Alzheimer’s Disease References

Disease Prevention and Treatment, 5th edition

The references on this page correspond with the print version of Disease Prevention and Treatment, 5th edition. Since we continuously update the protocols online in response to new scientific developments, readers are encouraged to review the latest versions of the protocols.

  1. Upadhyaya P, Seth V, Ahmad M. “Therapy for Alzheimer’s disease: An update.” African Journal of Pharmacy and Pharmacology. 4.6 (2010): 408-21.
  2. Stern: Massachusetts General Hospital Comprehensive Clinical Psychiatry, 1st ed. Copyright © 2008 Mosby, An Imprint of Elsevier. Available at http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-0-323-04743-2..50021-4--cesec5&isbn=978-0-323-04743-2&uniqId=348489237-3#4-u1.0-B978-0-323-04743-2..50021-4--cesec5 Accessed 7/31/2012.
  3. Knopman DS. Alzheimer’s Disease and Other Dementias. In: Goldman L, Schafer AI. Goldman’s Cecil Medicine. 24th ed. Philadelphia, PA:Elsevier;2012. Available at: http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-1604-7..00409-7&isbn=978-1-4377-1604-7&uniqId=349213967-58#4-u1.0-B978-1-4377-1604-7..00409-7--s0010. Accessed August 3, 2012.
  4. Mayo Clinic. Alzheimer’s disease. Definition. Available at: http://www.mayoclinic.com/health/alzheimers-disease/DS00161/. Last updated January 18, 2011. Accessed August 2, 2012.
  5. Alzheimer’s Association. Risk Factors. 2012. Available at: http://www.alz.org/alzheimers_disease_causes_risk_factors.asp?gclid=CLyKuavN8bACFQeCnQoduQNh-Q. Accessed June 28, 2012b.
  6. Zhao Y, Zhao B. “Natural antioxidants in prevention and management of Alzheimer’s disease.” Front Biosci (Elite Ed). 1.4 (2012): 794-808.
  7. Tarawneh R, Holtzman DM. “The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment.” Cold Spring Harb Perspect Med. 2.5 (2012):a006148.
  8. Luan K, Rosales JL, Lee KY. “VIEWPOINT: Crosstalks Between Neurofibrillary Tangles and Amyloid Plaque Formation.” Ageing Res Rev. (2012) [Epub ahead of print]
  9. Teng CC, Yang YT, Chen YC, et al. “Role of WWOX/WOX1 in Alzheimer’s disease pathology and in cell death signaling.” Front Biosci (Elite Ed). 4 (2012): 1951-65.
  10. Rosales-Corral SA, et al. “Alzheimer’s Disease: Pathological Mechanisms and the Beneficial Role of Melatonin.” J Pineal Res. 52.2 (2012): 167-202.
  11. Wang X, Su B, Perry G, et al. Insights into amyloid-beta-induced mitochondrial dysfunction in Alzheimer disease. Free Radic Bio Med. 43.12 (2007): 1569-73.
  12. Fonte V, Dostal V, Roberts CM et al. A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo. Mol Neurodegener. 2011 Aug 23;6(1):61.
  13. Ittner LM and Götz J. Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci. 2011 Feb;12(2):65-72.
  14. Miklossy J. Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria. J Neuroinflammation. 2011 Aug 4;8:90.
  15. Vest RS, and Pike CJ. Gender, sex steroid hormones, and Alzheimer's disease. Horm Behav. 2012 Apr 19. [Epub ahead of print]
  16. Barron AM, Pike CJ. “Sex hormones, aging, and Alzheimer’s disease.” Front Biosci (Elite Ed). 2012 Jan 1;4:976-97.
  17. Baloyannis SJ, and Baloyannis IS. The vascular factor in Alzheimer's disease: A study in Golgi technique and electron microscopy. J Neurol Sci. 2012 Aug 2. [Epub ahead of print]
  18. Sadowsky CH, Galvin JE. “Guidelines for management of cognitive and behavioral problems in dementia.” J Am Board Fam Med. 25.3 (2012): 350-66.
  19. Alkadhi K and Eriksen J. The complex and multifactorial nature of Alzheimer's disease. Curr Neuropharmacol. 2011 Dec;9(4):586.
  20. Biasutti M, Dufour N, Ferroud C, et al. “Cost-Effectiveness of Magnetic Resonance Imaging with a New Contrast Agent for the Early Diagnosis of Alzheimer’s Disease.” PLoS One. 7.4 (2012): e35559.
  21. Massoud F, Gauthier S. Update on the pharmacological treatment of Alzheimer's disease. Curr Neuropharmacol. 2010 Mar;8(1):69-80.
  22. Marchesi VT. “Alzheimer’s disease 2012: the great amyloid gamble.” Am J Pathol. 180.5 (2012): 1762-7.
  23. Schmitz C, et al. “Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer’s Disease.” Am J Pathol. 2004 Apr;164(4):1495-502.
  24. Holmes C, et al. “Long-Term Effects of Abeta42 Immunisation in Alzheimer’s Disease: Follow-Up of a Randomised, Placebo-Controlled Phase I Trial.” Lancet. 2008 Jul 19;372(9634):216-23.
  25. Crespo-Biel N, Theunis C, and Van Leuven F. Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease. Int J Alzheimers Dis. 2012;2012:251426.
  26. Muñoz-Torrero D. Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease. Curr Med Chem. 2008;15(24):2433-55.
  27. Nieoullon A. [Acetylcholinesterase inhibitors in Alzheimer's disease: further comments on their mechanisms of action and therapeutic consequences]. Psychol Neuropsychiatr Vieil. 2010 Jun;8(2):123-31.
  28. Dong-gyu J, et al. “Evidence That γ-Secretase Mediates Oxidative-Stress Induced β-Secretase Expression in Alzheimer’s disease.” Neurobiol Aging. 2010 Jun;31(6):917-25.
  29. Hampel H, Prvulovic D, Teipel S, et al. The future of Alzheimer's disease: the next 10 years. Prog Neurobiol. 2011 Dec;95(4):718-28.
  30. Mandel S, et al. “Green Tea Catechins as Brain-Permeable, Natural Iron Chelators-Antioxidants for the Treatment of Neurodegenerative Disorders.” Mol Nutr Food Res. 50.2 (2006): 229-34.
  31. Salminen A, et al. “Inflammation in Alzheimer’s disease: Amyloid-β Oligomers Trigger Innate Immunity Defence via Pattern Recognition Receptors.” Prog Neurobiol. 87.3 (2009):181-194.
  32. Tobinick EL and Gross H. “Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer’s disease.” BMC Neurol. 8 (2008a): 27.
  33. Culpan d, Kehoe PG, Love S. “Tumor necrosis factor-α (TNF-α) and miRNA expression in frontal and temporal neocortex in Alzheimer’s disease and the effect of TNFα on miRNA expression in vitro.” Int J Mol Epidemiol Genet. 2.2 (2011): 156-62.
  34. Ardebili SM, Yeghaneh T, Gharesouran J, et al. Genetic association of TNF-α-308 G/A and -863 C/A polymorphisms with late onset Alzheimer’s disease in Azeri Turk population of Iran.” J Res Med Sci. 16.8 (2011): 1006-1013.
  35. Chen HK, Ji ZS, Dodson SE, et al. “Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease.” J Biol Chem. 2011 Feb 18;286(7):5215-21.
  36. Caselli RJ, Reiman EM. “Characterizing the Preclinical Stages of Alzheimer’s Disease and the Prospect of Presymptomatic Intervention.” J Alzheimers Dis. (2012) [Epub ahead of print]
  37. Polvikoski T, Sulkava R, Haltia M, et al. Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein. N Engl J Med. 1995 Nov 9;333(19):1242-7.
  38. Leuner K, Müller WE, and Reichert AS. From Mitochondrial Dysfunction to Amyloid Beta Formation: Novel Insights into the Pathogenesis of Alzheimer's Disease. Mol Neurobiol. 2012 Jul 26. [Epub ahead of print]
  39. Danysz W, Parsons CG. “Alzheimer′s disease, β-amyloid, glutamate, NMDA receptors and memantine – searching for the connections.” Br J Pharmacol. 2012 May 30. doi: 10.1111/j.1476-5381.2012.02057.x. [Epub ahead of print]
  40. Overk CR, Perez SE, Ma C, et al. Sex Steroid Levels and Ad-Like Pathology in 3xtgad Mice. [In Eng] J Neuroendocrinol. 2012 Aug 13;
  41. Soscia SJ, Kirby JE, Washicosky KJ, et al. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. PLoS One. 2010 Mar 3;5(3):e9505.
  42. Honjo K, van Reekum R, Verhoeff NP. Alzheimer's disease and infection: do infectious agents contribute to progression of Alzheimer's disease? Alzheimers Dement. 2009 Jul;5(4):348-60.
  43. Yilmaz N. “Relationship between paraoxonase and homocysteine: crossroads of oxidative diseases.” Arch Med Sci. 8.1: 138-53.
  44. Daviglus ML, et al. “Risk Factors and Preventive Interventions for Alzheimer’s disease: State of the Science.” Arch Neurol. 68.9 (2011): 1185-90.
  45. Harrison FE. “A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer’s disease.” J Alzheimer’s Dis. 29.4 (2012): 711-26.
  46. Hinterberger M and Fischer P. “Folate and Alzheimer: when time matters.” J Neural Transm. 2012 May 25. [Epub ahead of print]
  47. Luchsinger JA, Cheng D, Tang MX, et al. Central obesity in the elderly is related to late-onset Alzheimer disease. Alzheimer Dis Assoc Disord. 2012 Apr;26(2): 101-5.
  48. van Himbergen TM, et al. “Biomarkers for Insulin Resistance and Inflammation and the Risk for All-Cause Dementia and Alzheimer Disease: Results From the Framingham Heart Study.” Arch Neurol. (2012): Epub ahead of print January 2, 2012. doi:10.1001/archneurol.2011.670.
  49. Blum S, et al. “Memory after Silent Stroke: Hippocampus and Infarcts Both Matter.” Neurology. 78.1 (2012): 38-46.
  50. Kalaria RN, Akinyemi R, and Ihara M. Does Vascular Pathology Contribute to Alzheimer Changes? [In Eng] J Neurol Sci. 2012 Aug 9;
  51. Alzheimer’s Association. Diagnosis of Alzheimer’s Disease and Dementia. 2012. Available at: http://www.alz.org/alzheimers_disease_diagnosis.asp. Accessed May 24, 2012a.
  52. Uzun S, Kozumplik O, Folnegovic-Smalc V. “Alzheimer’s Dementia: Current Data Review.” Coll Antropol. 2011 Dec;35(4):1333-7.
  53. Kasper DL, et al., eds. Harrison’s Principles of Internal Medicine, 16th ed. McGraw-Hill, New York, 2004.
  54. Engelborghs S, Le Bastard N. “The impact of cerebrospinal fluid biomarkers on the diagnosis of Alzheimer’s disease.” Mol Diagn Ther. 16.3 (2012): 135-41.
  55. Pangalos MN, et al. “Drug Development for CNS Disorders: Strategies for Balancing Risk and Reducing Attrition.” Nat Rev Drug Discov. 6 (2007): 521-32.
  56. Food and Drug Administration (FDA). Drugs page. Drugs to be Discontinued. Available at: http://www.fda.gov/Drugs/DrugSafety/DrugShortages/ucm050794.htm. Last updated 5/28/2013. Accessed 5/28/2013.
  57. Meng Q, Ru J, Zhang G, et al. Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes. Toxicol Lett. 2007 Jan 30;168(2):140-7.
  58. Mehta M, Adem A, and Sabbagh M. New Acetylcholinesterase Inhibitors for Alzheimer's Disease. Int J Alzheimers Dis. 2012;2012:728983.
  59. Gauthier S, et al. “Can We Do Better in Developing New Drugs for Alzheimer’s Disease?” Alzheimers Dement. 5.6 (2009): 489-91.
  60. Hansen RA, et al. “Efficacy and Safety of Donepezil, Galantamine, and Rivastigmine for the Treatment of Alzheimer’s Disease: A Systematic Review and Meta-Analysis.” Clin Interv Aging. 3.2 (2008): 211-25.
  61. Lo D and Grossberg GT. Use of memantine for the treatment of dementia. Expert Rev Neurother. 2011 Oct;11(10):1359-70.
  62. Creeley CE, et al. “Donepezil Markedly Potentiates Memantine Neurotoxicity in the Adult Rat Brain.” Neurobiol Aging. 29.2 (2008): 153-67.
  63. Sastre M, Gentleman SM. NSAIDs: How they Work and their Prospects as Therapeutics in Alzheimer's Disease. Front Aging Neurosci. 2010 May 18;2:20.
  64. Hayden K. M., Zandi P. P., Khachaturian A. S., et al. Cache County Investigators (2007). Does NSAID use modify cognitive trajectories in the elderly? The Cache County study. Neurology 69, 275–282.
  65. Sostres C, Gargallo CJ, Arroyo MT, et al. “Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract.” Best Prac Res Clin Gastroenterol. 24.2 (2010):121-32.
  66. William BW, Cruz C. “Impact of NSAIDs on Cardiovascular Risk and Hypertension.” Ital J Med. 5.3 (2011):175-183.
  67. Ejaz P, Bhojani K, Joshi VR. NSAIDs and kidney. J Assoc Physicians India. 2004 Aug;52:632-40.
  68. Qiu C. Preventing Alzheimer's Disease by Targeting Vascular Risk Factors: Hope and Gap. J Alzheimers Dis. 2012 Jul 27. [Epub ahead of print]
  69. Shah NS, Vidal JS, Masaki K. Midlife blood pressure, plasma β-amyloid, and the risk for Alzheimer disease: the Honolulu Asia Aging Study. Hypertension. 2012 Apr;59(4):780-6. Epub 2012 Mar 5.
  70. Qiu C, et al. “Vascular and Psychosocial Factors in Alzheimer’s Disease: Epidemiological Evidence toward Intervention.” J Alzheimers Dis. 20.3 (2010): 689-97.
  71. Forette F, et al. “Prevention of Dementia in Randomised Double-Blind Placebo-Controlled Systolic Hypertension in Europe (Syst-Eur) Trial.” Lancet. 352.9137 (1998): 1347-51.
  72. Hajjar IM, et al. “Angiotensin Converting Enzyme Inhibitors and Cognitive and Functional Decline in Patients with Alzheimer’s Disease: An Observational Study.” Am J Alzheimers Dis Other Demen. 23.1 (2008): 77-83.
  73. Trenkwalder P. “The Study on Cognition and Prognosis in the Elderly (SCOPE)—Recent Analyses.” J Hypertens Suppl. 24.1 (2006): S107-14.
  74. Tobinick EL and Gross H. “Rapid cognitive improvement in Alzheimer’s disease following perispinal etanercept administration.” J Neuroinflammation. 5 (2008b): 2.
  75. Tobinick EL. “Deciphering the Physiology Underlying the Rapid Clinical Effects of Perispinal Etanercept in Alzheimer’s disease.” Curr Alzheimer Res. 9.1 (2012): 99-109.
  76. Jiang H, et al. “Granulocyte Colony-Stimulating Factor Attenuates Chronic Neuroinflammation in the Brain of Amyloid Precursor Protein Transgenic Mice: An Alzheimer’s Disease Mouse Model.” J Int Med Res. 38.4 (2010): 1305-12.
  77. Laske C, et al. “Decreased Plasma Levels of Granulocyte-Colony Stimulating Factor (G-CSF) in Patients with Early Alzheimer’s Disease.” J Alzheimers Dis. 17.1 (2009): 115-23.
  78. Tsai KJ, et al. “G-CSF Rescues the Memory Impairment of Animal Models of Alzheimer’s Disease.” J Exp Med. 204.6 (2007): 1273-80.
  79. Clinicaltrials.gov. NCT01617577. Efficacy and Safety of Filgrastim in Alzheimer's Disease (FFAD) Available at: http://clinicaltrial.gov/ct2/show/NCT01617577?term=Granulocyte+Colony-stimulating+Factor&rank=15 Accessed 7/25/2012.
  80. Li G, et al. “Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor and Cognitive Function in Non-Demented Subjects.” PLoS One. 4.5 (2009): Epub ahead of print May 1, 2009.
  81. Nagahara AH, et al. “Neuroprotective Effects of Brain-Derived Neurotrophic Factor in Rodent and Primate Models of Alzheimer’s Disease.” Nat Med. 15.3 (2009): 331-7.
  82. Schulte-Herbrüggen O, Jockers-Scherübl MC, Hellweg R. Neurotrophins: from pathophysiology to treatment in Alzheimer's disease. Curr Alzheimer Res. 2008 Feb;5(1):38-44.
  83. Nunes PV, et al. “Lithium and Risk for Alzheimer’s Disease in Elderly Patients with Bipolar Disorder.” Br J Psychiatry. 190 (2007): 359-60.
  84. Forlenza OV, et al. “Disease-Modifying Properties of Long-Term Lithium Treatment for Amnestic Mild Cognitive Impairment: Randomised Controlled Trial.” Br J Psychiatry. 198 (2011): 351-6.
  85. Forlenza OV, de Paula VJ, Machado-Vieira R, et al. Does lithium prevent Alzheimer's disease? Drugs Aging. 2012 May 1;29(5):335-42.
  86. McDonnell DP, Connor CE, Wijayaratne A, et al. “Definition of the Molecular and Cellular Mechanisms Underlying the Tissue-selective Agonist/Antagonist Activities of Selective Estrogen Receptor Modulators.” Endocrine Reviews. 57.1 (2002): 295-316.
  87. O’Neill, et al. “Impact of the Selective Estrogen Receptor Modulator, Tamoxifen, on Neuronal Outgrowth and Survival following Toxic Insults Associated with Aging and Alzheimer’s disease.” Exp Neurol. 2004 Aug;188(2):268-78.
  88. Yaffe K, et al. “Effect of Raloxifene on Prevention of Dementia and Cognitive Impairment in Older Women: The Multiple Outcomes of Raloxifene (MORE) Randomized Trial.” Am J Psychiatry. 2005 Apr;162(4):683-90.
  89. St. George-Hyslop PH, et al. “Will Anti-Amyloid Therapies Work for Alzheimer’s Disease?” Lancet. 2008 Jul 19;372(9634):180-2.
  90. Aranda-Abreu GE, et al. “Rehabilitating a Brain with Alzheimer’s: A Proposal.” Clin Interv Aging. 6 (2011): 53-9.
  91. Loeb MB, Molloy DW, Smieja M, et al. A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer's disease. J Am Geriatr Soc. 2004 Mar;52(3):381-7.
  92. Tsai GE, k WE, Gunther J, et al. Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment. Am J Psychiatry. 1999 Mar;156(3):467-9.
  93. Malyka AG et al. Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders. Drugs. 2010 Feb 12;70(3):287-312.
  94. Muller WE et al. Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain. Biochem Pharmacol. 1997 Jan 24;53(2):135-40.
  95. Waegemans T et al. Clinical efficacy of piracetam in cognitive impairment: a meta-analysis. Dement Geriatr Cogn Disord. 2002;13(4):217-24.
  96. Sanchez PE, Zhu L, Verret L, et al. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc Natl Acad Sci U S A. 2012 Aug 6. [Epub ahead of print]
  97. Cai Z, et al. “Mammalian Target of Rapamycin: A Valid Therapeutic Target through the Autophagy Pathway for Alzheimer’s disease?” J Neurosci Res. 90.6 (2012): 1105-18.
  98. Fleisher AS, et al. “Phase 2 Safety Trial Targeting Amyloid Beta Production with a Gamma-Secretase Inhibitor in Alzheimer Disease.” Arch Neurol. 65.8 (2008): 1031-8.
  99. Miller WL, “Androgen Biosynthesis from Cholesterol to DHEA.” Mol Cell Endocrinol. 198.1-2 (2002): 7-14.
  100. Luu-The V, Labrie F. “The Intracrine Sex Steroid Biosynthesis Pathways.” Prog Brain Res. 181. (2010): 177-92.
  101. Mayo W, et al. “Individual Differences in Cognitive Aging: Implication of Pregnenolone Sulfate.” Prog Neurobiol. 2003 Sep;71(1):43-8.
  102. Mayo W, et al. “Pregnenolone Sulfate Enhances Neurogenesis and PSA-NCAM in Young and Aged Hippocampus.” Neurobiol Aging. 2005 Jan;26(1):103-14.
  103. Hillen T, et al. “DHEA-S Plasma Levels and Incidence of Alzheimer’s Disease.” Biol Psychiatry. 47.2 (2000): 161-3.
  104. Polleri A, et al. “Dementia: A Neuroendocrine Perspective.” J Endocrinol Invest. 25.1 (2002): 73-83.
  105. Weill-Engerer S, et al. “Neurosteroid Quantification in Human Brain Regions: Comparison between Alzheimer’s and Nondemented Patients.” J Clin Endocrinol Metab. 87.11 (2002): 5138-43.
  106. Farr SA, et al. “DHEAS Improves Learning and Memory in Aged SAMP8 Mice but Not in Diabetic Mice.” Life Sci. 75.2 (2004): 2775-85.
  107. Zhang S and Yao T. [Estrogen: regulation of amyloid-beta protein metabolism and attenuation of amyloid-beta protein neurotoxicity]. Sheng Li Ke Xue Jin Zhan. 2003 Jul;34(3):197-201.
  108. Bailey ME, Wang AC, Hao J, et al. teractive effects of age and estrogen on cortical neurons: implications for cognitive aging. Neuroscience. 2011 Sep 15;191:148-58.
  109. Maki PM and Henderson VW. Hormone therapy, dementia, and cognition: the Women's Health Initiative 10 years on. Climacteric. 2012 Jun;15(3):256-62.
  110. Brinton RD. “Investigative Models for Determining Hormone Therapy-Induced Outcomes in Brain: Evidence in Support of a Healthy Cell Bias of Estrogen Action.” Ann N Y Acad Sci. 2005 Jun;1052:57-74.
  111. Zandi PP, Carlson MC, Plassman BL, et al. Hormone replacement therapy and incidence of Alzheimer disease in older women: the CacheCounty Study. JAMA. 2002 Nov 6;288(17):2123-9.
  112. Carroll JC and Rosario ER. “The Potential Use of Hormone-Based Therapeutics for the Treatment of Alzheimer’s Disease.” Curr Alzheimer Res. 2012 Jan;9(1):18-34.
  113. Schumacher M, et al. “Local Synthesis and Dual Actions of Progesterone in the Nervous System: Neuroprotection and Myclination.” Growth Horm IGF Res. 14.A (2004):S18-33.
  114. Lu PH, Masterman DA, Mulnard R, et al. Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men. Arch Neurol. 2006 Feb;63(2):177-85.
  115. Bubenik GA and Konturek SJ. “Melatonin and aging: prospects for human treatment.” J Physiol Pharmacol. 62.1 (2011): 13-9.
  116. Magri F, Sarra S, Cinchetti W, et al. Qualitative and quantitative changes of melatonin levels in physiological and pathological aging and in centenarians. J Pineal Res. 2004 May;36(4):256-61.
  117. Cardinali DP, Furio AM, Brusco LI. “The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer’s disease.” Recent Pat Endocr Metab Immune Drug Discov. 5.2 (2011): 80-90.
  118. Cheng Y, et al. “Beneficial Effects of Melatonin in Experimental Models of Alzheimer Disease.” Acta Pharmacol Sin. 27.2 (2006): 129-39
  119. Wang JZ, et al. “Role of Melatonin in Alzheimer-Like Neurodegeneration.” Acta Pharmacol Sin. 27.1 (2006a): 41-9.
  120. Srinivasan V, et al. “Melatonin in Alzheimer’s Disease and Other Neurodegenerative Disorders.” Behav Brain Funct. 4.2 (2006): 15.
  121. Gu Y, et al. “Dietary Patterns in Alzheimer’s Disease and Cognitive Aging.” Curr Alzheimer Res. 8.5 (2011): 510-9.
  122. Demarin V, et al. “Mediterranean Diet in Healthy Lifestyle and Prevention of Stroke.” Acta Clin Croat. 50.1 (2011): 67-77.
  123. Solfrizzi V, et al. “Mediterranean Diet in Predementia and Dementia Syndromes.” Curr Alzheimer Res. 2011 Aug;8(5):520-42.
  124. Scarmeas N, et al. “Mediterranean Diet and Mild Cognitive Impairment.” Arch Neurol. 66.2 (2009): 216-25.
  125. Scarmeas N, et al. “Mediterranean Diet and Alzheimer Disease Mortality.” Neurology. 69 (2007): 1084-93.
  126. Jóźwiak S, et al. “Dietary Treatment of Epilepsy: Rebirth of an Ancient Treatment.” Neurol Neurochir Pol. 45.4 (2011): 370-8.
  127. Van der Auwera I, Wera S, Van Leuven F, et al. “A ketogenic diet reduces amyloid beta 40 and 42 in mouse model of Alzheimer’s disease.” Nutr Metab (Lond). 2 (2005):28.
  128. Geda Y, et al. “Caloric Intake, Aging, and Mild Cognitive Impairment: A Population-Based Study.” Presented at the 64th Annual Meeting of the American Academy of Neurology. New Orleans. April 21-28, 2012.
  129. Pasinetti GM, Zhao Z, Qin W, et al. Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implications. Interdiscip Top Gerontol. 2007;35:159-75.
  130. Cotman CW, et al. “Exercise Builds Brain Health: Key Roles of Growth Factor Cascades and Inflammation.” Trends Neurosci. 30.9 (2007): 464-72.
  131. van Praag H. “Exercise and the Brain: Something to Chew On.” Trends Neurosci. 32.5 (2009): 283-90.
  132. Burns JM, et al. “Cardiorespiratory Fitness and Brain Atrophy in Early Alzheimer Disease.” Neurology. 71.3 (2008): 210-6.
  133. Winter B et al. High impact running improves learning. Neurobiol Learn Mem. 2007 May;87(4):597-609
  134. Gomez-Pinilla F, et al. “Brain-Derived Neurotrophic Factor Functions as a Metabotrophin to Mediate the Effects of Exercise on Cognition.” Eur J Neurosci. 28.11 (2008): 2278-87.
  135. Wu A, et al. “Dietary Omega-3 Fatty Acids Normalize BDNF Levels, Reduce Oxidative Damage, and Counteract Learning Disability after Traumatic Brain Injury in Rats.” J Neurotrauma. 21.10 (2004a): 1457-67.
  136. Wang XD, Zhang JM, Yang HH, et al. Modulation of NMDA receptor by huperzine A in rat cerebral cortex. Zhongguo Yao Li Xue Bao. 1999 Jan;20(1):31-5.
  137. Sun QQ, et al. “Huperzine-A Capsules Enhance Memory and Learning Performance in 34 Pairs of Matched Adolescent Students.” Zhongguo Yao Li Xue Bao. 20.7 (1999): 601-3.
  138. Wang R, et al. “Progress in Studies of Huperzine A: A Natural Cholinesterase Inhibitor from Chinese Herbal Medicine.” Acta Pharmacol Sin. 27.1 (2006b): 1-26.
  139. Bai DL, et al. “Huperzine A: A Potential Therapeutic Agent for Treatment of Alzheimer’s Disease.” Curr Med Chem. 7.3 (2000): 355-74.
  140. Rafii MS, Walsh S, Little JT, et al. A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology. 2011 Apr 19;76(16):1389-94.
  141. Wang BS, et al. “Efficacy and Safety of Natural Acetylcholinesterase Inhibitor Huperzine A in the Treatment of Alzheimer’s Disease: An Updated Meta-Analysis.” J Neural Transm. 116.4 (2009): 457-65.
  142. Milad SB, et al. “Inflammation and apoptosis in aortic tissues of aged type II diabetes: Amelioration with Mechanisms Underlying the Tissue-selective Agonist/Antagonist Activities of .” Life Sci. 86.23-24 (2010): 844-53.
  143. Holmquist L, et al. “Lipoic Acid as a Novel Treatment for Alzheimer’s disease and Related Dementias.” Pharmacol Thera. 113.1 (2007): 154-164.
  144. Hager K, et al. “Alpha-Lipoic Acid as a New Treatment Option for Alzheimer [corrected] Type Dementia.” Arch Gerontol Geriatr. 32.3 (2001): 275-82.
  145. Hager K, et al. “Alpha-Lipoic Acid as a New Treatment Option for Alzheimer's Disease—A 48 Months Follow-up Analysis.” J Neural Transm Suppl. 72 (2007): 189-93.
  146. Butterworth RF. “Evidence for Forebrain Cholinergic Neuronal Loss in Congenital Ornithine Transcarbamylase Deficiency.” Metab Brain Dis. 15.1 (2000): 83-91.
  147. Dhitavat S, et al. “Folate, Vitamin E, and Acetyl-L-Carnitine Provide Synergistic Protection against Oxidative Stress Resulting from Exposure of Human Neuroblastoma Cells to Amyloid-Beta.” Brain Res. 1061.2 (2005): 114-7.
  148. Virmani MA, et al. “The Action of Acetyl-L-Carnitine on the Neurotoxicity Evoked by Amyloid Fragments and Peroxide on Primary Rat Cortical Neurones.” Ann N Y Acad Sci. 939 (2001): 162-78.
  149. Ames BN, et al. “Delaying the Mitochondrial Decay of Aging with Acetylcarnitine.” Ann N Y Acad Sci. 1033 (2004): 108-16.
  150. Zhou P, et al. “Acetyl-L-Carnitine Attenuates Homocysteine-Induced Alzheimer-Like Histopathological and Behavioral Abnormalities.” Rejuvenation Res. 14.6 (2011): 669-79.
  151. Pettegrew JW, et al. “Clinical and Neurochemical Effects of Acetyl-L-Carnitine in Alzheimer’s disease.” Neurobiol Aging. 16.1 (1995) 1-4.
  152. Epis R, et al. “Modulatory Effect of Acetyl-L-Carnitine on Amyloid Precursor Protein Metabolism in Hippocampal Neurons.” Eur J Pharmocol. 597.1-3 (2008): 51-53.
  153. Christensen LP. “Ginsenosides chemistry, biosynthesis, analysis, and potential health effects.” Adv Food Nutr Res. 55 (2009): 1-99.
  154. Kennedy DO, et al. “Dose Dependent Changes in Cognitive Performance and Mood Following Acute Administration of Ginseng to Healthy Young Volunteers.” Nutr Neurosci. 4.4 (2001): 295-310.
  155. Lee ST, et al. “Panax ginseng Enhances Cognitive Performance in Alzheimer Disease.” Alzheimer Dis Assoc Disord. 22.3 (2008): 222-6.
  156. Gehin A, et al. “Glyphosate-induced Antioxidant Imbalance in HaCaT: The Protective Effect of Vitamins C and E.” Environ Toxicol Pharmocol. 22.1 (2006): 27-34.
  157. Shireen KF, et al. “Effects of Dietary Vitamin E, C and Soybean Oil Supplementation on Antioxidant Enzyme Activities in Liver and Muscles of Rats.” Food Chem Toxicol. 46.10 (2008): 3290-3294.
  158. Boothby LA, Doering PL. “Vitamin C and vitamin E for Alzheimer’s disease.” Ann Pharmacother. 39.12 (2005):2073-80.
  159. Zandi PP, et al. “Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements: The Cache County Study.” Arch Neurol. 61.1 (2004): 82-8.
  160. Grundman M. “Vitamin E and Alzheimer Disease: The Basis for Additional Clinical Trials.” Am J Clin Nutr. 71.2 (2000): 630S-6S.
  161. Cheng F, et al. “Suppression of Amyloid β A11 Antibody Immunoreactivity by Vitamin C: Possible Role Of Heparan Sulfate Oligosaccharides Derived From Glypican-1 By Ascorbate-induced, Nitric Oxide (NO)-catalyzed Degradation.” J Biol Chem, 286.31 (2011): 27559-72.
  162. Ciabattoni G, et al. “Determinants of Platelet Activation in Alzheimer’s Disease.” Neurobiol Aging. 28.3 (2007): 336-72. Epub ahead of print January 24, 2006.
  163. Galbusera C, et al. “Increased Susceptibility to Plasma Lipid Peroxidation in Alzheimer Disease Patients.” Curr Alzheimer Res. 1.2 (2004): 103-9.
  164. Landmark K. “Could Intake of Vitamins C and E Inhibit Development of Alzheimer Dementia?” [in Norwegian]. Tidsskr Nor Laegeforen. 126.2 (2006): 159-61.
  165. Mas E, et al. “Functional Vitamin E Deficiency in ApoE4 Patients with Alzheimer’s Disease.” Dement Geriatr Cogn Disord. 21.3 (2006): 198-204.
  166. McCann SM, et al. “The Nitric Oxide Theory of Aging Revisited.” Ann N Y Acad Sci. 1057 (2005): 64-84.
  167. Pocernich CB, et al. “Nutritional Approaches to Modulate Oxidative Stress in Alzheimer’s Disease.” Curr Alzheimer Res. 8.5 (2011): 452-69.
  168. Diamond BJ, et al. “Ginkgo biloba Extract: Mechanisms and Clinical Indications.” Arch Phys Med Rehab. 81.5 (2000): 668-78.
  169. Perry EK, et al. “Medicinal Plants and Alzheimer’s Disease: From Ethnobotany to Phytotherapy.” J Pharm Pharmacol. 51.5 (1999): 527-34.
  170. Schneider LS, et al. “A Randomized, Double-Blind, Placebo-Controlled Trial of Two Doses of Ginkgo biloba Extract in Dementia of the Alzheimer’s Type.” Curr Alzheimer Res. 2.5 (2005): 541-51.
  171. Yao ZX, et al. “Ginkgo biloba Extract (Egb 761) Inhibits Beta-Amyloid Production by Lowering Free Cholesterol Levels.” J Nutr Biochem. 15.12 (2004): 749-56.
  172. Mashayekh A, et al. “Effects of Ginkgo biloba on Cerebral Blood Flow Assessed by Quantitative MR Perfusion Imaging: A Pilot Study.” Neuroradiology. 53.3 (2011): 185-91.
  173. Araujo JA, et al. “Improvement of Short-Term Memory Performance in Aged Beagles by a Nutraceutical Supplement Containing Phosphatidylserine, Ginkgo biloba, Vitamin E, and Pyridoxine.” Can Vet J. 49.4 (2008): 379-85.
  174. Kennedy DO, et al. “Acute Cognitive Effects of Standardised Ginkgo Biloba Extract Complexed with Phosphatidylserine.” Hum Psychopharmacol. 22.4 (2007): 199-210.
  175. Longpré F, et al. “Protection by EGb 761 against Beta-Amyloid-Induced Neurotoxicity: Involvement of NF-KappaB, SIRT1, and Mapks Pathways and Inhibition of Amyloid Fibril Formation.” Free Radic Biol Med. 41.12 (2006): 1781-94.
  176. Janssen IM, et al. “Ginkgo biloba in Alzheimer’s Disease: A Systematic Review.” Wien Med Wochenschr. 160.21-22 (2010): 539-46.
  177. Begum AN, et al. “Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease.” J Pharmacol Exp Ther. 326.1 (2008): 196-208.
  178. Mishra S, et al. “The Effect of Curcumin (Turmeric) on Alzheimer’s Disease: An Overview.” Ann Indian Acad Neurol. 11.1 (2008): 13-9.
  179. Ringman JM, et al. “A Potential Role of the Curry Spice Curcumin in Alzheimer’s Disease.” Curr Alzheimer Res. 2.2 (2005): 131-6.
  180. Walker D, et al. “Anti-Inflammatory and Immune Therapy for Alzheimer’s Disease: Current Status and Future Directions.” Curr Neuropharmacol. 5.4 (2007): 232-43.
  181. Cole GM, et al. “NSAID and Antioxidant Prevention of Alzheimer’s Disease: Lessons from in Vitro and Animal Models.” Ann N Y Acad Sci. 1035 (2004): 68-84.
  182. Aggarwal BB, et al. “Suppression of the Nuclear Factor-KappaB Activation Pathway by Spice-Derived Phytochemicals: Reasoning for Seasoning.” Ann N Y Acad Sci. 1030 (2004): 434-41.
  183. Baum L, et al. “Curcumin Interaction with Copper and Iron Suggests One Possible Mechanism of Action in Alzheimer’s Disease Animal Models.” J Alzheimers Dis. 6.4 (2004): 367-77.
  184. Yang F, et al. “Curcumin Inhibits Formation of Amyloid Beta Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo.” J Biol Chem. 280.7 (2005): 5892-901.
  185. Baum L, Lam CW, Cheung SK, et al. Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients with Alzheimer Disease. [In eng] J Clin Psychopharmacol. 2008 Feb; 28(1): 110-3.
  186. Swanson D, et al. “Omega-3 fatty acids DHA and EPA: Health Benefits throughout Life.” Adv Nutr. 3.1 (2012): 1-7
  187. Young G, et al. “Omega-3 Fatty Acids and Neuropsychiatric Disorders.” Reprod Nutr Dev 45.1 (2005): 1-28.
  188. Lukiw WJ, et al. “A Role for Docosahexaenoic Acid-Derived Neuroprotectin D1 in Neural Cell Survival and Alzheimer Disease.” J Clin Invest. 115.10 (2005): 2774-83.
  189. Akbar M, et al. “Docosahexaenoic Acid: A Positive Modulator of Akt Signaling in Neuronal Survival.” Proc Natl Acad Sci USA. 102.31 (2005): 10858-63.
  190. Ma QL, et al. “Beta-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via C-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin.” J Neurosci. 29.28 (2009): 9078-89.
  191. Amtul Z, et al. “Structural Basis for the Differential Effects of Omega-3 and Omega-6 Fatty Acids on Abeta Production and Amyloid Plaques.” J Biol Chem. (2010): Epub ahead of print October 22, 2010.
  192. Kariv-Inbal Z, Yacobson S, Berkecz R, et al. The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol. J Alzheimers Dis. 2012;28(3):667-83.
  193. Yurko-Mauro K, et al. “Beneficial Effects of Docosahexaenoic Acid on Cognition in Age-Related Cognitive Decline.” Alzheimers Dement. 6.6 (2010): 456-64.
  194. Szilagyi G, et al. “Effects of Vinpocetine on the Redistribution of Cerebral Blood Flow and Glucose Metabolism in Chronic Ischemic Stroke Patients: A PET Study.” J Neurol Sci. Mar 15 (2005); 229-230: 275-84.
  195. Dézsi L, et al. “Neuroprotective Effects of Vinpocetine in Vivo and in Vitro: Apovincaminic Acid Derivatives as Potential Therapeutic Tools in Ischemic Stroke” [in Hungarian]. Acta Pharm Hung. 72.2 (2002): 84-91.
  196. Pereira C, et al. “Neuroprotection Strategies: Effect of Vinpocetine in Vitro Oxidative Stress Models” [in Portuguese]. Acta Med Port. 16.6 (2003): 401-6.
  197. Sitges M, et al. “Vinpocetine Blockade of Sodium Channels Inhibits the Rise in Sodium and Calcium Induced by 4-Aminopyridine in Synaptosomes.” Neurochem Int. 46.7 (2005): 533-40.
  198. Adám-Vizi V. “Neuroprotective Effect of Sodium Channel Blockers in Ischemia: The Pathomechanism of Early Ischemic Dysfunction” [in Hungarian]. Orv Hetil. 141.23 (2000): 1279-86.
  199. [No authors listed]. Vinpocetine Monograph. Altern Med Rev. 2002;7(3): 240-3. Availabe at: http://www.altmedrev.com/publications/7/3/240.pdf Accessed 7/25/2012.
  200. Balestreri R, Fontana L, Astengo F. A double-blind placebo controlled evaluation of the safety and efficacy of vinpocetine in the treatment of patients with chronic vascular senile cerebral dysfunction. J Am Geriatr Soc. 1987 May;35(5):425-30.
  201. Chowanadisai W, et al. “Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression.” J Biol Chem. 285.1 (2010): 142-152.
  202. Tao R, et al. “Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in Alzheimer’s diseaseult rat cardiac myocytes.” Biochem Biophys Res Commune. 363.2 (2007):257-262. Epub ahead of printTarawneh R and Holtzman DM. The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment. Cold Spring Harb Perspect Med. 2012;2(5):a006148.
  203. Facecchia K, et al. “Oxidative Toxicity in Neurodegenerative Diseases: Role of Mitochondrial Dysfunction and Therapeutic Strategies.” J Toxicol. 2011 (2011): 683728. Epub ahead of print July 14, 2011.
  204. Martin LJ. “Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.” Pharmaceuticals (Basel). 3.4 (2010): 839-915.
  205. Kim J, et al. “The Inhibitory Effect of Pyrroloquinoline Quinone on the Amyloid Formation and Cytotoxicity of Truncated Alpha-Synuclein.” Mol Neurodegener. 5 (2010): 20.
  206. Liu S, et al. “Enhanced Rat Sciatic Nerve Regeneration through Silicon Tubes Filled with Pyrroloquinoline Quinone.” Microsurgery. 25.4 (2005): 329-37.
  207. Murase K, et al. “Stimulation of Nerve Growth Factor Synthesis/Secretion in Mouse Astroglial Cells by Coenzymes.” Biochem Mol Biol Int. 30.4 (1993): 615-21.
  208. Yamaguchi K, et al. “Stimulation of Nerve Growth Factor Production by Pyrroloquinoline Quinone and Its Derivatives in Vitro and in Vivo.” Biosci Biotechnol Biochem. 57.7 (1993): 1231-3.
  209. Zhang JJ, et al. “Protective Effect of Pyrroloquinoline Quinone against Abeta-Induced Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells.” Neurosci Lett. 464.3 (2009): 165-9.
  210. Nakano M, Ubukata K, Yamamoto T, Yamaguchi H. Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons. FOOD Style. 2009;21:13(7):50-3.
  211. Kato-Kataoka A, et al. “Soybean-derived Phosphatidylserine Improves Memory Functions of the Elderly Japanese Subjects with Memory Complaints.” J Clin Biochem Nutr. 47.3 (2010) 246-55.
  212. Schreiber S, et al. “An Open Trial of Plant-Source Derived Phosphatydilserine for Treatment of Age-Related Cognitive Decline.” Isr J Psychiatry Relat Sci. 37.4 (2000): 302-7.
  213. Richter Y, et al. “The Effect of Phosphatidylserine-containing Omega-3 Fatty Acids on Memory Abilities in Subjects with Subjective Memory Complaints: A Pilot Study.” Clin Interv Aging. 5 (2010): 313-6.
  214. Shyh-Hwa L, et al. “Docosahexaenoic Acid and Phosphatidylserine Supplementations Improve Antioxidant Activities and Cognitive Functions of the Developing Brain on Pentylenetetrazol-Induced Seizure Model.” Brain Res. 1451. (2012): 19-26.
  215. Walter A, et al. “ Glycerophosphocholine is Elevated in Cerebrospinal Fluid of Alzheimer Patients.” Neurobiol Aging. 25.10 (2004): 1299-303.
  216. Suchy J, et al. “Dietary supplementation with a combination of α-lipoic acid, acetyl-l-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance.” Nut Res. 29.1 (2009): 70-74.
  217. Moreno M. “Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetycholine precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial.” Clin Ther. 25.1 (2003): 178-93.
  218. Barbagallo M, et al. “Altered Ionised Magnesium Levels in Mild-to-Moderate Alzheimer’s Disease.” Magnes Res. 24.3 (2011): S115-21.
  219. Butt MS, et al. “Coffee and Its Consumption: Benefits and Risks.” Crit Rev Food Sci Nutr. 51.4 (2011): 363-73.
  220. Cao C, et al. “Caffeine Synergizes with Another Coffee Component to Increase Plasma GCSF: Linkage to Cognitive Benefits in Alzheimer’s Mice.” J Alzheimers Dis. 25.2 (2011): 323-35.
  221. Montagnana M, et al. “Coffee Intake and Cardiovascular Disease: Virtue Does Not Take Center Stage.” Semin Thromb Hemos. 38.2 (2012): 164-77. Epub February 18, 2012.
  222. Kwon SH, et al. “Neuroprotective Effects of Chlorogenic Acid on Scopolamine-Induced Amnesia via Anti-Acetylcholinesterase and Anti-Oxidative Activities in Mice.” Eur J Pharmacol. 649.1-3 (2010): 210-7.
  223. Zapp LM, Slaga TJ, Zhao J. et al. Method for enhancing post-processing content of beneficial compounds in beverages naturally - United States Patent Application 20100183790. Publication Date: 2010-07-22. Available at: http://patent.ipexl.com/U2S/20100183790.html accessed 7/25/2012.
  224. Jaiswal R, et al. “Profile and characterization of the chlorogenic acids in green Robusta coffee beans by LC-MS(n): identification of seven new classes of compounds.” J Agric Food Chem. 58.15 (2010): 8722-37.
  225. Rezai-Zadeh K, et al. “Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice.” J Neurosci. 25.38 (2005): 8807-14.
  226. Haque AM, et al. “Green Tea Catechins Prevent Cognitive Deficits Caused by Abeta1-40 in Rats.” J Nutr Biochem. 19.9 (2008): 619-26.
  227. Kim TI, et al. “L-Theanine, an Amino Acid in Green Tea, Attenuates Beta-Amyloid-Induced Cognitive Dysfunction and Neurotoxicity: Reduction in Oxidative Damage and Inactivation of ERK/p38 Kinase and NF-kappaB Pathways.” Free Radic Biol Med. 47.11 (2009): 1601-10.
  228. Rezai-Zadeh K, et al. “Green Tea Epigallocatechin-3-Gallate (EGCG) Reduces Beta-Amyloid Mediated Cognitive Impairment and Modulates Tau Pathology in Alzheimer Transgenic Mice.” Brain Res. 12.1214 (2008): 177-87.
  229. Mandel SA, et al. “Understanding the Broad-Spectrum Neuroprotective Action Profile of Green Tea Polyphenols in Aging and Neurodegenerative Diseases.” J Alzheimers Dis. 25.2 (2011): 187-208.
  230. Kim D, et al. “SIRT1 Deacetylase Protects against Neurodegeneration in Models for Alzheimer’s Disease and Amyotrophic Lateral Sclerosis.” EMBO J. 26.13 (2007): 3169-79.
  231. Vingtdeux V, Dreses-Werringloer U, Zhao H, et al. “Therapeutic potential of resveratrol in Alzheimer’s disease.” BMC Neurosci. 9(Suppl 2) (2008): S6.
  232. Ho L, et al. “Heterogeneity in Red Wine Polyphenolic Contents Differentially Influences Alzheimer’s Disease-Type Neuropathology and Cognitive Deterioration.” J Alzheimers Dis. 16.1 (2009): 59-72.
  233. Richard T, et al. “Neuroprotective Properties of Resveratrol and Derivatives.” Ann N Y Acad Sci. 1215 (2011): 103-8.
  234. Ladiwala ARA, et al. “Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Beta into Off-Pathway Conformers.” J Biol Chem. 285 (2010): 24228-37.
  235. Shi J, et al. “Polyphenolics in Grape Seeds: Biochemistry and Functionality.” J Med Food. 6.4 (2003): 291-9.
  236. Li MH, et al. “Protective Effects of Oligomers of Grape Seed Polyphenols against Beta-Amyloid-Induced Oxidative Cell Death.” Ann NY Acad Sci. 1030 (2004): 317-29.
  237. Wang J, et al. “Grape-Derived Polyphenolics Prevent Alpha Beta Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer’s Disease.” J Neurosci. 28.25 (2008): 6388-92.
  238. Bardgett ME, et al. “Magnesium Deficiency Impairs Fear Conditioning in Mice.” Brain Res. 1038.1 (2005): 100-6.
  239. Corsonello A, et al. “Serum Magnesium Levels and Cognitive Impairment in Hospitalized Hypertensive Patients.” Magnes Res. 14.4 (2001): 273-82.
  240. Barbagallo Sangiorgi G, et al. "Alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks." An Italian multicenter clinical trial. Ann NY Acad Sci 1994; 717:253-69.
  241. Slutsky I, et al. “Enhancement of Learning and Memory by Elevating Brain Magnesium.” Neuron. 65.2 (2010): 165-77.
  242. Quadri P, et al. “Homocysteine and B Vitamins in Mild Cognitive Impairment and Dementia.” Clin Chem Lab Med. 43.10 (2005): 1096-100.
  243. Ravaglia G, et al. “Homocysteine and Folate as Risk Factors for Dementia and Alzheimer Disease.” Am J Clin Nutr. 82.3 (2005): 636-43.
  244. Tucker KL, et al. “High Homocysteine and Low B Vitamins Predict Cognitive Decline in Aging Men: The Veterans Affairs Normative Aging Study.” Am J Clin Nutr. 82.3 (2005): 627-35.
  245. Engelborghs S, et al. “Correlations between Cognitive, Behavioural and Psychological Findings and Levels of Vitamin B12 and Folate in Patients with Dementia.” Int J Geriatr Psychiatry. 19.4 (2004): 365-70.
  246. Wang HX, et al. “Vitamin B(12) and Folate in Relation to the Development of Alzheimer’s Disease.” Neurology. 56.9 (2001): 1188-94.
  247. Mizrahi EH, et al. “Plasma Total Homocysteine Levels, Dietary Vitamin B6 and Folate Intake in AD and Healthy Aging.” J Nutr Health Aging. 7.3 (2003): 160-5.
  248. Mulder C, et al. “Low Vitamin B6 Levels Are Associated with White Matter Lesions in Alzheimer’s Disease.” J Am Geriatr Soc. 53.6 (2005): 1073-4.
  249. Serot JM, et al. “CSF-Folate Levels Are Decreased in Late-Onset AD Patients.” J Neural Transm. 108.1 (2001): 93-9.
  250. Kado DM, et al. “Homocysteine versus the Vitamins Folate, B6, and B12 as Predictors of Cognitive Function and Decline in Older High-Functioning Adults: MacArthur Studies of Successful Aging.” Am J Med. 118.2 (2005): 161-7.
  251. Morris MC, et al. “Dietary Niacin and the Risk of Incident Alzheimer’s Disease and of Cognitive Decline.” J Neurol Neurosurg Psychiatry. 75.8 (2004): 1093-9.
  252. Eyles DW, et al. “Distribution of the Vitamin D Receptor and 1α-hydroxylase in Human Brain.” J Chem Neuroanat. 29.1 (2005): 21-30.
  253. Ito S, et al. “1-alpha,25-Dihydroxyvitamin D3 Enhances Cerebral Clearance of Human Amyloid-Β Peptide(1-40) from Mouse Brain across the Blood-Brain Barrier.” Fluids Barriers CNS. 8 (2011): 20.
  254. Annweiler C, Rolland Y, Schott AM, et al. Higher Vitamin D Dietary Intake Is Associated with Lower Risk of Alzheimer's Disease: A 7-Year Follow-Up. [In Eng] J Gerontol A Biol Sci Med Sci. 2012 Apr 13;
  255. Galpern WR, et al. “Coenzyme Q Treatment of Neurodegenerative Diseases of Aging.” Mitochondrion. 7 Supp (2007): S146-53.
  256. Manacuso M, et al. “Coenzyme Q10 in Neuromuscular and Neurodegenerative Disorders.” Curr Drug Targets. 11.1 (2010): 111-21.
  257. Dhanasekaran M, et al. “The Emerging Role of Coenzyme Q-10 in Aging, Neurodegeneration, Cardiovascular Disease, Cancer and Diabetes Mellitus.” Curr Neurovasc Res. 2.5 (2005): 447-59.
  258. Kidd PM. “Neurodegeneration from Mitochondrial Insufficiency: Nutrients, Stem Cells, Growth Factors, and Prospects for Brain Rebuilding Using Integrative Management.” Altern Med Rev. 10.4 (2005): 268-93.
  259. Moreira PI, et al. “CoQ10 Therapy Attenuates Amyloid Beta-Peptide Toxicity in Brain Mitochondria Isolated from Aged Diabetic Rats.” Exp Neurol. 196.1 (2005): 112-9.
  260. Yang X, et al. “Coenzyme Q10 Attenuates Beta-Amyloid Pathology in the Aged Transgenic Mice with Alzheimer Presenilin 1 Mutation.” J Mol Neurosci. 34.2 (2008): 165-71.
  261. Ono K, et al. “Preformed Beta-Amyloid Fibrils Are Destabilized by Coenzyme Q10 in Vitro.” Biochem Biophys Res Commun. 330.1 (2005): 111-6.
  262. Gutzmann H, Kuhl KP, Hadler D, et al. Safety and Efficacy of Idebenone Versus Tacrine in Patients with Alzheimer's Disease: Results of a Randomized, Double-Blind, Parallel-Group Multicenter Study. [In eng] Pharmacopsychiatry. 2002 Jan; 35(1): 12-8.
  263. Gutzmann H, and Hadler D. Sustained Efficacy and Safety of Idebenone in the Treatment of Alzheimer's Disease: Update on a 2-Year Double-Blind Multicentre Study. [In eng] J Neural Transm Suppl. 1998 54(301-10.
  264. Senin U, Parnetti L, Barbagallo-Sangiorgi G, et al. Idebenone in Senile Dementia of Alzheimer Type: A Multicentre Study. [In eng] Arch Gerontol Geriatr. 1992 Nov-Dec; 15(3): 249-60.
  265. Forman HJ, et al. “Glutathione: Overview of its Protective Roles, Measurement, and Biosynthesis.” Mol Aspects Med. 30.1-2 (2009): 1-12.
  266. Arakawa M and Ito Y. “N-acetylcysteine and Neurodegenerative Diseases: Basic and Clinical Pharmacology.” Cerebellum. (2007):1-7. Epub ahead of print.
  267. Pocernich CB, et al. “In Vivo Glutathione Elevation Protects against Hydroxyl Free Radical-Induced Protein Oxidation in Rat Brain.” Neurochem Int. 36.3 (2000): 185-91.
  268. Crack PJ, et al. Lack of Glutathione Peroxidase-1 Exacerbates Abeta-Mediated Neurotoxicity in Cortical Neurons.” J Neural Transm 113.5 (2006): 645-57. Epub ahead of print October 21, 2005.
  269. Tchantchou F, et al. “N-Acetyl Cysteine Alleviates Oxidative Damage to Central Nervous System of Apoe-Deficient Mice Following Folate and Vitamin E-Deficiency.” J Alzheimers Dis. 7.2 (2005): 135-8.
  270. Ven Murthy MR, et al. “Scientific Basis for the Use of Indian Ayurvedic Medicinal Plants in the Treatment of Neurodegenerative Disorders: Ashwagandha.” Cent Nerv Syst Agents Med Chem. 10.3 (2010): 238-46.
  271. Sehgal N, Gupta A, Valli RK,et al. Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3510-5. Epub 2012 Jan 30.
  272. Kuboyama T, et al. “Neuritic Regeneration and Synaptic Reconstruction Induced by Withanolide A.” Br J Pharmacol. 144.7 (2005): 961-71.
  273. Choudhary MI, et al. “Cholinesterase Inhibiting Withanolides from Withania somnifera.” Chem Pharm Bull Tokyo. 52.11 (2004): 1358-61.
  274. Lau FC, et al. “The Beneficial Effects of Fruit Polyphenols on Brain Aging.” Neurobiol Aging. 26.1 (2005): 128-32.
  275. Casadesus G, Shukitt-Hale B, Stellwagen HM, et al. Nutr Neurosci. 7.5-6 (2004): 309-16.
  276. Wu X, et al. “Lipophilic and Hydrophilic Antioxidant Capacities of Common Foods in the United States.” J Agric Food Chem. 52.12 (2004b): 4026-37.
  277. Rezai-Zadeh K, et al. “Flavonoid-Mediated Presenilin-1 Phosphorylation Reduces Alzheimer’s Disease Beta-Amyloid Production.” J Cell Mol Med. 13.3 (2009): 574-88.
  278. Kristensen MO, Gulmann NC, Christensen JE, et al. Serum cobalamin and methylmalonic acid in Alzheimer dementia. Acta Neurol Scand. 1993 Jun;87(6):475-81.
  279. Jiménez-Jiménez FJ, et al. “Cerebrospinal Fluid Levels of Alpha-Tocopherol (Vitamin E) in Alzheimer’s Disease.” J Neural Transm. 104.6-7 (1997): 703-10.
  280. Bowman GL, et al. “Nutrient Biomarker Patterns, Cognitive Function, and MRI Measures of Brain Aging.” Neurology. [Epub ahead of print] December 28, 2011.
  281. Chan A, et al. “Efficacy of a Vitamin/Nutriceutical Formulation for Early-Stage Alzheimer’s Disease: A 1-Year, Open-Label Pilot Study with a 16-Month Caregiver Extension.” Am J Alzheimers Dis Other Demen. 23.6 (2008): 571-85.
  282. Haskell CF, et al. “Effects of a Multi-Vitamin/Mineral Supplement on Cognitive Function and Fatigue During Extended Multi-Tasking.” Hum Psychopharmacol. 25.6 (2010): 448-61.