Life Extension Magazine June 2004
Recharge With Pregnenolone
By Dave Tuttle
|LE Magazine June 2004|
|Recharge With Pregnenolone |
This little-known hormone fights fatigue, boosts memory, and more.
By Dave Tuttle
While human studies of pregnenolone supplementation have not been completed, compelling evidence suggests that pregnenolone plays a role in depression. In a study of 27 patients with depression and 10 healthy volunteers, the depressed subjects had lower levels of pregnenolone in their cerebrospinal fluid than the healthy individuals.13 Cerebrospinal fluid circulates in the spinal column and brain, indicating that the brains of the depressed patients were exposed to less pregnenolone than those of the healthy subjects. In another study that matched 12 healthy controls with 12 men who had generalized social phobia and were not taking medication, concentrations of pregnenolone sulfate were significantly lower in the plasma of the patients with social phobia, again implying that pregnenolone plays a role in mood states.14
Help for Spinal Cord Injuries
Researchers gave pregnenolone, indomethacin (an anti-inflammatory substance), and bacterial lipopolysaccharide (a stimulator of cytokine secretion) to rats both individually and in combination for 21 days. While the use of indomethacin and lipopolysaccharide eased the histopathological damage to some extent, there was little recovery of motor function. Adding pregnenolone to the mix produced a striking reduction in histopathological damage, and the tissue was spared from secondary injury (a common occurrence with spinalcord victims when the components of the inflammatory response become destructive). This three-way combination worked so well that 11 of the 16 animals were able to stand and walk after 21 days, four of them almost normally. The survival rate improved as well, possibly due to the protection that pregnenolone offered against the toxic effects of the other two drugs. Pregnenolone also increased the vascularization of the spared tissue and made the cellular matrix denser, while reducing the extent to which cavities formed on the injured tissue.
The researchers concluded that pregnenolone facilitated recovery by giving rise to the greatest number of other hormones, which are known to assist with coordinative processes within and between the neural, metabolic, and immune systems. Because of its dual action in inhibiting GABA release and boosting glutamate levels, pregnenolone can “exert remarkable synergistic amplification of excitatory transmission,”15 triggering the cascade of reactions needed for cell recovery.
Pregnenolone holds great promise in helping accident and trauma victims recover from their injuries. While the extent of benefit still must be quantified, it seems clear that the cascade of reactions produced by pregnenolone may be valuable in addressing a variety of medical conditions.
Benefits for Rheumatoid Arthritis
A number of studies have confirmed that pregnenolone has dramatic anti-arthritic effects, though the daily oral dosage required—approximately 500 mg—is significantly more than the dose needed to realize mental improvements.4 Pregnenolone is most helpful in the initial stages of arthritis before the pathological process has progressed too far. Moreover, a comparative study of cortisone and pregnenolone found that improvements lasted longer after the study ended when pregnenolone was administered. Because cortisone has several negative side effects, concurrent use with pregnenolone should permit a reduction in the cortisone dosage, helping to reduce the suffering of persons with rheumatoid arthritis. More research is needed, however, to determine the ideal combination dosage. Unfortunately, pregnenolone is not beneficial for osteoarthritis, a condition in which little inflammation exists.
By its very nature, pregnenolone works with your body to achieve optimal health and longevity. Pregnenolone’s many functions underscore its role as one of the most important hormones in the human body. Pregnenolone reduces fatigue and increases endurance. It also provides the brain with the hormonal and neurotransmitter support it needs to retard memory loss, thus helping to improve concentration and focus. Moreover, it helps those with arthritis, depression, and traumatic injuries.
Although pregnenolone has long been overlooked because it is “upstream” on the hormone pathway, its many benefits to human health suggest that this vital hormone has just begun to receive the attention it so richly deserves.
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