sesame also functions as a powerful antioxidant, and its addition to fish oil lowers undesirable lipid peroxidation rates.3,4 Sesame suppresses the formation of free radicals from the DHA fraction of fish oil, which has extremely high oxidative susceptibility.5 A test of this effect was confirmed in rats fed a high DHA diet from fish oil. In the first part of the study, DHA alone lowered vitamin E levels and raised a measure of free radical damage. The addition of sesame raised plasma and liver vitamin E levels higher, increased concentrations of DHA, and completely suppressed free radical production from the DHA in tissues and serum.3

The combination of sesame and fish oil (as found in the Super Omega-3 formula) thus helps to suppress free radical production of fish oil by blocking lipid peroxidation and simultaneously boosting levels of beneficial fatty acids (such as DGLA and DHA).6,7

Increased Burning of Blood Lipids

In order for cells to produce energy, they must burn fatty acids in their mitochondria. The failure of liver mitochondria to properly burn fatty acids can result in excess accumulation of triglycerides. Triglycerides not burned in the liver accumulate in the blood and contribute to arterial occlusion and unwanted weight gain.

In two animal studies, combining sesame lignans and fish oil caused hepatic fatty acid oxidation rates to rise much higher than fish oil alone.8,9 This shows that the synergistic combination of fish oil and sesame improves mitochondrial fatty acid energy utilization to facilitate triglyceride reduction and guard against the free radicals generated as an inevitable consequence of higher cellular metabolism.3,4,8,9

The Virtues of Olive Fruit Polyphenols

Published studies show that hydroxytyrosol scavenges the dangerous free radical hydrogen peroxideand reduces LDL susceptibility to oxidation.10 The oxidation of LDL plays a significant role in the development of vascular impairment.

According to two studies, as the polyphenol content of olive oil increases, there is an increase inglutathione antioxidant activity anda decrease inthe oxidation of LDL.11,12 These effects are associated with improved cardiovascular health.

Additional Protection Against Platelet Aggregation

When blood platelets that guard against excessive bleeding become overactivated, they can form clots inside arteries leading to acute circulatory disruptions. Fish oil’s EPA/DHA help protect against excess platelet aggregation.

An olive fruit polyphenol called oleuropein has also been shown to reduce blood platelet activity in humans,13 thus providing yet another explanation as to why those who consume a Mediterranean diet have such low rates of sudden vascular events.

Oleuropein from the olive fruit also has additional biological properties. When administered to human fibroblast skin cells cultures, oleuropein delayed the appearance of senescent (aging) structural changes and increased the lifespan of these cells by approximately 15%.14

In addition, oleuropein has been proven effective in down-regulating HER2 expression.15 These findings help explain why those who consume a Mediterranean diet have such marked reductions in problems related to excess expression of the HER2 gene, which is part of a family of genes that plays a role in regulating cell growth.

Now Super Omega-3 not only contains the finest omega-3 fish oil blend in the world, but also provides an even more potent olive fruit blend (equivalent to the polyphenol value of 6 ounces of extra virgin olive oil) standardized for hydroxytyrosol, tyrosol and oleuropein polyphenols.

Premium Quality at an Affordable Price

Despite the costly processes involved in making this superior fish oil concentrate, the low price of Super Omega-3 EPA/DHA with Sesame Lignans & Olive Fruit Extract enables consumers to obtain the broad-spectrum benefits of this omega-3 supplement along with additional beneficial nutrients.

A bottle containing 120 softgels of Super EPA/DHA with Sesame Lignans & Olive Fruit Extract retails for $32.00. If you are a member of the Life Extension Foundation®, you can reduce your cost to only $21.00 each when four bottles are purchased at the same time.

For those with a sensitive stomach, Super Omega-3 is now also available with enteric coating and retails for $34. If a member buys four bottles, that cost is reduced to just $23.25 a bottle.

IFOS™ certification mark is a trademark of Nutrasource Diagnostics, Inc. These products have been tested to the quality and purity standards of the IFOS™ program conducted at Nutrasource Diagnostics, Inc.

Important note: If you are taking anticoagulant drugs, use this product only under the supervision of your physician. Blood tests that measure clotting can be used to ensure these nutrients are not reducing the clotting factors in your blood to abnormal levels.

More Info on Omega 3 Fish Oil Supplements

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Omega 3, Fish Oil, Fatty Acids
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EPA and DHA omega-3 fatty acids
Top Ten Nutritional Supplements
1: Multivitamins and Minerals
(Life Extension Mix™)
2: Omega-3 Fatty Acids (Fish Oil)
3: Coenzyme Q10 (CoQ10)
4: Mitochondrial Function (MEO)
5: Hormone Balance (DHEA)
6: Brain Cell Function (Cognitex)
7: Bone Health (for women and men)
7a: Prostate Health (for men only)
8: Neural and Hepatic Health (SAMe)
9: Cardiovascular Health (Aspirin)
10: Vitamin K, Gamma Tocopherol (Super Booster Softgels)

References

1. Ide, T, Hong, DD, Ranasinghe, P, et al. Interaction of dietary fat types and sesamin on hepatic fatty acid oxidation in rats. Biochem Biophys Acta. 2004 Jun 1;1682(1-3):80-91.

2. Utsunomiya, T, Chavali, SR, Zhong, WW, et al. Effects of sesamin supplemented dietary fat emulsions on the production of lipopolysaccharide-induced prostanoids and tumor necrosis factor alpha in rats.Am J Clin Nutr. 2000 Sep;72(3):804-8.

3. Ikeda S, Kagaya M, Kobayashi K, et al. Dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid. J Nutr Sci Vitaminol. (Tokyo). 2003 Aug;49(4):270-6.

4. Kang MH, Katsuzaki H, Osawa T. Inhibition of 2,2’-azobis(2,4-dimethylvaleronitrile)-induced lipid peroxidation by sesaminols. Lipids. 1998 Oct;33(10):1031-6.

5.Yamashita K, Kagaya M, Higuti N, et al. Sesamin and alpha-tocopherol synergistically suppress lipid-peroxide in rats fed a high docosahexaenoic acid diet. Biofactors. 2000;11(1-2):11-3.

6. Chavali SR, Zhong WW, Forse RA. Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of delta-5-desaturation of omega6 and omega3 fatty acids in mice. Prostaglandins Leukot Essent Fatty Acids. 1998 Mar;58(3):185-91.

7. Akimoto K, Kitagawa Y, Akamatsu T, et al. Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents. Ann Nutr Metab. 1993;37(4):218-24.

8. Ashakumary L, Rouyer I, Takahashi Y, et al. Sesamin, a sesame lignan is a potent inducer of hepatic fatty acid oxidation in the rat. Metabolism. 1999 Oct;48(10):1303-13.

9. Arachchige PG, Takahashi Y, Ide T. Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats. Metabolism. 2006 Mar;55(3):381-90.

10. Rietjens SJ, Bast A, Haenen GR. New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol. J Agric Food Chem. 2007 Sep 5;55(18):7609-14.

11. Weinbrenner T, Fito M, de la Torre R, et al. Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men. J Nutr. 2004 Sep;134(9):2314-21.

12. Gimeno E, Fito M, Lamuela-Raventos RM, et al. Effect of ingestion of virgin olive oil on human low-density lipoprotein composition. Eur J Clin Nutr. 2002 Feb;56(2):114-20.

13. Singh I, Mok M, Christensen AM, et al. The effects of polyphenols in olive leaves on platelet function. Nutr Metab Cardiovasc Dis. 2008 Feb;18(2):127-32.

14. Katsiki M, Chondrogianni N, Chinou I, et al. The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts.Rejuvenation Res. 2007 Jun;10(2):157-72.

15. Menendez JA, Vazquez-Martin A, Colomer R, et al. Olive oil’s bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. BMC Cancer. 2007 May 9;7:80.
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