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Apigenin Overview

Apigenin is described as a nonmutagenic bioflavonoid which is presented in leafy plants and vegetables (e.g., parsley, artichoke, basil, celery) and has significant chemopreventive activity against UV-radiation. Current research trials indicate that it may reduce DNA oxidative damage; inhibit the growth of human leukemia cells and induced these cells to differentiate; inhibit cancer cell signal transduction and induce apoptosis; act as an anti-inflammatory; and as an anti-spasmodic or spasmolytic.


Research Overview

1. TNF-induced transactivation was inhibited by apigenin.2. (BASIC RESEARCH)
2. The antiproliferative flavonoid apigenin led to an inhibition of protein kinase CK2 activity in prostate cell lines. (BASIC RESEARCH)
3. Apigenin is cytotoxic to a particular abnormal cell line in vitro. (BASIC RESEARCH)
4. Brined olives contain higher concentrations of phenolic antioxidants, including apigenin, than olive oil and may be more important modulators of cancer chemopreventive activity.
5. Apigenin may augments prostate cancer therapy. (BASIC RESEARCH)
6. Apigenin has strong potential for development as an agent for prevention against prostate cancer. (BASIC RESEARCH)
7. Apigenin is a pleiotropic effector affecting protease-dependent invasiveness and associated processes and proliferation of tumor cells. (BASIC RESEARCH)
8. Apigenin is a promising anti-breast cancer agent and its growth inhibitory effects. (BASIC RESEARCH)
9. Apigenin inhibits UV-induced skin tumorigenesis in mice when topically applied. (ANIMAL)
10. Apigenin markedly inhibited the proliferation, and, to a lesser degree, the migration of endothelial cells, and capillary formation in vitro. (BASIC RESEARCH)
11. Suppression of nuclear receptor levels is presented as a novel mechanism whereby flavonoids exert their pleiotropic effects. (BASIC RESEARCH)
12. Apigenin may provide a new approach for the treatment of human anaplastic thyroid carcinoma for which no effective therapy is presently available. (BASIC RESEARCH)
13. Modulation of COX-2 and iNOS by apigenin may be important in the prevention of carcinogenesis and inflammation. (BASIC RESEARCH)
14. Over 50% of tested flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin. (HUMAN)
15. Intervention with parsley, containing high levels of apigenin, seemed, partly, to overcome the decrease in antioxidant SOD. (HUMAN)
16. The flavones apigenin and luteolin strongly inhibited the growth of HL60 cells and induced morphological differentiation into granulocytes. (BASIC RESEARCH)
17. The wide distribution of isoflavonoids and flavonoids (including apigenin) in the plant kingdom, together with their anti-angiogenic and anti-mitotic properties, suggest that these phytoestrogens may contribute to the preventive effect of a plant-based diet on chronic diseases, including solid tumours. (BASIC RESEARCH)
18. Luteolin and apigenin inhibited E2-induced DNA synthesis. (BASIC RESEARCH)
19. In skin tumors, apigenin may block several points in the process of tumor promotion, including inhibiting kinases, reducing transcription factors and regulating cell cycle. (BASIC RESEARCH)
20. The effects of 21 synthetic and naturally occurring flavonoids on the in vitro growth of cells of the human breast carcinoma showed that apigenin was the most potent. (BASIC RESEARCH)
21. Flavonoids, including apigenin, may have a role in ameliorating atherosclerosis.
22. Flavonoids, including apigenin, prevent in vitro LDL oxidation and probably would be important to prevent atherosclerosis.
23. Flavonoids containing phenol B rings, included apigenin, formed prooxidant metabolites that oxidized NADH upon oxidation by peroxidase/H2O2.

Apigenin Abstracts (35)