Life Extension Magazine August 2004
|LE Magazine August 2004|
A Potent Antioxidant that Protects Against Harmful Toxins
By Stephen Laifer
Entering the twenty-first century, one of our greatest health threats is pollutants. Uncounted toxic chemicals pollute what we eat, drink, and breathe. The battle against toxins is largely waged in the liver. Despite being the largest glandular organ, the liver still bears a disproportionate burden in ridding the body of toxins. Those pollutants that cannot be processed and disposed of are stored in fatty tissues, first in the liver and then in other parts of the body. Over time, this can cause long-term harm to the liver.
A Powerful Antioxidant
Research indicates that in addition to providing toxin protection, N-acetylcysteine is a selective immune system enhancer, improving symptoms and preventing recurrences of common lung-related illnesses such as chronic bronchitis.1 N-acetylcysteine may further protect lung tissue against other conditions through its antioxidant activity.2
Among the most damaging pollutants in the human body are reactive oxygen intermediates. More commonly called “free radicals,” these are the toxic waste products of normal cellular metabolism. Left unchecked, free radicals interrupt the cellular regenerative process, eventually damaging cells. Free-radical-mediated mechanisms have also been suggested as contributing to the development of several neurodegenerative diseases,3,4 and are even suspected of being a major factor in the body’s aging process.
Antioxidants scavenge free radicals, effectively neutralizing them and contributing to more-efficient liver function. Antioxidants may also improve food quality and stability by inhibiting the free radical oxidation of food during its processing and storage.5 N-acetylcysteine is a vital antioxidant whose demonstrated beneficial characteristics include the scavenging of potent hydroxyl radicals and diminished production of hydrogen peroxide (H2O2).6
Effects on Glutathione
Intracellular glutathione levels affect the ability of lung phagocytes—white blood cells that ingest and destroy bacteria and cellular debris—to do their job properly. Glutathione’s ability to scavenge free radicals enhances cellular function while helping the liver remove chemicals (such as drugs and pollutants) that are foreign to the body.
Glutathione is often considered the body’s most important antioxidant because of its location within the cell, which enhances its ability to neutralize free radicals. Increased glutathione levels have demonstrated particularly positive effects on those with severely depleted immune systems, such as HIV patients.7,8 Normal glutathione levels also show promise in the treatment of several lung disorders.9
More recently, patients with other neurodegenerative conditions including amyotrophic lateral sclerosis, multiple sclerosis, diabetic neuropathy, and Alzheimer’s disease have been treated with N-acetylcysteine. These treatment outcomes indicate that if improvement in antioxidant status occurs, the potential exists for arresting progression of the disease and, in some cases, even improving the sufferer’s condition. N-acetylcysteine, with its proven safety and various antioxidant capabilities, may be a promising new tool in the treatment of such disorders.
Benefits for the Kidney and Liver
Oral supplementation with N-acetylcysteine has even been used successfully in two cases to treat a rare syndrome known as pseudoporphyria that complicates kidney dialysis.13 The condition has no other known treatment.
The antioxidant activity of N-acetylcysteine helps protect the liver from potentially adverse effects of exposure to a broad range of toxic chemicals, including those chemicals that can poison the body through cumulative use. For example, N-acetylcysteine counteracts acetaminophen toxicity and has been routinely used at very high levels in hospitals for patients with acetaminophen poisoning. It has also been shown to be effective in treating liver failure from causes other than acetaminophen poisoning, including hepatitis and other drug toxicity.14
N-acetylcysteine has no demonstrated sedative or stimulant effects, and tolerance is excellent for the vast majority of people who take it regularly. As a potentially powerful antidote to our polluted environment, N-acetylcysteine is a simple yet profound way to help protect the body against the ravages of the modern industrialized world.
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