Life Extension Magazine February 2007
As We See It
An Overlooked Strategy to Prevent Prostate Cancer
By William Faloon
If the prostate gland was not located in such a sensitive and difficult-to-reach area of the body, one could argue that most men should consider having it removed around the age of 50.
I made this seemingly bizarre statement 12 years ago, because the vast majority of aging men will contract benign or malignant prostate disease, either of which can lessen the quality and duration of life.1
While benign prostate disease is not usually thought of as life threatening, the sleep disturbance it causes due to nighttime urinary urgency could very well increase mortality. That is because people who do not get enough sleep overproduce inflammatory cytokines that inflict damage to arteries, joints, bones, and neurons.2-4 So while benign prostate enlargement itself seldom kills, the chronic sleep deprivation it induces may very well hasten death.
After the reproductive years, the prostate gland not only becomes a nuisance, but also hinders the ability of men to take advantage of validated anti-aging therapies. Elderly men frequently join Life Extension seeking a solution for the multiple degenerative diseases they have contracted. These ailing men are almost always severely deficient in testosterone and other critical hormones. Regrettably, many also have evidence of prostate cancer, which precludes them from gaining access to the benefits made possible by restoring all hormones to youthful levels.
Deficiencies of testosterone and DHEA are closely related to a host of common age-related diseases.5-31 In fact, low levels of these hormones can further spike dangerous inflammatory cytokine levels.32-37
The dilemma we face today is that certain age-related disorders can be partially reversed by restoring hormones to youthful ranges. For elderly men afflicted with prostate disease, this knowledge is of little practical value because they are unable to restore their full complement of hormones.
I cannot tell you how many cases I have encountered where elderly males suffer systemic disorders directly related to hormone imbalances. If it were not for their defective prostate glands, these men could enjoy the rejuvenating effects that have been shown when their hormones are returned to optimal ranges.
Take Control of the Statistics
More than 230,000 men are diagnosed each year with prostate cancer in the United States, and nearly 30,000 will die directly from it.38 Not counted in these epidemic statistics are the disabilities and deaths that occur in response to prostate cancer treatment.
Prostate cells are especially prone to mutation and malignant transformation.39-55 This process accelerates as men age past 50. Interestingly, cells of other tissues in the anatomical region of the prostate almost never become cancerous.
Are there ways to avoid becoming a victim of these grim statistics? We think so. First of all, the human body obviously has control mechanisms that keep isolated groups of malignant prostate cells in check. This is demonstrated by the high detection rate during autopsies of prostate cancer cells in males between the ages of 30 and 40.56 Men this young are almost never diagnosed with prostate cancer, but many have cancer cells lurking in their prostate glands. By harnessing the growth-control mechanisms of cancer cells, it would be possible to prevent (or delay) isolated cancer cells in the prostate gland from developing into full-blown disease.
Incidences of prostate cancer vary dramatically across the world. It is least common in South and East Asia, more common in Europe (especially northern Europe), and most common in the United States.57-61 Comparing prostate cancer rates in different regions of the world provides guidance as to what may be done to reduce risk. For instance, men in Sweden are eight times more likely to die of prostate cancer than men in Hong Kong.57,62
Scientists have identified a number of dietary factors that explain why certain population groups have such low prostate cancer rates.63-91 The encouraging news is that most Life Extension members are following at least some of the dietary and supplement guidelines that have been associated with reduced prostate cancer risks.
Are Men Doing Enough to Prevent Prostate Cancer?
A large percentage of men over the age of 70 already have cancer cells present in their prostate glands.59 The majority of these men, however, will never know they have prostate cancer. The reason is that most of them die of some other cause before prostate cancer manifests as clinical disease.
Life Extension members, on the other hand, are taking extraordinary steps to achieve a very long and healthy life. Instead of needlessly dying from a preventable disease, many male Life Extension members are likely to live long enough to encounter prostate problems.
So while health-conscious males take vitamin E,92-97 selenium,95,98-103 vitamin D,104-108 lycopene,109-115 gamma tocopherol,92,93,95 pomegranate,116-119 boron,120-123 fish oil,124-131 and other nutrients76,78,85,132-142 to prevent (or delay) prostate cancer, there is still a critical need to identify how relatively dormant cancer cells in the prostate gland eventually break through the body’s protective barrier to become clinically diagnosed prostate cancer.
Novel Mechanism to Impede Progression of Existing Prostate Cancer Cells
Since people are now living longer than ever, delaying the manifestation of prostate cancer is desirable, but may not result in the disease being altogether prevented. The lead article in this month’s issue of Life Extension magazine is titled “Eating Your Way to Prostate Cancer.” This article describes a little-known pathological mechanism that explains why ingesting the wrong foods increases prostate cancer risk.
Telling knowledgeable members about foods they know cause cancer does not do much good—unless a solution to impede the progression of existing prostate cancer growth is provided. The reason I state this is that many men reading this article have cells in their prostate glands that have mutated and/or have already become cancerous. While improving one’s diet at any age is of tremendous value, more has to be done to interfere with the progression of existing cancer cells that remain confined to the prostate gland.
In the breakthrough report you are about to read, we describe a patented plant extract that may provide aging men with additional protection against prostate cancer via a novel mechanism.
Members of the Life Extension Foundation do not have to concern themselves as to whether or not they need to include this patented plant extract in their daily program. It was added several months ago, at no additional cost, to the most popular prostate support formula Foundation members already use.
In the hormone-deficient aging male, the prostate gland too often becomes his Achilles heel. By taking aggressive steps to combat prostate disease, elderly men may enjoy their full complement of youth hormones . . . and still sleep through the night.
How Life Extension Protects Its Members’ Lives
Today’s apathetic physicians exhibit little in the way of curiosity when it comes to incorporating novel medical findings in their clinical practices. Life Extension researchers, on the other hand, are both personally motivated and have the dedicated time to meticulously review the scientific literature in order to identify novel strategies to prevent and treat age-related disorders.
If it were not for our fervent desire to eradicate needless suffering and death, these findings would remain buried in the thousands of pages of scientific text published every day.
In our daily battle against age-related disorders, Life Extension researchers uncover methods to enable elderly adults to achieve a more youthful biochemistry. Over the past two months, we have utilized these discoveries to upgrade virtually every popular supplement that members use every day.
Every time you purchase a product from us, you nourish your body with the world’s most advanced nutrients, and also directly contribute to aggressive life extension research that could save enormous numbers of human lives.
This time of year, members take advantage of the annual Super Sale to stock up on a large supply of avant-garde natural products at reduced prices. During this annual winter event, every Life Extension product is discounted to enable members to enjoy huge savings on our top-of-the-line supplements.
This year’s Super Sale ends on January 31, 2007. I encourage members to check their personal supplies and to stock up on the Life Extension products they need during this one-time-a-year price reduction.
For longer life,
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