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Calcium D-glucarate Overview

Calcium D-glucarate is the calcium salt of D-glucaric acid, a natural substance found in many fruits and vegetables. Calcium D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme found in certain bacteria that reside in the gut. One of the key ways in which the body eliminates toxic chemicals as well as hormones such as estrogen is by attaching glucuronic acid to them in the liver and then excreting this complex in the bile. Beta-glucuronidase is a bacterial enzyme that uncouples (breaks) the bond between the excreted compound and glucuronic acid. When beta-glucuronidase breaks the bond, the hormone or toxic chemical that is released is available to be reabsorbed into the body instead of being excreted. An elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers like breast, prostate, and colon cancers.

(Source: www.virtualhealthinfo.com)

Research Overview

Calcium D-glucarate shows the following effects:

1. Normalizes estrogen metabolism
2. Is involved with lipid lowering
3. Reduces risk of breast cancer
4. Reduces risk of colon cancer
5. Reduces risk of prostate cancer
6. Reduces risk of liver cancer
7. Inhibits metastases of tumors
8. Reduces serum cholesterol levels
9. Is non-toxic chemoprevention
10. Is non-toxic chemotherapy

Calcium D-glucarate Abstracts (35)