Life Extension Magazine September 2004
Magnesium in Hypertension Prevention and Control
By Jay S. Cohen, MD
|LE Magazine September 2004|
| Magnesium in Hypertension Prevention and Control |
By Jay S. Cohen, MD
Should You Take Magnesium?
Many people think they get enough magnesium from their multivitamins, but the amount of magnesium in many supplements is inadequate. It is recommended that you start with a low dose of magnesium such as 100 mg taken twice daily with meals, then gradually increase the dose to the RDA. For older people, whose kidney excretion of magnesium is reduced, 100-200 mg per day of magnesium is often sufficient.
People with magnesium deficiencies or hypertension may need even higher daily doses of magnesium. Some integrative practitioners use 600-800 mg per day of magnesium. Magnesium is usually well tolerated in people with normal kidney function, but you should always consult with a health care professional if you are taking more than the RDA. Symptoms of magnesium toxicity are rare and include weakness, slowed heart rate, reduced tendon reflexes, and somnolence.
If you require medications for high blood pressure, take them as your doctor suggests. For those with borderline or Stage 1 hypertension, however, natural methods can be tried first. If you have done this and your blood pressure is still elevated, see your doctor and inquire about medications that can help. The best way to avoid medication side effects is to use the very lowest dose required to bring your blood pressure down.31,32
Magnesium can be used in concert with drugs for hypertension. A friend of mine, an advanced yoga instructor, developed muscle tightness as a side effect of her antihypertensive medication. Supplementing with magnesium allowed her to reduce her medication dose, and her muscle tightness went away.
Of course, the best way to avoid medication side effects is to prevent hypertension from developing in the first place. If you do not have high blood pressure yet, now is the time to initiate preventive measures. Start with lifestyle strategies, including a healthy diet, regular exercise, stress reduction, and avoiding smoking, caffeinated beverages, and chemicals that raise blood pressure. Then make sure that you are getting enough potassium and magnesium, as well as other nutrients known to help control blood pressure.
If your blood pressure is already on the rise, do not hesitate to take action. By the time hypertension is apparent, your arteries have sustained years of injury; damage has already occurred and will continue to accelerate. High blood pressure is a killer, and often more destructive than high cholesterol. Do not wait for your doctor’s instruction—you can start taking steps to prevent hypertension today.
Jay S. Cohen, MD, is the author of OverDose, published by Tarcher/Putnam.
1. Brody JE. Hard facts of hypertension elude too many. New York Times. June 25, 2004.
2. Kaplan NM. Hypertension in the population at large. In: Clinical Hypertension. Baltimore, MD: Williams and Wilkins; 1998.
3. Rakel RE. Conn’s Current Therapy. Philadelphia, PA: WB Saunders Company; 1993.
4. Sixth report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med. 1997 Nov 24;157(21):2413-46.
5. Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003 Dec;42(6):1206-52. Epub 2003 Dec 01.
6. Appel LJ, Moore TJ, Obarzanek E, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997 Apr 17;336(16):1117-24.
7. Bloom BS. Daily regimen and compliance with treatment. BMJ. 2001 Sep 22;323(7314):647.
8. Reyes AJ, Alcocer, L. Minding magnesium while treating essential hypertension with diuretics. In: Theophanides T, Anastassopoulou J. Magnesium: Current Status and New Developments: Theoretical, Biological, and Medical Aspects. 1st ed. Dordrecht, Netherlands: Kluwer Academic Publishers; 1997.
9. Sheehan JP, Seelig MS. Interactions of magnesium and potassium in the pathogenesis of cardiovascular disease. Magnesium. 1984;3(46):30114.
10. Facts About Dietary Supplements (2001). NIH Clinical Center, National Institutes of Health. March 2001.
11. Rude RK. Magnesium deficiency: a cause of heterogeneous disease in humans. J Bone Miner Res. 1998 Apr;13(4):749-58.
12. Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons; 1996.
13. Cohen JS. High-dose oral magnesium in the treatment of chronic, intractable erythromelalgia. Ann Pharmacother. 2002 Feb;36(2):255-60.
14. Iseri LT, French JH. Magnesium: nature’s physiologic calcium blocker. Am Heart J. 1984 Jul;108(1):18893.
15. Leppert J, Myrdal U, Hedner T, Edvinsson L, Tracz Z, Ringqvist I. Effect of magnesium sulfate infusion on circulating levels of noradrenaline and neuropeptide-Y-like immunoreactivity in patients with primary Raynaud’s phenomenon. Angiology. 1994 Jul;45(7):637-45.
16. Latner AW. 34th annual top 200 drugs. Pharmacy Times. April 1999.
17. Cohen JS. OverDose: The Case Against the Drug Companies. New York, NY: Tarcher/Putnam; 2001.
18. Rogers SA. Tired or Toxic? A Blueprint for Health. Syracuse, NY: Prestige Publishing; 1990.
19. Altura BM, Altura BT. Magnesium in cardiovascular biology. Scientific American Science & Medicine. May/June 1995:28-37.
20. Altura BM, Altura BT. Role of magnesium in the pathogenesis of hypertension updated: relationship to its actions on cardiac, vascular smooth muscle, and endothelial cells. In: Laragh JH, Brenner BM, eds. Hypertension: Pathophysiology, Diagnosis, and Management. 2nd ed. New York, NY: Raven Press; 1995.
21. Motoyama T, Sano H, Fukuzaki H. Oral magnesium supplementation in patients with essential hypertension. Hypertension. 1989 Mar;13(3):22732.
22. Widman L, Wester PO, Stegmayr BK, Wirell M. The dosedependent reduction in blood pressure through administration of magnesium. A double-blind placebo-controlled crossover study. Am J Hypertens. 1993 Jan;6(1):41-5.
23. Sanjuliani AF, de Abreu Fagundes VG, Francischetti EA. Effects of magnesium on blood pressure and intracellular ion levels of Brazilian hypertensive patients. Int J Cardiol. 1996 Oct 11;56(2):177-83.
24. Itoh K, Kawasaka T, Nakamura M. The effects of high oral magnesium supplementation on blood pressure, serum lipids and related variables in apparently healthy Japanese subjects. Br J Nutr. 1997 Nov;78(5):737-50.
25. Kawano Y, Matsuoka H, Takishita S, Omae T. Effects of magnesium supplementation in hypertensive patients: assessment by office, home, and ambulatory blood pressures. Hypertension. 1998 Aug;32(2):2605.
26. Dyckner T, Wester PO. Effect of magnesium on blood pressure. Br Med J (Clin Res Ed). 1983 Jun 11;286(6381):1847-9.
27. Witteman JC, Grobbee DE, Derkx FH, Bouillon R, de Bruijn AM, Hofman A. Reduction of blood pressure with oral mag- nesium supplementation in women with mild to moderate hypertension. Am J Clin Nutr. 1994 Jul;60(1):129-35.
28. Seelig MS, Rosanoff A. The Magnesium Factor. New York, NY: Avery Publishers; 2003.
29. Johnson S. The multifaceted and widespread pathology of magnesium deficiency. Med Hypotheses. 2001 Feb;56(2):16370.
30. Galan P, Preziosi P, Durlach V, et al. Dietary magnesium intake in a French adult popula- tion. In: Theophanides T, Anastassopoulou J. Magnesium: Current Status and New Developments: Theoretical, Biological, and Medical Aspects. 1st ed. Dordrecht, Netherlands: Kluwer Academic Publishers; 1997.
31. Cohen JS. Dose discrepancies between the Physicians’ Desk Reference and the medical literature, and their possible role in the high incidence of dose-related adverse drug events. Arch Intern Med. 2001 Apr 9;161(7):957-64.
32. Cohen JS. Adverse drug effects, compliance, and the initial doses of antihypertensive drugs recommended by the Joint National Committee vs. the Physicians’ Desk Reference. Arch Intern Med. 2001 Mar 26;161(6):880-5.