Life Extension Magazine March 2008
As We See It
Why a 100% Effective Diet Pill Would Lead to a Health Catastrophe
By William Faloon
By William Faloon
A local television personality I have known for years called to state he was finally ready to take every supplement I recommended. “Why the change?” I asked. It turned out that this television personality had developed full-blown type II diabetes.
My response was not what this shaken, newly diagnosed diabetic expected. I first related how I reduced my own calorie intake by mentally classifying most foods as “poisons.” Instead of viewing dangerous foods as treats, I instead visualize the damage inflicted on my DNA with each bite. Even when I succumb to culinary temptations, I now typically spit out the first bite and discard the dangerous food in the trash. Seeing garbage food in the trash (instead of feeling it in my bloated belly) conveys a sense of empowerment.
I told the TV personality: “You know what foods have made you diabetic. If you are unable to psychologically view these food groups as lethal toxins, there is little I can do to help you now.”
Just 45 days later, I received a pleasant call. My stark lecture about eating oneself to death had such a powerful impact that this TV personality changed his diet and lost 25 pounds. “Now,” I told him, “was the time to design a supplement program to improve insulin sensitivity and help protect against diabetic complications.”
Ignore Mass Media Advertising
People today are inundated with endless temptations to overeat unhealthy calories. A recent study at Cornell University documented something that most of us long ago came to realize. In a variety of settings, Cornell researchers showed that people are powerless to resist overeating if foods are visible and convenient. It turns out that hunger and good food are the last reasons why people overeat.1 Another recent study shows that specific changes happen in our brain when we are tempted with foods. These neurological alterations help explain the difficulties humans face when trying to follow a healthy diet.2
We now know that humans experience cravings for food, even when not hungry. Food industry promotion is thus analogous to how tobacco companies intentionally addicted customers during most of the previous century. For those who believe the government should protect consumers against dangerous industry practices, one could argue that a ban on unhealthy food advertising might save as many lives as today’s restrictions on cigarette advertising. Despite the well-known dangers of cigarette smoking, bad diets cause even greater numbers of cancers and other diseases.
My advice for Life Extension members is to regard most foods as poisons that will cause unimaginable suffering and premature death if not avoided. I realize how challenging food aversion can be when constantly being tempted throughout the day. The best advice I can give is to imagine how one’s life can come to a grinding halt once a serious disease such as cancer or stroke manifests. We know that eating sensibly reduces disease risk in people of all ages, so it is never too late to start healthy dietary practices.
Our Bloated Bloodstreams
Think for a moment how miserably uncomfortable your digestive tract is when you overeat. You may remember the old Alka-Seltzer® TV commercials that featured middle-aged people holding their stomachs saying, “I ate too much.”
The bloating effect that happens in our stomach and intestines in response to overeating also occurs in our bloodstream. When the blood is engorged with excess sugar and unhealthy fats, severe oxidative and inflammatory damage is inflicted to the inner arterial wall (the endothelium).3-7
Doctors have been slow to recognize the degradation in endothelial function that occurs every time we engage in gluttonous indulgence. Published studies have clearly documented the unfavorable arterial alterations that occur after eating just one high-calorie unhealthy meal.8-11 Now multiply that over a lifetime and it becomes apparent why so many humans succumb to vascular disease.
The injury imposed on the arterial wall after ingestion of unhealthy foods causes both acute and chronic pathologies. A man may be temporarily rendered impotent when his blood is bloated with saturated fats and sugars, while the long-term effect is systemic atherosclerosis.
So just imagine if the public had access to a pill that enabled them to eat all they wanted and never gain a pound. One lethal result would be skyrocketing cancer rates due to the DNA damage caused by both synthetic and natural mutagens that are ubiquitous in our food supply. The population would simultaneously suffer an even greater epidemic of endothelial dysfunction and arterial blockage caused by eating too much.
We are going to discuss an exciting new diet pill that has demonstrated better weight loss results than anything we found over the past 28 years. What we are not going to say, however, is that taking this pill will enable you to lose weight by following unhealthy dietary practices.
Restoring Youthful Calorie Fat Burning
For a variety of reasons, humans tend to accumulate excess fat as they enter middle age. One cause of age-associated weight gain is a slowdown in the rate at which our cellular mitochondria burn fats.
Reductions in mitochondrial fat-burning result in cell energy depletion that contributes to the fatigue and weight gain that aging humans encounter.
In the past, agents that have induced metabolic fat-burning have demonstrated mixed weight- loss results, with unpleasant reactions to their over-stimulatory effect being one reason why people could not ingest such supplements every day.
Life Extension was recently granted permission to briefly review confidential, top-line results of a clinical study pending peer-review publication in a leading scientific journal.
A novel plant extract called fucoxanthin was discovered by Japanese researchers and shown to induce between 10 and 12 pounds more weight loss compared with placebo over a 16-week period in women who consumed 1,800 calories per day. This study also showed beneficial changes in metabolic parameters including visceral body fat. Visceral body fat is a type of fat that surrounds the abdominal organs like the liver. Excess amounts of visceral body fat are linked to insulin resistance, type 2 diabetes, and cardiovascular disease. If the study was carried out for a longer period, the weight reductions would theoretically continue.24
The primary mechanism of fucoxanthin’s weight-loss action is accelerated fat-burning (thermogenesis) at the mitochondrial level.25,26 This plant extract was also shown to inhibit cells from storing more fat in culture studies, and particularly to reduce abdominal fat in other in vivo studies.26,27 In addition, it has been demonstrated that fucoxanthin markedly decreased blood glucose and plasma insulin concentrations.26,28
In another human trial, investigators were able to document significant increases in energy expenditure in response to ingestion of fuxoxanthin plus pomegranate seed oil after 16 weeks, compared with placebo.29 Unlike previous agents of this type, no central nervous system-stimulating effect occurs.
Reducing Blood Flow to Fat Cells
Aging is characterized by an increase in adipocytes (fat storage cells). Like benign tumors, adipocytes too often over-proliferate in maturing adults, contributing to the excess accumulation of body fat, particularly in the abdomen.
A special pomegranate seed oil has been shown to specifically interfere with the capillary network that feeds adipocytes. When administered to lab animals, pomegranate seed oil induced weight loss and fat reduction. The scientists who conducted this research concluded that this natural agent provided implications for the prevention of obesity.30,31
Don’t Let Diet Pills Shorten Your Life Span
We are excited about the prospects of these new plant extracts helping people to better manage their weight. We cannot lose focus, however, on the critical need for aging humans to eat a healthy calorie-controlled diet and stay physically active.
For many decades, unscrupulous companies promoted fat-loss products that claimed you could eat as much as you wanted and still lose weight. The reality is that most of these commercial formulations provided little in the way of meaningful fat loss.
A perfect biological diet pill would turn on genes at the cellular level to rid the body of excess fat cells and then help restore our youthful contour.
While the development of a truly effective fat-loss pill would result in a short-term reduction in obesity-related disease, the deadly effects of people chronically overeating (since they would not have to worry about weight gain) would cause a long-term health catastrophe greater than the epidemic of overweight and obesity does today.
The first article in this month’s issue discusses the science behind these two new plant extracts.
If you are overweight, and expect this pill to reduce body fat while you continue making poor dietary choices, then you have missed the entire point of this editorial. If, on the other hand, you want to increase your healthy life span by making the right food choices, then these plant extracts that safely increase mitochondrial fat-burning while reducing adipocytes, could significantly enhance the weight-loss effects of following a healthier lifestyle.
Real World Benefits
In my most recent conversation with the TV personality, he reports that he has been able to maintain his healthier weight by avoiding the “poisonous foods” I scared him away from.
The best news is that his doctor has proclaimed he is no longer a diabetic and that his blood pressure has been reduced without the need for prescription medications. He attributes the reversal of his diabetic condition to the dietary modifications I frightened him into making, the insulin-sensitivity restoring nutrients he began after losing the weight, and his modest increase in physical activity.
It is my hope that those suffering the ill effects of a poor diet will alter their perception and view unhealthy high-calorie foods as poisons that should be avoided. Those who choose to supplement with the new plant extract compound should enjoy additive fat-loss benefits.
For longer life,
1. Wansink B, Painter JE, Lee YK. The office candy dish: proximity’s influence on estimated and actual consumption. Int J Obes (Lond). 2006 May;30(5):871-5.
2. Rolls ET, McCabe C. Enhanced affective brain representations of chocolate in cravers vs. non-cravers. Eur J Neurosci. 2007 Aug;26(4):1067-76.
3. Shimabukuro M, Chinen I, Higa N, et al. Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study. Am J Clin Nutr. 2007 Oct;86(4):923-8.
4. Ceriello A. Impaired glucose tolerance and cardiovascular disease: the possible role of post-prandial hyperglycemia. Am Heart J. 2004 May;147(5):803-7.
5. Shankar SS, Mirzamohammadi B, Walsh JP, Steinberg HO. L-carnitine may attenuate free fatty acid-induced endothelial dysfunction. Ann NY Acad Sci. 2004 Nov;1033:189-97.
6. Gaenzer H, Sturm W, Neumayr G, et al. Pronounced postprandial lipemia impairs endothelium-dependent dilation of the brachial artery in men. Cardiovasc Res. 2001 Dec;52(3):509-16.
7. Holemans K, Gerber R, O’Brien-Coker I, et al. Raised saturated-fat intake worsens vascular function in virgin and pregnant offspring of streptozotocin-diabetic rats. Br J Nutr. 2000 Sep;84(3):285-96.
8. Plotnick GD, Corretti MC, Vogel RA, Hesslink R, Jr., Wise JA. Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal. J Am Coll Cardiol. 2003 May 21;41(10):1744-9.
9. Jakulj F, Zernicke K, Bacon SL, et al. A high-fat meal increases cardiovascular reactivity to psychological stress in healthy young adults. J Nutr. 2007 Apr;137(4):935-9.
10. Hennig B, Toborek M, McClain CJ. High-energy diets, fatty acids and endothelial cell function: implications for atherosclerosis. J Am Coll Nutr. 2001 Apr;20(2 Suppl):97-105.
11. Vogel RA, Corretti MC, Plotnick GD. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol. 1997 Feb 1;79(3):350-4.
12. Galili O, Versari D, Sattler KJ, et al. Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H904-11.
13. El Aoufi S, Gendre P, Sennoune SR, et al. A high calorie diet induces type 2 diabetes in the desert sand rat (Psammomys obesus). Cell Mol Biol (Noisy-le-grand). 2007;53 SupplOL943-53.
14. Zhao SP, Liu L, Gao M, et al. Impairment of endothelial function after a high-fat meal in patients with coronary artery disease. Coron Artery Dis. 2001 Nov;12(7):561-5.
15. Nappo F, Esposito K, Cioffi M, et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol. 2002 Apr 3;39(7):1145-50.
16. McLenachan JM, Williams JK, Fish RD, Ganz P, Selwyn AP. Loss of flow-mediated endothelium-dependent dilation occurs early in the development of atherosclerosis. Circulation. 1991 Sep;84(3):1273-8.
17. Huh KB, Lee HC, Cho SY, Lee JH, Song YD. The role of insulin resistance in Korean patients with coronary atherosclerosis. Diabetes. 1996 Jul;45 Suppl 3S59-S61.
18. Katakam PV, Ujhelyi MR, Hoenig ME, Miller AW. Endothelial dysfunction precedes hypertension in diet-induced insulin resistance. Am J Physiol. 1998 Sep;275(3 Pt 2):R788-92.
19. Jang Y, Kim OY, Ryu HJ, et al. Visceral fat accumulation determines postprandial lipemic response, lipid peroxidation, DNA damage, and endothelial dysfunction in non-obese Korean men. J Lipid Res. 2003 Dec;44(12):2356-64.
20. Raitakari M, Ilvonen T, Ahotupa M, et al. Weight reduction with very-low-caloric diet and endothelial function in overweight adults: role of plasma glucose. Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):124-8.
21. Nagamia S, Pandian A, Cheema F, et al. The role of quinapril in the presence of a weight loss regimen: endothelial function and markers of obesity in patients with the metabolic syndrome. Prev Cardiol. 2007;10(4):204-9.
22. Fontana L, Meyer TE, Klein S, Holloszy JO. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA. 2004 Apr 27;101(17):6659-63.
23. Sies H, Stahl W, Sevanian A. Nutritional, dietary and postprandial oxidative stress. J Nutr. 2005 May;135(5):969-72.
24. Ramazanov Z. The effect of Xanthigen™, a phytomedicine containing fucoxanthin and pomegranate seed oil, on body weight in obese non-diabetic female volunteers: a double-blind, randomized and placebo-controlled trial. Submitted for publication. 2008.
25. Argyropoulos G, Harper ME. Uncoupling proteins and thermoregulation. J Appl Physiol. 2002 May;92(5):2187-98.
26. Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin. J Oleo Sci. 2007;56(12):615-21.
27. Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun. 2005 Jul 1;332(2):392-7.
28. Maeda H, Hosokawa M, Sashima T, Miyashita K. Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice. J Agric Food Chem. 2007 Sep 19;55(19):7701-6.
29. Ramazanov Z. Effect of Fucoxanthin and Xanthigen™, a phytomedicine containing fucoxanthin and pomegranate seed oil, on energy expenditure rate in obese non-diabetic female volunteers: a double-blind, randomized and placebo-controlled trial. Submitted for publication. 2008.
30. Lei F, Zhang XN, Wang W, et al. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes (Lond). 2007 Jun;31(6):1023-9.
31. Toi M, Bando H, Ramachandran C, et al. Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo. Angiogenesis. 2003;6(2):121-8.