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CDP Choline Overview

Cytidine diphosphate choline is the active form of choline normally produced within the body. CDP choline is important for the synthesis of phosphatidylcholine in cell membranes. Choline is a substance required by the brain to produce acetylcholine, a major brain/motor neuron neurotransmitter that facilitates the transmission of impulses between neurons. CDP-choline stands for cytidine-5-diphosphocholine. This unique form of choline readily passes through the blood-brain barrier (BBB) directly into the brain tissue. Once past the BBB, CDP-choline activates the synthesis of critical components in cell membranes and may enhance cerebral energy metabolism.
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Research Overview

The following studies showed that CDP Choline:
1. Affects brain phospholipids concentration
2. Improves verbal memory in aging.
3. May reverse age related changes in the brain.
4. May prevent age related cognitive decline that may be the precursor of dementia.
5. Is a valid therapeutic remedy for the clinical, functional and social recovery of geriatric patients.
6. Influences cognitive and cerebrovascular function in Alzheimer's
7. disease.
8. Diminished histamine (in Alzheimer's disease) and interleukin1 levels in blood and serum, respectively, and increased plasma TNF.
9. Decreased brain damage following traumatic brain injury.
10. Exerts a neuroprotective effect by inhibiting the apoptotic pathway induced by glutamate.
11. Provides choline for synthesis of neurotransmitter acetylcholine, stimulation of tyrosine hydroxylase activity and dopamine release.
12. Treatment within the first 24 hours after onset in patients with moderate to severe stroke increases the probability of complete recovery at 3 months.
13. Reduction in ischemic lesion volume growth from baseline to week 12 and a significantly greater reduction in volume from week 1 to week 12.
14. Appears to improve functional outcome and reduce neurologic deficit with 500 mg appearing to be the optimal dose.
15. Provides significant neuroprotection during cerebral ischemia that significantly reduces mortality.
16. In a doubleblind, placebocontrolled study, treatment of glaucoma resulted in functional improvement in the visual system noted with electrophysiological methods
17. Further research is being done on Parkinson’s disease and epilepsy.

CDP Choline Abstracts (26)