Cytidine diphosphate choline is the active form of choline normally
produced within the body. CDP choline is important for the synthesis of
phosphatidylcholine in cell membranes. Choline is a substance required
by the brain to produce acetylcholine, a major brain/motor neuron neurotransmitter
that facilitates the transmission of impulses between neurons. CDP-choline
stands for cytidine-5-diphosphocholine. This unique form of choline readily
passes through the blood-brain barrier (BBB) directly into the brain tissue.
Once past the BBB, CDP-choline activates the synthesis of critical components
in cell membranes and may enhance cerebral energy metabolism.
See Choline Overview
(Source: http://www.health-marketplace.com/CDP-Choline.htm)
Research Overview
The following studies showed that CDP Choline:
1. Affects brain phospholipids concentration
2. Improves verbal memory in aging.
3. May reverse age related changes in the brain.
4. May prevent age related cognitive decline that may be the precursor
of dementia.
5. Is a valid therapeutic remedy for the clinical, functional and social
recovery of geriatric patients.
6. Influences cognitive and cerebrovascular function in Alzheimer's
7. disease.
8. Diminished histamine (in Alzheimer's disease) and interleukin1 levels
in blood and serum, respectively, and increased plasma TNF.
9. Decreased brain damage following traumatic brain injury.
10. Exerts a neuroprotective effect by inhibiting the apoptotic pathway
induced by glutamate.
11. Provides choline for synthesis of neurotransmitter acetylcholine,
stimulation of tyrosine hydroxylase activity and dopamine release.
12. Treatment within the first 24 hours after onset in patients with moderate
to severe stroke increases the probability of complete recovery at 3 months.
13. Reduction in ischemic lesion volume growth from baseline to week 12
and a significantly greater reduction in volume from week 1 to week 12.
14. Appears to improve functional outcome and reduce neurologic deficit
with 500 mg appearing to be the optimal dose.
15. Provides significant neuroprotection during cerebral ischemia that
significantly reduces mortality.
16. In a doubleblind, placebocontrolled study, treatment of glaucoma resulted
in functional improvement in the visual system noted with electrophysiological
methods
17. Further research is being done on Parkinson’s disease and epilepsy.
CDP
Choline Abstracts (26)
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