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Alpha lipoic acid consists of two different forms (isomers) that have vastly different properties. The “R” form is the biologically active component (native to the body) that is responsible for lipoic acid’s phenomenal antioxidant effect. The “S” form is produced from chemical manufacture and is not very biologically active. Alpha lipoic acid supplements consist of the “R” and “S” form in a 50/50 ratio. That means a 100 mg alpha lipoic acid supplement is providing 50 mg of the biologically active “R” form.
The human body normally produces and uses R-lipoic acid, the active form. R-lipoic acid significantly reduces inflammatory reactions and has been shown to be more potent than the combined “R” and “S” form that comprise alpha lipoic acid.31-40*
When alpha lipoic acid is ingested, it is first converted to its reduced form, R-dihydro-lipoic acid, where the main action of lipoic acid is initiated. R-dihydro-lipoic acid is the reduced (or active) form of R-lipoic acid. R-dihydro-lipoic acid produces the majority of the results attributed to R-lipoic acid and alpha lipoic acid. By consuming R-dihydro-lipoic acid, you are obtaining the form of R-lipoic acid that is immediately available to cells. R-dihydro-lipoic acid is only available in liquid softgels because it is itself a liquid and must be kept sealed from air.
For members who have been using Super Alpha Lipoic Acid capsules, Life Extension’s “R”-Dihydro-Lipoic Acid softgels provides a more effective form of lipoic acid. Each softgel of “R”-Dihydro-Lipoic Acid supplement contains 150 mg of this lipoic acid form that provides greater biological activity compared to a 300 mg capsule of regular alpha lipoic acid.
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If you have diabetes or hypoglycemia, please consult your healthcare practitioner before supplementing with lipoic acid.
Diabetes, Blood Sugar, Antioxidant