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Life Extension Track Record

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An Impeccable Track Record of 34 Years of Scientific Achievements in Health and Longevity

2000–2003: Antioxidants, Stem Cells, Alzheimer's Disease

  • In 2000, Life Extension revealed how COX-2 inhibiting drugs could increase pro-inflammatory factors in the body, potentially leading to permanent joint damage and vascular disease. In 2004, one of these drugs (like Vioxx®) was taken off the market because of increased risks of heart attack in those who took it. For the COX-2 inhibiting drugs (like Celebrex®) that remain on the market, black-box warnings are now placed on their label cautioning about increased heart attack risk when using these drugs.

  • In 2000, Life Extension unveiled a European therapy (polyenylphosphatidylcholine) that may protect against fatty liver disease and Hepatitis C, alleviate pancreatitis and ease drug-induced gastric toxicity.

  • In 2000, Life Extension sponsored a bill that was passed and signed into law that enabled Americans to obtain lower-cost prescription drugs from other countries. (This bill was later sabotaged by the FDA.)

  • In 2000, Life Extension introduced a combination therapy used in Europe to boost cognitive function and that may alleviate the symptoms of senility.

  • In 2000, Life Extension conducted original research using carotid ultrasound tests to show that people taking high doses of antioxidants over an extended period of time may be protected against atherosclerosis.

  • In 2000, Life Extension introduced members to revolutionary research to transform cloned stem cells into tissues to replace diseased ones.

  • In 2001, Life Extension introduced high-dose carnosine to prevent the formation of advanced glycation end-products, a key molecular mechanism linked to premature aging and diabetic complications.

  • In 2001, Life Extension funded research to identify genes linked to aging, versus those that act to extend life. This research has led to the discovery of agents that mimic the longevity-promoting effects of calorie restriction.

  • In 2001, Life Extension published methods of suppressing pro-inflammatory cytokines that contribute to the development of multiple degenerative diseases.

  • In 2001, Life Extension recommended a drug to treat Alzheimer's disease and Parkinson’s disease called memantine that had been used in Germany since 1991, but was not FDA approved. The FDA approved memantine 2.5 years later.

  • In 2002, Life Extension documented that a large number of Americans are needlessly dying of anemia and provided definitive methods to guard against this disorder.

  • In 2002, Life Extension showed that doctors are overlooking thyroid hormone deficiency because of the improper interpretation of a common blood test.

  • In 2002, Life Extension introduced methylselenocysteine, the form of selenium found naturally in garlic and broccoli that protects against mammary tumor development.

  • In 2003, Life Extension advised members to stock up on an anti-viral drug called Tamiflu® in case they were exposed to the common flu virus. Two years late, the world became so frightened about a potential SARS virus pandemic that Tamiflu® disappeared from pharmacy shelves worldwide. Foundation members who heeded Life Extension’s early warning already had their personal supply of Tamiflu® in their medicine cabinet.

  • In 2003, Life Extension introduced the first therapeutic program to slow the progression of Parkinson’s disease.

  • In 2003, Life Extension published research showing that topical and orally ingested antioxidants can prevent and reverse skin aging.

  • In 2003, Life Extension revealed an effective strategy for reducing the frequency and intensity of debilitating migraine headaches by restoring hormone balance.

  • In 2003, Life Extension warned that eating foods cooked at high temperatures (over 250 degrees Fahrenheit) promoted weight gain and damaged the body’s proteins in a way that accelerated the aging process.

  • In 2003, Life Extension discovered that the drug metformin could mimic many of the beneficial effects of calorie restriction. The findings from Life Extension’s study were published in the Proceedings of the National Academy of Sciences.

  • In 2003, Life Extension introduced a plant extract to protect against DNA mutations and neutralize carcinogens.

2004–2006: Osteoporosis, Fish Oil Supplements, Diabetes

  • In 2004, Life Extension warned of the hidden dangers of osteoporosis in men.

  • In 2004, Life Extension introduced a novel fiber that reduces after-meal insulin release and limits carbohydrate absorption.

  • In 2004, Life Extension reported that optimal glucose levels should be lower than current guidelines to reduce heart attack risk by 40%. Soon after, national standards for the upper-scale limit of blood glucose were lowered, but still not to the lower levels recommended by Life Extension.

  • In 2005, Life Extension conducted a clinical study showing that sesame lignans significantly enhance the antioxidant and anti-inflammatory effects of gamma tocopherol. Furthermore, Life Extension reported that standardized sesame seed lignans increase vitamin E activity and enhance the benefits of borage and fish oil supplements.

  • In 2005, Life Extension announced the startling finding that PSA (prostate-specific antigen) itself could promote prostate cancer and provided novel methods to lower PSA levels in aging men.

  • In 2005, Life Extension revealed how olive fruit polyphenols could boost beneficial HDL.

  • In 2005, Life Extension conducted a clinical study showing that an orally ingested agent could naturally increase superoxide dismutase (SOD) and catalase in the body. SOD and catalase are naturally produced antioxidants that are more potent than orally ingested antioxidants.

  • In 2005, Life Extension reported on a powerful phytochemical that suppresses the growth of prostate cancer cells. Derived from milk thistle extract, this novel compound, isosilybin B, may also protect the prostate gland by reducing the secretion of PSA.

  • In 2005, The National Academy of Sciences released a report confirming Life Extension’s position that X-rays at any dose pose health risks to humans.

  • In 2005, Life Extension alerted the public to the disease-causing toxins present in fish, and provided a strategy for safely capturing the health-promoting benefits of fish oil.

  • In 2005, Life Extension reported the startling news that conventional sunscreens may not prevent skin cancer and revealed how you can help protect yourself against skin cancer using topical antioxidants.

  • In 2005, Life Extension uncovered data showing that blueberry extract can help reverse the memory and motor impairments associated with aging.

  • In 2005, Life Extension revealed an effective strategy for reducing the frequency and intensity of debilitating migraine headaches using an herbal extract from Europe, and for restoring youthful hormones balance.

  • In 2006, Life Extension introduced a novel method of capturing the health-promoting benefits of caloric restriction without hunger.

  • In 2006, Life Extension revealed a new method for lowering homocysteine levels that fail to respond to standard nutritional therapies.

  • In 2006, Life Extension set forth a comprehensive strategy for guarding against metabolic syndrome, a deadly, often-overlooked condition that drastically increases the risk of heart attack, stroke and diabetes.

  • In 2006, Life Extension revealed why vegetarians do not live that much longer than meat-eaters and how easy it is to correct this problem by supplementing with one critical nutrient (carnosine).

  • In 2006, Life Extension exposed how drug companies are seeking to shut down compounding pharmacies that offer Americans access to safer and less expensive drugs.

  • In 2006, Life Extension warned readers about an FDA-approved fish oil drug that is priced 797% higher than what consumers pay for the same amount of EPA/DHA in supplement form.

  • In 2006, Life Extension showed how a novel form of vitamin K could guard against arterial calcification and osteoporosis.

  • In 2006, Life Extension presented a summary of cumulative findings showing how the proper intake of a plant extract could reverse atherosclerosis and slow the progression of prostate cancer.

  • In 2006, Life Extension identified how one missing plant extract was responsible for the epidemic of macular degeneration afflicting aging humans.

  • In 2006, Life Extension introduced a form of coenzyme Q10 (ubiquinol) that is vastly superior to commercial CoQ10 supplements in absorbing into the human bloodstream, reducing fatigue and slowing age-related markers.

  • In 2006, Life Extension published findings about how cruciferous vegetable extracts may prevent certain human cancers.

  • In 2006, Life Extension uncovered findings to show that new stem cell formation can be promoted in the body by ingesting commonly available nutrients.

  • In 2006, Life Extension exposed how the American FDA was attempting to censor truthful information about the health benefits of fruits and vegetables.

Continued on Page 3 of 4

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