Life Extension Magazine April 2004
A Partial Reversal of Skin Aging
|LE Magazine April 2004|
|A Partial Reversal of Skin Aging|
A new delivery system overcomes a long-standing obstacle to effective skin care
A Multipronged Attack on Skin Aging
Collagen is a naturally occurring protein that provides support and flexibility to the skin. It forms a mesh-like structure that supports new cells as they grow. Collagen levels diminish with age, resulting in skin sagging, loosening, and losing resiliency. When collagen is injected into the skin, it increases the supportive layer under the skin so that scars, lines, and winkles can be filled in. As a result, skin looks younger and smoother.
Cosmetics companies have taken advantage of the known benefits of collagen injections to claim that their collagen creams produce similar anti-aging effects. Regrettably, collagen molecules are too large to efficiently pass through the upper layer of the skin, so collagen creams provide little benefit.
For the first time, a patent-pending delivery system has been developed that enables very large molecules (such as collagen) to pass through the upper layer of skin. When this new transdermal system is combined with collagen, the collagen molecules are delivered directly to the third layer of the epidermis—an effect achieved previously only by injection.
Collagen replacement is one important component of an anti-aging skin program. The good news is that scientists have published findings indicating that people may have more control over the rate at which their skin ages than over any other organ of the body.
To slow skin aging and partially reverse it, an individual must take a comprehensive approach to gaining control over all the factors that have been identified in the skin degeneration process. Life Extension members have taken advantage of this wealth of knowledge by using the multi-ingredient Rejuvenex® and/or Dream Cream® face creams. Both of these formulas contain stabilized forms of vitamin C, which has been shown in published studies to facilitate the natural synthesis of collagen beneath the skin and induce anti-aging effects.
With the availability of Hydroderm® liquid drops, far more collagen can now be restored beneath aging skin. For optimal results, we suggest applying Hydroderm® liquid drops immediately after the face is cleansed while the pores are open for maximum assimilation of the collagen into the lower layers of the skin. Wait 15 minutes for the Hydroderm® to dry, and then apply Rejuvenex® or Dream Cream® to provide your skin with a complete armamentarium of age-defying nutrients.
Taking Control of Your Appearance
While the concept of controlling cellular aging remains controversial, no one disagrees that individuals can significantly influence the rate at which their skin ages. For instance, if a person wants to accelerate skin degradation, all they have to do is expose themselves to lots of ultraviolet radiation, cigarette smoke, and ethanol. Even second-hand cigarette smoke prematurely ages the skin.
Hydroderm® liquid drops have become an incredible success story. Word-of-mouth advertising has resulted in an enormous number of jars being shipped monthly to regular users. Based on our review of the scientific reports and the results of our own clinical study, Hydroderm® has demonstrated efficacy in reversing the signs of certain aspects of skin aging, primarily in people over the age of 40.
1. Gilchrest BA. Skin aging 2003: Recent advances and current concepts. Cutis. 2003;72:S5-S10.
2. Chung JH, Seo JY, Choi HR, et al. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dematol. 2001 Nov;117(5):1218-24.
3. Leveque N, Robin S, Makki S, Muret P, Rougier A, Humbert P. Iron and ascorbic acid concentrations in human dermis with regard to age and body sites. Gerontology. 2003 Mar-Apr;49(2):117-22.
4. Nusgens BV, Humbert P, Rougier A, et al. Topically applied vitamin C enhances the mRNA level of collagens I and III, their pro- cessing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis. J Invest Dermatol. 2001 Jun;116(6):853-9.
5. Zhang L, Lerner S, Rustrum WV, Hofmann GA. Electroporation-mediated topical deliv- ery of vitamin C for cosmetic applications. Bioelectrochem Bioenerg. 1999 May;48(2):453-61.
6. Narasimhan B. Mathematical models describing polymer dissolution: consquences for drug delivery. Adv Drug Deliv Rev. 2001 Jun 11;48(203):195-210.
7. Moser K, Kriwet K, Kalia YN, Guy RH. Enhanced skin permeation of a lipophilic drug using supersaturated formulations. J Control Release. 2001 Jun 15;73(2-3):245-53.
8. Moragas A, Garcia-Bonafe M, Sans M, Toran N, Huguet P, Martin-Plata C. Image analysis of dermal collagen changes during skin aging. Anal Quant Cytol Histol. 1998 Dec;20:493-9.
9. Labat-Robert J, Robert L. Aging of the extracellular matrix and its pathology. Exp Gerontol. 1988;23(1):5-18.
10. Yaar M, Eller MS, Gilchrest BA. Fifty years of skin aging. J Investig Dermatol Symp Proc. 2002 Dec;7(1):51-8.
11. Balin AK, Pratt LA. Physiological con- squences of human skin aging. Cutis. 1989 May;43(5):431-6.
12. Kurban RS, Bhawan J. Histologic changes in skin associated with aging. J Dermatol Surg Oncol. 1990 Oct;16(10):908-14.
13. Yamauchi M, Woodley DT, Mechanic GL. Aging and cross-linking of skin collagen. Biochem Biophys Res Commun. 1998 Apr 29;152(2):898-903.
14. Uitto J. Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. Clin Geriatr Med. 1989 Feb;5(1):127-47.
15. Giacomoni PU, Rein G. Factors of skin age- ing share common mechanisms. Biogerontology. 2001;2(4):219-29.
16. Tanaka S, Avigad G, Brodsky B, Eikenberyy EF. Glycation induces expansion of the molecular packing collagen. J Mol Biol. 1998 Sep 20;203(2):495-505.
17. Tsilibary EC, Charonis AS, Reger LA, Wohlhueter RM, Furcht LT. The effect of non-enzymatic glycosylation on the binding of the non-collagenousd NC1 domain to col- lagen IV. J Biol Chem. 1988 Mar 25;263(9):4302-8.
18. Vazquez F, Palacios S, Aleman N, Guerrero F. Changes of the basement membrane and type IV collagen in human skin during aging. Maturitas. 1996 Nov;25(3):209-15.
19. Vaillant L, Callens A. Hormone replacement treatment and skin aging. Therapie. 1996 Jan-Feb;51(1):67-70.
20. Purba MB, Kouris-Blazos A, Wattanapenpaiboon N, et al. Can skin wrin- kling in a site that has received limited sun exposure be used as a marker of health status and biological age? Age Ageing. 2001 May;30(3):227-34.
21. Baulieu EE, Thomas G, Legrain S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci. U S A. 2000 Apr 11;97(8):4279-84.
22. Campisi J. The role of cellular senescence in skin aging. Jinvestig Dermatol Symp Proc. 1998 Aug;3(1):1-5.
23. Fisher GJ, Kang S, Varani J, et al. Mechanisms of photoaging and chronologi- cal skin aging. Arch Dermol. 2002 Nov;138(11):1462.70.