Life Extension Magazine November 2005
The Perricone Weight Loss Program
By Nicholas V. Perricone, MD
SUPERSTAR SUPPLEMENT #12: DIMETHYLAMINOETHANOL (DMAE)
DMAE is a naturally occurring nutritional substance with powerful anti-inflammatory properties. It is found in fish, including wild Alaskan salmon, anchovies, and sardines. Back in the 1950s, DMAE was a prescription drug used as a treatment for central nervous system problems such as attention deficit disorder. Although it is no longer used for this purpose, it is being sold as a nutritional supplement for improving cognitive function, with additional benefits of improved memory and increased problem-solving ability. DMAE is important in the production of neurotransmitters, especially acetylcholine, which is essential in the communication from one nerve to another and between nerves and muscles. In order for your muscles to contract, the message must be sent from your nerves to your muscles via acetylcholine. DMAE also has membrane-stabilizing effects and can also help reduce body fat, most likely from its activity as a precursor to acetylcholine as well as its anti-inflammatory activity.
My recommended dose is 50 to 100 mg per day. For certain therapeutic uses, such as lowering cholesterol, larger doses may be recommended. As always, consult your physician.
The Perricone Weight-Loss Diet is not just about the foods we do or do not eat. It is also about understanding the actions we do in our daily lives that are pro-inflammatory, and learning how to change them. Many have a direct link to obesity and weight gain, as well as accelerated aging, wrinkles, the thinning of skin, the killing of brain cells and shrinking of the brain, and a weakened immune system.