Life Extension Magazine April 2003
Silicon: An Overlooked
Bioavailability and efficacy of silicon supplements
When selecting a silicon supplement, the most important considerations should be safety and bioavailability. (Bioavailability is a complex term for the degree of absorption and the biological response to the silicon compounds which are present in the product.) Organic silicon compounds, which are laboratory synthesized, contain silicon-carbon bonds. These molecules are normally not present in biological systems and can be very toxic. For this reason it is safest to use silicon compounds that are already present in nature or compounds that are the derivatives of natural products. Common silicon supplements include:
Bamboo and algae usually have high silica concentrations. However, plant extracts are often not standardized and the silicon concentration in these products varies greatly. As the silicon from plant extracts cannot be absorbed directly through the stomach wall, the bioavailability of these products requires high stomach acidity in order to produce soluble orthosilicic acid.
Colloidal silicon gel:
These products offer large, insoluble, polymer molecules of silicic acid suspended in water. Like plant extracts, these polymer-molecules cannot be absorbed directly through the stomach wall and therefore have a low rate of absorption. The stomach's ability to produce soluble orthosilicic acid is also limited to low concentration levels due to orthosilicic acid's limited stability.
Stabilized orthosilicic acid:
Now on the market is a liquid, stabilized orthosilicic acid concentrate. A research group from the University of Antwerp in Belgium has published a supplementation study describing a high rate of silicon absorption from a liquid silicon supplement containing 2% silicon in the form of stabilized orthosilicic acid. In the six-month study with calves, the total dietary silicon intake was increased by only 5% in the form of stabilized orthosilicic acid. Even with such a small dose of orthosilicic acid, the supplemented group showed 70% higher blood silicon levels than the unsupplemented group. These higher silicon blood levels also translated into a 12% higher collagen concentration in the skin of supplemented animals compared to unsupplemented animals. This study clearly demonstrated that the bioavailability of stabilized orthosilicic acid concentrate is very high compared to dietary silicon.19
Two independent Belgian research groups demonstrated both in a comparative human study that the total silicon absorption by the human body is considerably higher (more than 2.5 times higher) after supplementation of stabilized orthosilicic acid (as present in a product called BioSilTM) compared to plant extracts or colloidal supplements. In fact, only BioSilTM supplementation resulted in a statistical significant increase in silicon absorption compared to the placebo. Without exception, each test subject had a similar absorption from orthosilicic acid, whereas large differences among subjects were found for the other silicon supplements.20,21
The bone stimulatory properties of silicon was recently investigated in an extended study on chicks. For the first time a normal diet was used instead of silicon deficient diet, which made it possible to observe the superior biological action of silicon in supplemented chicks compared to a control group. The silicon was added to the drinking water of the chicks, which increased the total dietary silicon intake less than 0.5%. Despite this extremely low dose a significant effect was found on both the calcium concentration in the blood and the density of thigh bones (femura).
In fact, the chicks had, after six weeks supplementation, 5.6% higher bone density in the hip region and 4.25% higher bone density at the midshaft of their thigh bones compared to non-supplemental chicks. These results show clearly that stabilized silicon (choline-silicon complex) was able to stimulate the bone formation machinery resulting in a higher density.22
Based on all the current research, silicon is now being considered a critical nutrient to better manage the effects of age on the body. Increasing the silicon in your body can occur through foods, plant extracts or supplements. Those with osteoporosis should especially consider the benefits of consistent silicon intake.
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