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Life Extension Magazine

May 9, 2000


National Academy of Sciences References


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51. Foster CS, et al. Ascorbate therapy in impaired neutrophil and monocyte chemotaxis. With atopy, hyperimmunoglobulinemia E, and recurrent infection. Arch Ophthalmol 1978 Nov;96(11):2069-72.

52. Rebora A, et al. Repeated staphylococcal pyoderma in two siblings with defective neutrophil bacterial killing. Dermatologica 1980;160(2):106-12.

53. Patrone F, et al. Disorders of neutrophil function in children with recurrent pyogenic infections. Med Microbiol Immunol (Berl) 1982;171(2):113-22.

54. Patrone F, et al. Effects of ascorbic acid on neutrophil function. Studies on normal and chronic granulomatous disease neutrophils. Acta Vitaminol Enzymol 1982;4(1-2):163-8.

55. Rebora A, et al. Neutrophil dysfunction and repeated infections: influence of levamisole and ascorbic acid. Br J Dermatol 1980 Jan;102(1):49-56.

56. de la Fuente M, et al. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 1998 Apr;76(4):373-80.

57. Levy R, et al. Successful treatment of a patient with recurrent furunculosis by vitamin C: improvement of clinical course and of impaired neutrophil functions. Int J Dermatol 1993 Nov;32(11):832-4.

58. Anderson R. Ascorbate-mediated stimulation of neutrophil motility and lymphocyte transformation by inhibition of the peroxidase/H2O2/halide system in vitro and in vivo. Am J Clin Nutr 1981 Sep;34(9):1906-11.

59. Ferrandez MD, et al. Effects in vitro of several antioxidants on the natural killer function of aging mice. Exp Gerontol 1999 Aug;34(5):675-85.

60. Heuser G, et al. Enhancement of natural killer cell activity and T and B cell function by buffered vitamin C in patients exposed to toxic chemicals: the role of protein kinase-C. Immunopharmacol Immunotoxicol 1997 Aug;19(3):291-312.

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62. Ghorbani AJ, et al. Scurvy. J Am Acad Dermatol 1994 May;30(5 Pt 2):881-3.

63. Valkonen MM, et al. Vitamin C prevents the acute atherogenic effects of passive smoking. Free Radic Biol Med 2000 Feb 1;28(3):428-36.

64. Galley HF, et al. Combination oral antioxidant supplementation reduces blood pressure. Clin Sci (Colch) 1997 Apr;92(4):361-5.

65. Gokce N, et al.Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1999 Jun 29;99(25):3234-40.

66. Chambers JC, et al.Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin c therapy. Circulation 1999 Mar 9;99(9):1156-60.

67. Wilkinson IB, Megson IL, et al. Oral vitamin C reduces arterial stiffness and platelet aggregation in humans. J Cardiovasc Pharmacol 1999 Nov;34(5):690-3.

68. Jeserich M, et al. Vitamin C improves endothelial function of epicardial coronary arteries in patients with hypercholesterolaemia or essential hypertension--assessed by cold pressor testing. Eur Heart J 1999 Nov;20(22):1676-80.

69. Frei B . On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc Soc Exp Biol Med 1999 Dec;222(3):196-204.

70. Fuller CJ, et al. Effect of ascorbate supplementation on low density lipoprotein oxidation in smokers. Atherosclerosis 1996 Jan 26;119(2):139-50.

71. Kuusi T . Vitamin C prevents the acute atherogenic effects of passive smoking.Valkonen MM, Free Radic Biol Med 2000 Feb 1;28(3):428-36.

72. Zhang J, et al. A single high dose of vitamin C counteracts the acute negative effect on microcirculation induced by smoking a cigarette. Microvasc Res 1999 Nov;58(3):305-11.

73. Purkayastha SS, et al. Effect of vitamin C and E in modulating peripheral vascular response to local cold stimulus in man at high altitude. Jpn J Physiol 1999 Apr;49(2):159-67.

74. Chamiec T, et al.Effects of antioxidant vitamins C and E on signal-averaged electrocardiogram in acute myocardial infarction. Am J Cardiol 1996 Feb 1; 77(4):237-41.

75. Gatto LM, et al. Ascorbic acid induces a favorable lipoprotein profile in women. J Am Coll Nutr 1996 Apr;15(2):154-8.

76. Singh RB, et al . Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian experiment of infarct survival-3). Am J Cardiol 1996 Feb 1;77(4):232-6.

77. Munoz JA, et al . Effect of VITAMIN C on lipoproteins in healthy adults. Ann Med Interne (Paris) 1994;145(1):13-9.

78. Tomoda H, et al. Possible prevention of postangioplasty restenosis by Ascorbic acid. Am J Cardiol 1996 Dec 1;78(11):1284-6.

79. Laskowski H, et al. Mortality and clinical course of patients with acute myocardial infarction treated with streptokinase and antioxidants: mannitol and Ascorbic acid. Int J Cardiol 1995 Mar 3;48(3):235-7.

80. Eriksson J, et al. Magnesium and Ascorbic acid supplementation in diabetes mellitus. Ann Nutr Metab 1995;39(4):217-23.

81. Cerna O,et al.Plasma lipids, lipoproteins and atherogenic index in men and women administered vitamin c. Cor Vasa 1992;34(3):246-54.

82. Barta E, et al.Protective effect of alpha-tocopherol and L-ascorbic acid against the ischemic-reperfusion injury in patients during open-heart surgery. Bratisl Lek Listy 1991 Mar-Apr;92(3-4):174-83.

83. Salonen JT,et al. Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status. Am J Clin Nutr 1991 May;53(5):1222-9.

84. Mayer-Davis EJ, et al. Vitamin c intake and cardiovascular disease risk factors in persons with non-insulin-dependent diabetes mellitus. From the Insulin Resistanc Atherosclerosis Study and the San Luis Valley Diabetes Study. rev Med 1997 May-Jun;26(3):277-83.

85. Bostom AG, et al.The effect of high-dose ascorbate supplementation on plasma lipoprotein(a) levels in patients with premature coronary heart disease. Pharmacotherapy 1995 Jul-Aug;15(4):458-64.

86. Westhuyzen J, et al.Effect of preoperative supplementation with alpha-tocopherol and ascorbic acid on myocardial injury in patients undergoing cardiac operations. J Thorac Cardiovasc Surg 1997 May;113(5):942-8.

87. Tanaka H, et al.Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study. Arch Surg 2000 Mar;135(3):326-31.

88. Kodama N, et al. Cisternal irrigation therapy with urokinase and ascorbic acid for prevention of vasospasm after aneurysmal subarachnoid hemorrhage. Outcome in 217 patients. Surg Neurol 2000 Feb;53(2):110-7; discussion 117-8.

89. Sinclair S, et al. Male infertility: nutritional and environmental considerations. Altern Med Rev 2000 Feb;5(1):28-38.

90. van Rooij J, et al. Oral vitamins C and E as additional treatment in patients with acute anterior uveitis: a randomised double masked study in 145 patients. Br J Ophthalmol 1999 Nov;83(11):1277-82.

91. Zollinger PE, et al. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures:
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92. Gorton HC, et al. The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections. J Manipulative Physiol Ther 1999 Oct;22(8):530-3.

93. Vermeer IT, et al. Effect of ascorbic acid and green tea on endogenous formation of N-nitrosodimethylamine and N-nitrosopiperidine in humans. Mutat Res 1999 Jul 16;428(1-2):353-61.

94. Reinhold U, et al. Treatment of progressive pigmented purpura with oral bioflavonoids and ascorbic acid: an open pilot study in 3 patients. J Am Acad Dermatol 1999 Aug;41(2 Pt 1):207-8.

95. Hemila H. Vitamin C supplementation and common cold symptoms: factors affecting the magnitude of the benefit. Med Hypotheses 1999 Feb;52(2):171-8.

96. McAuliffe AV, et al. Administration of ascorbic acid and an aldose reductase inhibitor (tolrestat) in diabetes: effect on urinary albumin excretion. Nephron 1998 Nov;80(3):277-84.

97. de la Fuente M, et al. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 1998 Apr;76(4):373-80.

98. Allard JP, et al. Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects AIDS 1998 Sep 10;12(13):1653.

99. Eberlein-Konig B, et al. Phototoxic lysis of erythrocytes from humans is reduced after oral intake of Ascorbic acid and d-alpha-tocopherol. Photodermatol Photoimmunol Photomed 1997 Oct-Dec;13(5-6):173-7.

100. Alessio HM, et al.Exercise-induced oxidative stress before and after VITAMIN C supplementation. Int J Sport Nutr 1997 Mar;7(1):1-9.

101. Schwille PO, et al. Postprandial hyperinsulinaemia, insulin resistance and inappropriately high phosphaturia are features of younger males with idiopathic calcium urolithiasis: attenuation by Ascorbic acid supplementation of a test meal. Urol Res 1997;25(1):49-58.

102. Hemila H, et al. Vitamin C intake and susceptibility to the common cold. Br J Nutr 1997 Jan;77(1):59-72.

103. Gustafsson U, et al. The effect of VITAMIN C in high doses on plasma and biliary lipid composition in patients with cholesterol gallstones: prolongation of the nucleation time. Eur J Clin Invest 1997 May;27(5):387-91.

104. Jeng KC, et al.Supplementation with vitamins C and E enhances cytokine production by peripheral blood mononuclear cells in healthy adults. Am J Clin Nutr 1996 Dec;64(6):960-5.

105. McAlindon ME, et al. Effect of allopurinol, sulphasalazine, and VITAMIN C on aspirin induced gastroduodenal injury in human volunteers. Gut 1996 Apr;38(4):518-24.

106. Boffa MJ, et al. A double-blind, placebo-controlled, crossover trial of oral VITAMIN C in erythropoietic protoporphyria. Photodermatol Photoimmunol Photomed 1996 Feb;12(1):27-30.

107. Lonnrot K, et al. The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity. Free Radic Biol Med 1996;21(2):211-7.

108. Nadgrodkiewicz K , et al. [The effect of intravenous Ascorbic acid on urinary 17-hydroxysteroid excretion at an early stage of cerebral stroke]. Neurol Neurochir Pol 1996 Jan-Feb;30(1):49-56.

109. Wang H, et al. Experimental and clinical studies on the reduction of erythrocyte sorbitol-glucose ratios by Ascorbic acid in diabetes mellitus. Diabetes Res Clin Pract 1995 Apr;28(1):1-8.

110. Sharma DC, et al. .Correction of anemia and iron deficiency in vegetarians by administration of Ascorbic acid. Indian J Physiol Pharmacol 1995 Oct;39(4):403-6.

111. Paolisso G, et al. Metabolic benefits deriving from chronic VITAMIN C supplementation in aged non-insulin dependent diabetics. J Am Coll Nutr 1995 Aug;14(4):387-92.

112. Gastaldello K,et al.Resistance to erythropoietin in iron-overloaded haemodialysis patients can be overcome by Ascorbic acid administration. Nephrol Dial Transplant 1995;10 Suppl 6:44-7.

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115. Herbaczynska-Cedro K, et al. Inhibitory effect of vitamins C and E on the oxygen free radical production in human polymorphonuclear leucocytes. Eur J Clin Invest 1994 May;24(5):316-9.

116. Cunningham JJ, et al. VITAMIN C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus. J Am Coll Nutr 1994 Aug;13(4):344-50.

117. Kataoka A, et al. [Intermittent high-dose VITAMIN C therapy in patients with HTLV-I-associated myelopathy]. Rinsho Shinkeigaku 1993 Mar;33(3):282-8.

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119. Karduss Urueta A, et al. [Results of the treatment of chronic idiopathic thrombocytopenic purpura with Ascorbic acid]. Gac Med Mex 1993 Jan-Feb;129(1):23-5.

120. Dawson EB, et al. Effect of Ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril 1992 Nov;58(5):1034-9.

121. Triana Mantilla ME, et al. [The effect of VITAMIN C on the lipolytic activity in type-II diabetics with angiopathy]. [Article in Spanish] Angiologia 1991 Mar-Apr;43(2):77-81.

122. Reed PI, et al.Effect of Ascorbic acid on the intragastric environment in patients at increased risk of developing gastric cancer. IARC Sci Publ 1991;(105):139-42.

123. Beser E et al.The effects of short-term VITAMIN C on plasma bun, uric acid, cholesterol and triglyceride levels. Acta Med Hung 1991;48(1-2):73-8.

124. Bucca C, et al. Effect of VITAMIN C on histamine bronchial responsiveness of patients with allergic rhinitis. Ann Allergy 1990 Oct;65(4):311-4 Ann Allergy 1990 Oct;65(4):311-4.

125. Hunt JR, et al. Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women. Am J Clin Nutr 1990 Apr;51(4):649-55.

126. Mai J, et al. High dose antioxidant supplementation to MS patients. Effects on glutathione peroxidase, clinical safety, and absorption of selenium. Biol Trace Elem Res 1990 Feb;24(2):109-17.

127. Mirvish SS, et al. Effect of ascorbic acid dose taken with a meal on nitrosoproline excretion in subjects ingesting nitrate and proline. Nutr Cancer 1998;31(2):106-10.

128. Seven A, et al. Biochemical evaluation of oxidative stress in propylthiouracil treated hyperthyroid patients. Effects of vitamin C supplementation. Clin Chem Lab Med 1998 Oct;36(10):767-70.

129.Heuser G, et al. Enhancement of natural killer cell activity and T and B cell function by buffered VITAMIN C in patients exposed to toxic chemicals: the role of protein kinase-C. Immunopharmacol Immunotoxicol 1997 Aug;19(3):291-312.

130. Liyanage C, et al. Iron absorption from a traditional Sri Lankan weaning food and the enhancing effect of Ascorbic acid in adult male volunteers. Ceylon Med J 1996 Dec;41(4):135-40.

131. Hunt C, et al. The clinical effects of VITAMIN C
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132. Johnston CS, et al. Megadose of VITAMIN C delays insulin response to a glucose challenge in normoglycemic adults. Am J Clin Nutr 1994 Nov;60(5):735-8.

133. Bednar C, et al. Nitrate and VITAMIN C from fruits and vegetables: impact of intake variations on nitrate and nitrite excretions of humans. Plant Foods Hum Nutr 1994 Jan;45(1):71-80.

134. Levin ED, et al. Clinical trials using Ascorbic acid aerosol to aid smoking cessation. Drug Alcohol Depend 1993 Oct;33(3):211-23.

135.Maxwell SR, et al. Changes in plasma antioxidant status during eccentric exercise and the effect of vitamin supplementation. Free Radic Res Commun 1993;19(3):191-202 .