Life Extension Magazine March 2007
Next-Generation Nutrients for Rapid Relief of Joint Pain
By Dale Kiefer
Hyaluronic Acid: Essential Lubrication to Cushion Joints
Comfortable joint movement depends on the presence of synovial fluid in the joint cavities. Hyaluronic acid is the primary natural polymer compound present in the synovial fluid of joints. Produced by specialized cells lining the fluid-filled sac surrounding joints, hyaluronic acid creates a viscous, cushioning environment for joint cartilage, preventing friction from damaging these hard-working tissues. In the presence of osteoarthritis, however, hyaluronic acid in the synovial fluid becomes less viscous and loses elasticity, while simultaneously decreasing in concentration. Ensuring optimal levels of hyaluronic acid is thus crucial to healthy joint function.
Recognizing the importance of hyaluronic acid in ensuring joint comfort, the American College of Rheumatology issued guidelines recommending the use of hyaluronic acid preparations for injection directly into the synovial spaces of joints affected by arthritis.20 While hyaluronic acid was once believed to offer only symptomatic relief from arthritis, in recent years physicians have noted that it may actually treat fundamental aspects of the disease. In addition to improving joint lubrication, supplemental hyaluronic acid appears to stimulate the body’s generation of new hyaluronic acid, while alleviating pain and inflammation.20-22
Recently published findings from a veterinary trial conducted in Lexington, Kentucky, show that orally administered hyaluronic acid improved the prognoses of yearling horses that underwent surgery on an equine joint that is roughly analogous to the human knee. The surgery’s purpose is to prevent degenerative joint disease and improve the performance of these equine athletes. In a blinded, placebo-controlled experiment involving 48 thoroughbreds, 30 days of post-operative use of oral hyaluronic acid significantly improved outcomes. According to the study investigators, “The oral hyaluronic acid showed benefit over the orally administered placebo for all lesions at all locations and of all sizes.” Noting that “anecdotal reports supporting the efficacy of these preparations already exist,” the researchers added that “the oral form is convenient and, therefore, may be preferable for routine use.”23,24
To see whether these encouraging results could be duplicated in humans, scientists performed a randomized, placebo-controlled, double-blind study of 20 patients with osteoarthritis of the knee. Each subject received 80 mg of a specially formulated, orally ingested hyaluronic acid supplement called Hyal-Joint™ or a placebo daily for two months. Although results are as yet unpublished, they indicate that the supplemented patients reported a statistically significant improvement in a standardized score of pain, as compared to those who received placebo. More specifically, patients who took the oral hyaluronic acid recorded a 33% improvement in their pain scores, compared to only a 6% improvement in the placebo group. Furthermore, this novel form of hyaluronic acid was found to be well tolerated and safe within the study parameters. Additional human trials using lower doses are reportedly under way. Research indicates that this unique form of hyaluronic acid is well absorbed from the small intestine. Importantly, Hyal-Joint™ (which is derived from natural tissues) demonstrates a superior ability to stimulate joint synovial fluid production, as compared to hyaluronic acid derived from bacterial synthesis.Scientists believe this hyaluronic acid formulation begins to increase the body’s natural production of hyaluronic acid within two to four weeks after beginning supplementation.25
Korean Angelica: A Fast-Acting Analgesic and Anti-Inflammmatory
As noted earlier, a major drawback of many traditional joint-health supplements is the absence of a compound that provides fast-acting pain relief. With this in mind, Korean researchers set out to develop a powerful natural pain reliever containing active ingredients derived from the herb known as Korean Angelica (Angelica gigas Nakai). Research has shown that this powerful analgesic and anti-inflammatory agent goes to work almost immediately in the body.
Unlike most prescription and over-the-counter pain relievers that inhibit the COX (cyclooxygenase) enzymes, this specialized form of Korean Angelica fights pain through its effects on the central nervous system. Studies suggest that this mechanism of action may involve the mediation of receptors for serotonin and noradrenaline, two nervous system messengers. Korean Angelica has demonstrated efficacy against numerous types of pain, especially inflammatory pain.26,27 Recently published findings indicate that one active ingredient derived from Korean Angelica inhibits activation of nuclear factor-kappa B (NF-kB), a DNA transcription factor that is activated in many inflammatory and disease states, including cancer.28
This ability to block NF-kB is highly significant, as evidenced by the fact that NF-kB and the signaling pathways that regulate its activity are under intensive study in the field of drug development. This is because NF-kB regulates the transcription of numerous genes, particularly those involved in immune and inflammatory responses, as well as those that confer resistance to programmed cell death.29
Like many of nature’s most potent medicinal herbs, Korean Angelica offers multiple potential benefits for human health. Cancer researchers are now focused on the potential ability of its active ingredients to prevent or treat prostate and other cancers.30-32 Furthermore, compounds extracted from Korean Angelica appear to protect the brain from a variety of insults, and may help mitigate susceptibility to Alzheimer’s disease.33,34 Thus, potent pain relief may be just one of many benefits offered by Korean Angelica. These benefits have been captured in a specialized extract of Korean Angelica called Decursinol-50 ™.
A multitude of studies support the value of glucosamine, MSM, and other slower-acting joint health compounds in promoting long-term improvement in and maintenance of joint function.
For those seeking faster relief from the pain and discomfort of arthritis and similar joint afflictions, newly developed compounds from keratin, hyaluronic acid, and Korean Angelica provide much-needed complementary support. When joint pain and stiffness make it difficult to wait for the healing to begin, these products have been shown to promote more rapid pain relief, improved joint lubrication, and quick healing and regeneration of joint tissue.
Because of the many distinct ways in which joints can degrade with aging, combining these next-generation nutrients with traditional joint-health supplements may provide the most comprehensive support for optimal joint structure and function.
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