Recommendation Number 10

Super Booster Softgels with Advanced K2 Complex

DOSAGE: 1 softgel per day with a meal.

Filling in the Missing Gaps

In spite of all the scientific validation surrounding the health benefits of various nutrients, many people fail to include them in their daily supplement regimen because they do not want to take so many individual pills. This problem has been solved with Life Extension®’s Super Booster, a softgel that includes a multitude of health-promoting nutrients with the convenience of one-per-day dosing. Super Booster contains nutrients that are difficult to fit into dry-based formulas like the Life Extension Mix™ formula (Recommendation #1 of the Top Ten Steps to Optimal Health).

Included in this potent, multi-nutrient formula are the most biologically active forms of vitamin K2 [known as menaquinone-4 (MK-4) and menaquinone-7 (MK-7)]. Human studies show that vitamin K2 is absorbed up to ten times more effectively than K1.1 Vitamin K2 also remains biologically active in the body far longer than K1. For instance, K1 is rapidly cleared by the liver within 8 hours, whereas measurable levels of K2 (as MK-7) have been detected 72 hours after ingestion. Because it is not metabolized quickly by the liver, only small amounts of vitamin K2 are needed to maintain optimal gamma-carboxylation status of
Gla-proteins such as osteocalcin (in bone) and matrix-Gla protein (in the arterial vessel wall). These proteins direct calcium into the bones and prevent calcium precipitation in the arterial wall.2

Super Booster provides higher doses of menaquinone-7 in addition to vitamin K1 and MK-4.

Super Booster functions as the perfect complementary supplement because it contains nutrients that cannot fit into the tightly packed dry powder formula, along with nutrients that only come in an oil-base, and therefore require a softgel cap to contain them. Super Booster also contains nutrients with health benefits so well-documented that people often want to take higher amounts than what is provided in their daily multivitamin.

Just one softgel of Super Booster Softgels provides critically important nutrients such as gamma-tocopherol that are lacking in most multi-nutrient formulas. Scientists have shown that people supplementing with the alpha-tocopherol form of vitamin E should also consume gamma-tocopherol. The reason is because alpha-tocopherol displaces gamma-tocopherol in the body, which may result in a lack of protection against certain types of free radicals.3,4

Augmenting the Effects of Gamma Tocopherol

One problem with gamma tocopherol is that the tissue has a high turnover rate, making it disappear relatively quickly.5 Super Booster provides 20 mg of sesame lignan extract which has been shown to increase levels of gamma tocopherol throughout the body.6

In human and animal studies, administration of sesame lignans increases tissue and serum levels of all vitamin E analogs, including gamma- and alpha-tocopherol.6,7  Of particular interest are animal studies showing that sesame lignans elevate gamma-tocopherol levels quite dramatically.8 This is critical because gamma-tocopherol, but not alpha-tocopherol, quenches reactive nitrogen species, such as the peroxynitrite radical, which we know plays a major role in the development of cardiovascular problems.8

The reason it is so difficult to raise gamma-tocopherol levels in human tissues and serum is due to two forces that are constantly at work to defeat it. The only carrier protein that transports vitamin E from the liver to the tissues, alpha-tocopherol carrier protein, is highly selective in transporting alpha-tocopherol in a 11-to-1 ratio to gamma-tocopherol.10

This means relatively little gamma-tocopherol ends up in the cell membranes compared to alpha-tocopherol. Studies have shown that adding sesame to a rat diet increased vitamin E alpha-serum levels 40%, and gamma-tocopherol levels up to about 500%,4 while lowering a measurement of free radical-induced damage (thiobarbituric reactive substances) by 82.8%.11 A human study showed a single dose of sesame oil, containing 136 mg sesame lignans (sesamin and sesamolin), reduces the urinary excretion of co-administered gamma-tocopherol in humans.12

Because of the importance of obtaining the gamma fractions of vitamin E, most Life Extension members who take the Two-Per-Day Tablets or Life Extension Mix™ (see Recommendation #1), also take one capsule of Super Booster Softgels.

So Much Potency in Just One Softgel

In order to reduce the cost and inconvenience of taking many different pills, Super Booster Softgels provide optimal doses of ginkgo extract, vitamin K1 and K2, chlorophyllin, lycopene, three forms of selenium, and other nutrients in just one capsule.

Ginkgo is a popular supplement because of its multi-faceted effects of promoting healthy circulatory and neurological function.13

Vitamin K helps direct calcium to bones, while helping to maintain healthy arterial structure and elasticity.14 Chlorophyllin is a nutrient used as protection against DNA gene mutation.15

The effects of selenium in boosting glutathione and protecting healthy cell colonies are well-established.16 Most people don’t know that the scientific literature reveals that there are several different forms of selenium that provide the diverse biological benefits attributed to this mineral. Super Booster provides selenomethionine, sodium selenate, and Se-methylselenocysteine.

Lycopene continues to impress scientists as the red carotenoid that inhibits LDL oxidation and also protects DNA gene integrity.17-19

Save Money with the Multi-Ingredient Super Booster!

Super Booster Softgels saves you money by combining multiple ingredients into one formula. Listed on the previous page are the ingredients contained in just one softgel of this advanced multinutrient formula.

The cost of purchasing these ingredients individually greatly exceeds the price of Super Booster Softgels. For instance, the retail prices of the gamma E tocopherol, lycopene-lutein extracts, vitamin K, ginkgo extract, and chlorophyllin add up to over $100. By using Super Booster, members can save over 70% of the cost of buying these ingredients separately. The retail price for a bottle of 60 softgels is $42.00. If a Life Extension member buys four bottles, the price is reduced to only $28.50 per bottle.

Since most of these ingredients are fat-soluble, Super Booster Softgels should be taken with the heaviest meal of the day. Because the largest meal of the day often contains the most dietary mutagens, it is appropriate to consume the chlorophyllin contained in Super Booster at this time.

Caution: If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.

More Info on Super Booster Softgels with Advanced K2 Complex

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References

1. Haemostasis. 2000 Nov-Dec;30(6):298-307.

2. Z Kardiol. 2001;90 Suppl 3:57-63.

3. Nutr Rev. 2006 Jun;64(6):295-9.

4. Am J Clin Nutr. 2001 Dec;74(6):714-22.

5. Lipids. 1992 Jan;27(1):38-41.

6. Am J Clin Nutr. 2008 Jun;87(6):1723-9.

7. Lipids. 2002 Apr;37(4):351-8.

8. J Nutr. 2002 May;132(5):961-6.

9. Med Hypotheses. 2007;69(6):1367-70.

10. FEBS Lett. 1997 Jun 2;409(1):105-8.

11. Life Sci. 2000 66(2):161-71.

12. Ann N Y Acad Sci. 2004 Dec;1031:365-7.

13. Altern Med Rev. 1998 Feb;3(1):54-7.

14. Eur J Nutr. 2004 Dec;43(6):325-35.

15. Methods Mol Biol. 2004;274:159-71.

16. Altern Med Rev. 2004 Sep;9(3):239-58.

17. Clin Sci. 2003 Sep;105(3):355-61.

18. Antioxid Redox Signal. 2000 Fall;2(3):491-506.

19. Toxicol In Vitro. 2007 Aug;21(5):840-5.

Top Ten Item
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Top Ten Recommendation
Top Ten Nutritional Supplements
1: Multivitamins and Minerals (Life Extension Mix™)
2: Omega-3 Fatty Acids (Fish Oil)
3: Coenzyme Q10 (CoQ10)
4: Mitochondrial Function (MEO)
5: Hormone Balance (DHEA)
6: Brain Cell Function (Cognitex)
7: Bone Health (for women and men)
7A: Prostate Health (for men only)
8: Neural and Hepatic Health (SAMe)
9: Vitamin D Levels (Vitamin D3)
10: Vitamin K, Gamma Tocopherol (Super Booster Softgels)

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