Life Extension Magazine

Life Extension Magazine June 2009

As We See It

Why Aging People Fail to Lose Weight

By William Faloon

William Faloon Picture taken February 2009 Age 54 (About 20 pounds lighter in response to Irvingia) 
William Faloon Picture taken February 2009 Age 54 (About 20 pounds lighter in response to Irvingia)
William Faloon Picture taken December 2007 
William Faloon Picture taken December 2007

My photo is updated every few years so that members can see that I too am aging. Beginning in July 2008, however, a pleasant personal ambiance set in as my appetite diminished in response to taking two Irvingia capsules each day.

When reviewing scientific studies, I consistently observe that the incidence of most diseases directly correlates with how many calories one consumes. If we eat less, our risk of contracting age-related disease is considerably reduced. I analogize excess calorie intake to cigarette smoking: just as every inhaled cigarette reduces life span, so may every excess calorie bring us closer to personal extinction.

So you can imagine how enthusiastic I was when Irvingia enabled satiety to occur in me after eating relatively few calories. I lost four inches off my waistline and about 20 pounds of total weight—and have kept it off!

Not everyone has obtained the same benefits from Irvingia as I have. In this issue of Life Extension® magazine, we uncover why some aging people find it so difficult to shed fat pounds. We then reveal real-world strategies that are proven to work (some even FDA-approved), but have been overlooked by both conventional and complementary medical doctors.

Customer Responses to Irvingia

In November 2008, Life Extension® introduced a product called Irvingia gabonensis that had demonstrated dramatic results in human clinical studies.

Since its launch six months ago, Irvingia has become the most popular supplement that Life Extension has ever offered. The weight-loss study we reported on last November is now formally published in a peer-reviewed scientific journal.1 Publication provides Irvingia with important standing in the medical community, as doctors expect studies they rely on to undergo rigorous review by outside experts.

Customer Responses to Irvingia

We have received an unusual number of positive responses from Irvingia users describing weight loss, along with consistent reports of a reduction in appetite without stimulating effects. Most of our members want to eat less without feeling hungry.

The re-order rate on Irvingia is almost double that of any other product, which reflects a high level of customer satisfaction. Scientific studies continue to validate the novel mechanisms by which Irvingia has been described to induce body fat loss.2-4

Why We Are Not Satisfied With Irvingia

Despite the impressive clinical data and fat-loss results we are seeing, too many members state that they are not achieving the expected benefits in response to Irvingia. Here is a brief summary of the issues we have with Irvingia:

  1. The reductions in cardiac risk markers that occurred in two human clinical studies (LDL, total cholesterol, glucose, etc.) probably happened in direct response to body fat loss. In other words, Irvingia itself may not have been responsible for these extremely favorable changes in cardiovascular risk profiles.1,5
  2. Too many members report that they are not losing weight, or not losing the desired amount of weight in response to Irvingia.
  3. Obesity-inducing factors prevalent in the Western diet have been identified that require more than Irvingia alone to circumvent.

Missing Links That Preclude Weight Loss

Life Extension’s research staff conducted an exhaustive search of the published scientific literature to uncover why so many overweight Americans cannot shed significant fat pounds.

Why We Are Not Satisfied With Irvingia

As you will read in the three articles in this month’s issue, most of us have become addicted to a lifestyle that virtually guarantees chronic age-associated weight gain, especially in the abdominal region.

The good news is that when properly taken, currently available nutrients, drugs, and hormones can thwart these insidious obesity-inducers. In fact, the underlying scientific data supporting these approaches are quite impressive. Lacking up until now, however, is a cohesive approach that incorporates all of these discoveries into a comprehensive weight-loss program.

For example, drugs that block dietary fat absorption into the bloodstream have proven efficacy.6-9 Using this fat-blocking method alone, however, fails to meet the expectations of most overweight individuals. One reason is that excess carbohydrate absorption will cause the same disruption of metabolic processes as does overconsumption of dietary fats.

On the flip side, drugs or nutrients that block the rate of carbohydrate absorption may not induce profound weight loss if too many dietary fats wind up in the bloodstream.

Missing Links That Preclude Weight Loss

What people fail to accept is that as they grow older, they lack the metabolic capacity to efficiently convert ingested calories into energy. These metabolic deficits are increasingly being referred to as “postprandial disorders.” The term postprandial means after-meal and the disorders they refer to are too many fats and sugars remaining in the bloodstream long after meals are eaten.

Overweight individuals today suffer chronically high blood levels of fat remnants and glucose that may frustrate the best laid-out weight-loss program.8,10

One might think that by merely eating less, blood fat (triglycerides) and sugar (glucose) levels will drop low enough to prompt weight reduction. The harsh reality is that many overweight individuals are so severely compromised on a metabolic and hormonal basis that sustained fat loss cannot be achieved unless corrective actions are first taken. An imbalance of insulin, thyroid, and/or sex steroid hormones, for example, may prevent the desired release of stored body fat, even in response to calorie restriction.

As humans age, there is a progressive and extensive decline in resting cellular energy expenditure. This reduction in metabolic rate is another reason that people accumulate more body fat, even though they may be eating less than they used to.