Life Extension Magazine October 2004
Cosmetics that Protect and Enhance the Health of the Skin
|LE Magazine October 2004|
|Cosmetics that Protect and Enhance the Health of the Skin|
At an early age, women begin applying makeup to their faces. The cosmetics are usually put on in the morning, re-applied throughout the day, and then taken off only at bedtime. As women grow older, they often saturate their faces with heavier layers of makeup. As a result, most women spend the majority of their lives wearing cosmetics.
This begs the question of whether this constant exposure to cosmetic preparations is healthy for the skin. A look at the ingredients in commercial cosmetic products reveals that they provide little in the way of beneficial effects. It would seem logical that if a woman is going to wear cosmetics to enhance her appearance, the ingredients in those cosmetics should at least help improve the health of her skin.
Sadly, the $45 billion-a-year cosmetic industry has overlooked the obvious—the desirability of including validated anti-aging ingredients in cosmetic preparations. An ideal cosmetic would incorporate nutrients that have been shown to protect and improve the skin’s appearance. This would provide significant benefit to the tens of millions of women who wear makeup every day.
Recognizing the deficiencies in commercial makeup products, the Life Extension Buyers Club has identified a cosmetic company that includes in its products ingredients that protect against age-accelerating environmental factors and provide nutrients that have been shown to partially reverse some aspects of skin aging.
Wrinkles, dryness, sagging, and irregular pigmentation characterize aging skin. Yet scientific studies have identified nutrients that can slow and even partially reverse these unsightly outward effects.1
Sun exposure, for instance, is a major cause of skin aging and skin cancer. Photodamage is characterized by the formation of damaging free radicals. Photoradiation depletes the body’s natural antioxidant systems and increases the destructive modification of proteins in a process known as glycation. These pathological effects can be seen in the upper and lower layers of the skin.
Glycated proteins result in the stiffening, wrinkling, and unsightly leathery appearance of aging skin.2 Collagen degradation induced by ultraviolet light causes a breakdown of the skin’s structural support system, resulting in skin sagging, distortion, and excessive wrinkling.
Women concerned about the health of their skin try to avoid prolonged exposure to the sun. The unfortunate fact is that normal, everyday sun exposure causes cumulative damage that results in premature aging. Sun exposure not only accelerates aging, but also increases skin cancer risk. A dermatology researcher described the multiple pathological effects of sunlight and concluded his study by stating:
“. . . everyday use of products that protect against UV radiation is necessary to prevent acute and long-term photodamage (clinical and cellular changes) leading to photoaging, photoimmunosuppression, and photocarcinogenesis.”3
Considering the deleterious effects that ultraviolet light inflicts on the face, it makes perfect sense to fortify lipsticks and foundations to guard these facial areas against destructive ultraviolet rays. Some women pay dermatologists thousands of dollars for collagen injections in their lips and faces, yet neglect to protect their own precious natural collagen against destructive solar rays. Now there are cosmetic products available that provide sun-blocking agents to guard the lips, cheeks, forehead, nose, and other parts of the face. These new cosmetics also provide nutrients that help rejuvenate collagen.
Applying Green Tea Extract
In a study published in the prestigious journal Proceedings of the National Academy of Sciences USA, hairless mice were irradiated with ultraviolet B (UVB) light twice weekly for 20 weeks.4 Their exposure to UVB meant that these mice had a high risk of developing skin cancers. The mice were then treated topically with green tea extract after the UVB exposure (once a day, five days a week, for 18 weeks).
The study results showed that topical applications of green tea extract decreased the number of nonmalignant tumors by 55% and reduced the number of malignant tumors by 65%. Cellular analysis showed that topically applied green tea extract significantly increased apoptosis (cell death) in tumor cells, but did not have an apoptotic effect in healthy cells. Significantly, this study clearly demonstrated that green tea extract can inhibit the development of skin cancer after long-term exposure to UVB light.4
Green tea extract possesses antioxidant, anti-inflammatory, and anticarcinogenic properties. Studies of human skin have demonstrated that green tea prevents ultraviolet-induced damage that leads to immune suppression and skin cancer induction. Treating human skin with green tea extract prevents penetration of UVB radiation. Scientists have published research indicating that green tea prevents the DNA skin damage, inflammation, and immune suppression that result from UVB exposure.5
Scientists believe that due to its antimutagenic and antitumor activities, green tea extract is a promising candidate for use in topical formulations for skin cancer prevention.6
When skin is exposed to ultraviolet light, inflammation-inducing leukocytes infiltrate the skin, immune cells are depleted, and oxidative damage occurs. A group of scientists pretreated the skin of mice with green tea extract in order to define how this might protect against immune suppression and cancer. Topical green tea application before a single dose of UVB exposure inhibited the expected infiltration of leukocytes into the skin. Green tea also prevented UVB-induced depletion of the number of antigen-presenting cells in the immune system. As far as oxidation is concerned, green tea protected against UVB-induced hydrogen peroxide and nitric oxide free-radical damage in both the epidermis and dermis. The scientists concluded that green tea might be effective in preventing solar-induced skin cancers and immune suppression.7,8
While the anticancer potential of green tea is well established, the effects of green tea on normal skin aging processes are also of significant interest. Scientists conducted a study investigating the effects of green tea extract on healthy skin cell proliferation and UV-induced cell death. When topically applied to aged human skin, green tea extract stimulated the proliferation of structure-supporting skin cells (keratinocytes), which increased the epidermal thickness of the skin. In addition, this topical application inhibited the UV-induced destruction of keratinocytes. Aging is characterized by thinning skin and destruction of skin cells. This study showed that topical application of green tea extract improved these two molecular parameters of skin aging.9
Free radicals cause tremendous damage to the skin and are a major causative factor in skin aging. In a study that measured antioxidant levels in the skin, green tea extract was topically administered to hairless mice that were then exposed to UVB light. The results showed a substantial reduction in the depletion of natural antioxidants normally induced by UVB light. Topical green tea prevented the reduction of glutathione by 87-100%, of glutathione peroxidase by 78-100%, and of catalase by 51-92%. Topical treatment with green tea extract also inhibited oxidative stress when measured in terms of lipid peroxidation (a 76-95% reduction) and protein oxidation (a 67-75% reduction). Molecular measurement of skin-aging damage showed that significant protective effects were conferred by the green tea. The scientists next added green tea extract to the drinking water of these mice and observed similar antioxidant benefits to the skin, though comparatively less than when green tea extract was applied topically.10
In another study of hairless mice, scientists applied green tea extract before UVB exposure. These treatments were repeated every other day for two weeks, for a total of seven treatments. Topical application of green tea extract significantly decreased UVB-induced bifold-skin thickness, skin edema, and infiltration of leukocytes. Using molecular measuring tests, the scientists determined that green tea suppressed the damaging effects of UVB and the subsequent inflammatory cascade by several well-defined mechanisms.11 This study corroborates other findings indicating that topically applied green tea extract may protect against accelerated skin aging.
Why Skin Cancer Protection Is Critical
When skin cancer develops, the face can be scarred with long-lasting, unsightly surgical lesions. Exposure to everyday solar rays is the major causative factor for face cancers and skin aging. Taking steps to protect your face every day from destructive UVB rays is mainstream medicine’s most highly recommended anti-aging technique.
The antiaging cosmetics that are now available contain extracts from green, white, and red teas, along with potent sun-blocking agents that have high sun-protection-factor (SPF) ratings to protect the lips and facial skin. Preliminary studies of white and red teas indicate that they may possess anti-aging properties even greater than those of green tea.12
How Vitamin C May Reverse Skin Aging
In a double-blind human study, topical vitamin C was applied to one-half of the face and a placebo gel was applied to the other side. Clinical evaluation of wrinkling, pigmentation, inflammation, and hydration was performed prior to the study and at weeks 4, 8, and 12. The results showed a statistically significant improvement of the side treated with vitamin C, with decreased photoaging scores of the cheeks and the periorbital area. The periorbital area improved in both the vitamin C and placebo-gel group, likely indicating improved hydration. The overall facial improvement of the vitamin C side was statistically significant. Biopsies showed increased collagen formation in the vitamin C group. This study showed that topically applied vitamin C results in clinically visible and statistically significant improvement in wrinkling when used for 12 weeks. This clinical improvement correlated with biopsy evidence of new collagen formation.13
Human studies have demonstrated pronounced protective effects of antioxidants when applied topically before ultraviolet radiation exposure. With respect to UVB-induced skin damage, the photoprotective effects of antioxidants are significant. Topical application of antioxidant combinations may result in a sustained capacity of the skin to resist damaging free radicals, possibly due to antioxidant synergisms.
Free radicals are a culprit behind UVA-induced skin alterations, thus providing a scientific basis for topical antioxidant administration. In a human study, topical application of antioxidants resulted in diminished severity of UVA-induced sun damage. Thus, regular application of skin care products containing antioxidants such as vitamins C and E may be of the utmost benefit in protecting skin against the exogenous oxidative stressors encountered in daily life. Sunscreen agents may also benefit from being combined with antioxidants, as both the safety and efficacy of the sun-blocking products are enhanced.14
Collagen is the chief constituent of the connective tissue that supports the skin’s structure. The skin requires constant synthesis of new collagen to remain firm and youthful. Epidemiological studies strongly indicate an association between tobacco smoking and skin aging. One study showed that collagen biosynthesis was reduced by 40% following treatment with tobacco smoke extract. When an antioxidant mixture that included vitamins C and E was applied, the destructive alteration of collagen induced by both tobacco and UVA radiation was prevented.15
A randomized, double-blind controlled study was conducted on human volunteers to determine the efficacy of topical vitamin C application in treating mild to moderate photodamage of facial skin. Methods of evaluating efficacy included an objective computer-assisted image analysis of skin surface topography, as well as subjective clinical, photographic, and patient self-appraisal questionnaires. Topical vitamin C was applied to one side of each patient’s face and a placebo was applied to the other side for three months.
The results using the optical image analysis demonstrated that compared to placebo, the side treated with vitamin C showed a statistically significant 71% combined score improvement. Clinical assessment parameters demonstrated significant improvement with vitamin C treatment compared to placebo for fine wrinkling, tactile roughness, coarse rhytids, skin laxity/tone, sallowness/yellowing, and overall features. Patient questionnaire results demonstrated statistically significant improvement overall, with the vitamin C treatment scoring 84% greater than placebo. Photographic assessment demonstrated significant improvement as well, with the vitamin C treatment scoring 58% greater than placebo. This three-month study using topical vitamin C provided objective and subjective improvement in photodamaged facial skin.16