- In 2013, Life Extension introduced the first enzyme formulation that facilitates digestion of dietary protein, fiber, and fat — without promoting the breakdown of starches and the rapid absorption of glucose into the bloodstream that triggers postprandial glucose surges.
- In 2013, Life Extension researchers analyzed 12 independent studies that evaluated blood glucose levels and breast cancer risk and found that 9 of the studies revealed a correlation between higher fasting glucose, or other indicators of poor glycemic control, and increased risk of cancer.
- In 2013, to enhance the body’s absorption of astaxanthin, Life Extension formulated this antioxidant carotenoid with phospholipids, clinically shown to boost astaxanthin absorption several-fold.
- In 2013, Life Extension introduced a formula utilizing the digestive enzyme transglucosidase, which is scientifically shown to transform starches into prebiotic fiber in the digestive tract, helping to support healthy glucose and insulin levels.
- In 2013, Life Extension published the updated, 5th edition of its Disease Prevention and Treatment book, containing more than 1,400 pages of innovative approaches to 130 common health concerns.
- In 2013, to support both cognitive and circulatory function as well as the brain’s normal defenses and regenerative mechanisms, Life Extension formulated a series of supplements containing the polyphenol gastrodin, an innovative compound that acts as a broad-spectrum “brain shield,” calming brain cells and protecting them from oxidant, inflammatory, and excitatory damage.
- In 2013, Life Extension formulated a supplement containing extracts of mung bean seed coat and EGCG (the major beneficial component in green tea), both powerful inhibitors of HMGB-1, the molecule that induces chronic inflammation, a chief accelerator of aging.
- In 2013, Life Extension created a broad-spectrum glucose control supplement featuring white mulberry leaf extract, sorghum extract, and phloridzin, three natural ingredients which work on numerous key mechanisms to improve insulin sensitivity, reduce blood glucose levels, safely transport glucose out of the body, and reduce the creation of new glucose in the liver.
- In 2013, Life Extension introduced a supplement containing omega-7 (palmitoleic acid), which has been shown to exert beneficial effects on many pathological components of metabolic syndrome. In addition to improving insulin sensitivity, lowering LDL-cholesterol-triglycerides, raising beneficial HDL, and helping to manage body weight, omega-7, most importantly, inhibits inflammation.
- In 2013, The Supplement Pyramid: How to Build Your Personalized Nutrition Program, written by Dr. Michael A. Smith, senior health scientist for Life Extension, was published, offering an easy-to-follow method for tailoring supplement use to one’s particular health goals and needs.
- In 2013, in an unprecedented breakthrough, Life Extension published the first protocol validated to extend median survival in glioblastoma (brain tumor) patients to 4.7 years, whereas conventional therapies only provide survival time of 12-15 months.
- In 2014, Life Extension identified a cause (leukoaraiosis) of cognitive decline that affects 60% of people late middle aged and older and developed protocols to slow its progress or prevent it entirely.
- In 2014, Life Extension published a meticulous rebuttal to a flawed study that claimed that testosterone replacement increased risk of death from cardiovascular disease in men.
- In 2014, to remind the public about the horrific persecutions endured by visionaries of the past, Life Extension published a historic account of innovations brutally suppressed by whatever “authority” existed at the time.
- In 2014, to fill a funding gap caused by federal budget cuts, Life Extension Foundation stepped in to support a record number of scientists developing therapies to slow aging and cure cancer.
- In 2014, Life Extension published a hypothesis by a world renowned expert that autism may be caused by a vitamin D deficit.
- In 2014, to suppress pro-inflammatory cytokines at the root of most age-related diseases, Life Extension identified a novel plant extract (mung bean seed coat).
- In 2014, zeroing in on an underlying cause of Alzheimer’s disease and stroke, Life Extension enlightened members to the brain damaging effects of “hypoperfusion” and identified validated methods to protect against it.
- In 2014, to further document the lethal impact of excess glucose, Life Extension published a compendium of published studies showing increased risks of cancer, atherosclerosis, dementia, obesity, and accelerated aging in response to modestly elevated blood sugar levels.
- In 2014, Life Extension revealed how comprehensive annual blood testing could spare hundreds of thousands of American lives each year.
- In 2014, Life Extension published an exclusive report on the European Congress on Biogerontology, where an international group of scientists presented cutting-edge research on longevity epigenetics, rejuvenation of the immune system, the dangers of CMV infection, and calorie restriction.
- In 2014, to expose a fatally flawed study published in the New England Journal of Medicine, Life Extension published a meticulous rebuttal showing the dangers of overdosing men on an estrogen-suppressing drug.
- In 2014, to spare the lives of newly diagnosed cancer patients, Life Extension provided strong data to persuade oncologists to prescribe immune boosting drugs before surgery, radiation and chemotherapy is administered.
- In 2014, an exclusive investigative report by Life Extension uncovered a generic drug rip-off where a topical cream (acyclovir) whose active ingredients cost 8 pennies was being sold to pharmacies for $600.
- In 2014, to warn women facing hysterectomies, Life Extension urged that a common surgical procedure (morcellation) be avoided.
- In 2014, Life Extension presented case histories of terminal cancer patients who have been cured or put into long-term remission utilizing innovative, individualized treatment protocols.
- In 2014, Life Extension revealed the importance of administering the proper form and dose of zinc lozenge to protect against the cold virus and outlined the 30-year journey that transpired before this zinc lozenge gained mainstream acceptance as a viable common cold treatment.
- In 2014, Life Extension presented a clinical study on the pharmacokinetics of ursolic acid at the prestigious Experimental Biology Conference, held in San Diego, California.
- In 2014, Life Extension introduced a supplement containing FBCx™ alpha-cyclodextrin, a patented super-fiber that absorbs fat molecules from food before they enter the bloodstream. This soluble fiber absorbs nine times its weight in dietary fat, without undesirable gastrointestinal side effects. Research shows that alpha-cyclodextrin selectively binds to unhealthy saturated and trans fats while maintaining healthy fats such as omega-3 fatty acids.
- In 2014, Life Extension expanded its probiotic line to introduce a novel strain for cardiovascular support. Lactobacillus reuteri (NCIMB 30242) has been shown in clinical trials to safely support healthy levels of cholesterol, CRP (a marker for inflammation), fibrinogen (involved in clot formation), apoB-100 (a marker for LDL particle size), and vitamin D (important for cardiovascular health).
- In 2014, the Life Extension Foundation sponsored a clinical study in which daily 7,000-IU doses of vitamin D improved several immunological parameters in HIV-positive children and young adults.
- In 2014, a study sponsored by the Life Extension Foundation showed that epigallocatechin-3-gallate, a green tea derivative, improved cognitive function in young adults with Down syndrome.
- In 2014, research funded by the Life Extension Foundation was published in the journal Nucleic Acids Research. This research, under Dr. Victoria Belancio, established that melatonin suppresses DNA (genome) instability, thereby protecting against cancer. The paper established that melatonin supplementation can be protective, and that shift-workers can be more vulnerable to DNA instability.
- Life Extension Foundation provided funding for a review article authored, primarily, by Drs. Vera Gorbunova and Andrei Seluanov in which the genetics of remarkable longevity and cancer resistance observed in some rodents was explored. The article was published as the cover story in the August 2014 issue of Nature Review: Genetics, the leading scientific journal on the subject of heredity and genetics.
- In 2014, Life Extension researchers developed an innovative, dual-mechanism formula designed to combat immune senescence. This formula is composed of two botanical compounds, Cistanche tubulosa extract and Reishi mushroom extract, that support adaptive (e.g., T cells and B cells) and innate (e.g., macrophages and neutrophils) immune response cells, respectively.
- In 2014, Life Extension created a specialized formula that supports adenosine monophosphate-activated protein kinase (AMPK) activation. Studies show increased AMPK activity helps reduce fat storage, promotes the production of new mitochondria, and helps keep blood glucose and lipids levels in a healthy range. In preclinical models, AMPK upregulation resulted in a 20-to-30% increase in life span.
- In 2014, Life Extension introduced a groundbreaking product featuring patented nicotinamide riboside (NR), which helps enhance cellular energy metabolism by increasing levels of the coenzyme nicotinamide adenine dinucleotide (NAD+). Studies show that, through the manipulation of multiple critical biochemical pathways, nicotinamide riboside has the potential to improve insulin sensitivity, confer neuroprotective effects, augment the benefits of exercise, and combat the detrimental effects of a high-fat diet.
- In 2014, a special “ionic” formula that contains zinc acetate, the preferred zinc compound to provide enhanced seasonal immune support, was launched by Life Extension. This product releases 100% of its zinc as positively charged zinc ions. Zinc acetate lozenges have been shown to strongly support immune function.
- In 2015, Life Extension formulated a supplement containing a specialized peptide complex derived from Saccharomyces cerevisiae, shown to reduce caloric intake and lessen abdominal fat accumulation. In a clinical trial, supplemented subjects reduced their daily caloric intake by 25.3% and lost nearly two full inches off of waist circumference, or about two belt sizes.
- In 2015, Life Extension introduced a formula providing concentrated pollen extracts specifically selected for effective prostate support, healthy urination patterns and prostate function. Two fractions in the flower pollen extracts, a water-soluble and a lipid-soluble fraction, support prostate health by helping maintain smooth muscle tone in the prostate, bladder, and urethra. For the first time, this European extract is available to Americans, providing a more potent dose in a convenient once-daily softgel.
- Life Extension Clinical Research, Inc. (LECR) completed two clinical trials presented as posters at the March 2015 Experimental Biology conference in Boston, MA. The first poster presented a case series on the effect of bisphosphonate medication use on CoQ10 blood levels, and the second poster described a study in which a lipid-based formulation containing 5,000 IU vitamin D3 raised vitamin D blood levels 29% over 60 days. From baseline to day 30, mean serum 25-hydroxyvitamin D levels increased by 7.34 ng/mL; by day 60, the increase had risen to 13.1 ng/mL. These results were statistically significant when compared to the use of a powder-based formulation.
- The Life Extension Foundation supported a study titled “Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans,” which was the result of collaboration with researchers from Barcelona, Spain. The study, which showed EGCG as a promising therapeutic tool for cognitive enhancement in Down Syndrome, was published in Molecular Nutrition and Food Research.
- The Life Extension Foundation supported a study titled “High-Dose Vitamin D3 Supplementation in Children and Young Adults with HIV: A Randomized, Placebo-Controlled Trial,” which was the result of a collaboration with a Children’s Hospital of Philadelphia researcher. The study, which found that 7,000 IU of vitamin D3 improved immunological parameters in HIV-positive individuals, was published in The Pediatric Infectious Disease Journal.
- The Life Extension Foundation co-funded research at the University of Liverpool to sequence the genome of the bowhead whale, a mammal whose nearly 200-year life span makes it the longest-living on earth. In findings published in the journal Cell Reports, the researchers discovered as many as 80 candidate genes related to DNA repair and cell proliferation that may help protect the whale from cancer or contribute to its inordinate longevity.
- In 2015, Life Extension highlighted the ancillary benefits of the angiotensin II receptor blocker medication telmisartan. Research has revealed that telmisartan, aside from effectively and safely lowering blood pressure, improves insulin sensitivity and endothelial function, enhances mitochondrial activity, and, in preclinical trials, helps control body weight.
- In 2015, Life Extension shed light on the lethal consequences of CoQ10 censorship by the FDA which has resulted in more American deaths than all the major wars combined. A recent study powerfully supported the use of CoQ10 for sufferers of congestive heart failure who combined the nutrient with standard therapy, achieving a 44% reduction in cardiovascular mortality compared to those receiving standard therapy alone.
- In May 2015, Life Extension described the dangers of elevated blood homocysteine, another risk factor for cardiovascular disease that has been linked to vascular dementia, diabetic complications, and increased risk of Alzheimer’s disease. A common genetic mutation (MTHFR C677T) contributes to elevated homocysteine in a substantial portion of the population. Supplementation with the active form of folate — 5-methyltetrahydrofolate — may normalize homocysteine levels in people with this genetic defect.
Membership in the non-profit Life Extension Foundation® is at an all-time high. Life Extension is growing because people are becoming aware that recommendations published by the Foundation in the early 1980s are now scientifically validated, and many are even accepted by the medical establishment.
The Life Extension Foundation® disseminates this practical life-saving information each month to its members in Life Extension Magazine®. Membership normally costs $75 a year, but members save far more than this on blood tests, compounded prescription drugs, state-of-the-art nutritional supplements, and free telephone access to knowledgeable Health Advisors.