Life Extension Magazine 2007
Enhanced Absorption Ubiquinol CoQ10
Findings just released at the 5th Annual International CoQ10 Symposium (November 9-12, 2007, in Kobe, Japan) show ubiquinol to be remarkably beneficial in those with advanced-stage cardiac disorders. Conventional CoQ10 (ubiquinone), on the other hand, was not adequately absorbed in these cardiac patients. According to the researchers, patients with severe heart failure have difficulty assimilating ubiquinone into their bloodstream, whereas ubiquinol readily absorbs and displays greater clinical benefit. (A full report on this landmark study will be described in the issue of Life Extension magazine that members will receive in January 2008.)
Not satisfied to produce the world’s best CoQ10 (ubiquinol), the largest Japanese maker of CoQ10 has just developed a patented method to enable even more ubiquinol to be absorbed than before.
This new enhanced-delivery ubiquinol formula is only available from the Life Extension Foundation Buyers Club. The incredible news is that this superior ubiquinol can provide more absorbed CoQ10 for less money than even the original ubiquinol.
More humans are supplementing with coenzyme Q10 than ever before. One reason is the increased awareness that the “statin” drugs used to lower LDL and cholesterol deplete the body of CoQ10.4-7
What most doctors don’t know, however, is that normal aging may result in a greater reduction in CoQ10 than is caused by taking statin drugs.8-10
For example, while statin drugs have been shown to reduce plasma CoQ10 by 40%, the aging process reduces CoQ10 levels in the heart muscle wall by 72%. The chart on this page reveals the CoQ10 deficiencies that occur in various tissues as humans age.11
What is particularly frightening is the thought of elderly people taking statin drugs who fail to supplement with CoQ10. The CoQ10 deficit caused by the dual effects of aging and statin drug use would result in severe depletion of cellular vitality.
CoQ10 and the aging mitochondria
About 95% of cellular energy is produced from structures in the cell called mitochondria. Coenzyme Q10 is incorporated into the mitochondria of our cells where it facilitates the transformation of fats and sugars into energy. A large body of scientific evidence shows that CoQ10’s ability to restore mitochondrial function has a profound effect on one’s overall health.12, 13
When CoQ10 levels diminish, the ability of cells to sustain even basic metabolic functions is impaired. This results in the development of multiple disorders characteristic of normal aging. Fortunately, coenzyme Q10 levels can be fully restored by taking the proper dose of supplemental CoQ10.
Heart cells have a high-energy demand, and many clinical studies have investigated the effect of CoQ10 on cardiac function. Efficacy has been shown in studies when CoQ10 was used for congestive heart failure, coronary artery occlusion, and valvular disorders.14,19 Scientists have also found that CoQ10 provides benefits to other organs whose cells require high-level energy metabolism such as the brain and kidneys.12, 20, 21
Why ubiquinol is superior to ubiquinone
Last year, Life Extension announced a technological breakthrough that enabled people to gain access to stabilized “ubiquinol” CoQ10 for the first time. Only modest doses of ubiquinol dramatically increased CoQ10 blood levels compared to conventional (ubiquinone) supplements.
In experimental studies, ubiquinol was shown to achieve 3.75 times higher plasma concentrations eight hours after dosing versus conventional CoQ10. Ubiquinol also reduced exercise-induced fatigue 90% better than conventional CoQ10.3
What most excited Life Extension researchers was a side-by-side comparison study that measured the rate of aging in mice given ubiquinol, ubiquinone, or placebo. As would be expected, both ubiquinone and ubiquinol slowed aging (by 45%) compared to placebo up to a certain point in the study. As the mice continued to age, however, the rate of aging in the ubiquinol group slowed until at one point in the study they were aging 40% less than the ubiquinone group and 51% less than the placebo group.3
Even more dramatic were photographs and video footage comparing the three different groups of mice. Twelve-month-old mice receiving no supplemental CoQ10 were essentially immobile and unresponsive, exhibiting lesions in and around the eye, with spinal and limb deformities as well as a patchy, discolored coat. Many of these pathological events seen in mice not supplemented with CoQ10 are classic signs of degenerative aging suffered by elderly humans. The ubiquinone group faired better, but visible signs of pathological aging were still clearly seen.3
On the other hand, the 12-month-old mice supplemented with ubiquinol, were shown to be alert, responsive, and energetic, with no physical lesions or deformities and a glossy coat resembling that of a young, healthy mouse. 3
A review of all the scientific findings clearly shows that ubiquinol is the preferred form of CoQ10 to ingest. As you will read next, Japanese researchers have discovered a delivery mechanism to provide even higher potencies of ubiquinol to the bloodstream.
Obtaining even higher blood levels of CoQ10
Over the past five years, scientists have discovered that higher doses of CoQ10 are needed to achieve optimal results. This originally caused a dilemma with consumers, as they were faced with having to swallow many expensive CoQ10 capsules to derive the desired benefits.
With the advent of stabilized ubiquinol, consumers could affordably achieve the high blood levels of CoQ10 that scientific studies showed provided optimal benefits.
Life Extension is pleased to announce the discovery of an enhanced ubiquinol delivery system that has been shown to double peak CoQ10 blood levels in mice compared to the original ubiquinol formula. Equally impressive is the ability of this enhanced ubiquinol formula to achieve 66% greater total amount of CoQ10 in blood over 24 hours than the original formula.
Human and animal research documents improved benefits when higher amounts of CoQ10 are delivered over a more sustained period of time. This new enhanced-absorbing ubiquinol may therefore provide greater biological effects than any previous CoQ10 supplement.
Exclusive absorption technology now available at lower prices
Life Extension has been issued an exclusive license to distribute this patented enhanced absorbing ubiquinol. Unlike greedy pharmaceutical companies that charge outlandish prices for trivial improvements to their drugs, the cost of this new enhanced delivery ubiquinol formula has not increased. It is in fact significantly lower priced than what the original ubiquinol capsules first sold for just one year ago!
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2. KANEKA CORP. Anti-fatigue effect in rats. Unpublished data, Kaneka Corp.
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