Life Extension Magazine February 2010
As We See It
Reap Benefits of Calorie Restriction without Chronic Hunger
By William Faloon
Practical Options to Emulate Calorie Restriction
The scientific data solidly document that surplus calorie intake shortens your life span.87,88 Everyone responds differently when reducing food intake, but most people can at least modestly decrease the number of calories they consume each day.
Most individuals, however, will still eat more than they should. Fortunately, there are multiple ways to inhibit the activity of digestive enzymes, and thus spare most of the body from the lethal effects of excess calorie absorption. An aggressive three-month plan to reduce the number of absorbed calories involves taking the following nutrients and drugs before most meals:
For some individuals, drugs like orlistat that inhibit lipase will cause gastrointestinal discomfort after eating too much. One objective of suggesting a 90-day trial using this drug is to forcibly educate you about healthier lifelong dietary patterns. For example, if you continue to consume excess fat calories and take orlistat, the result will be lots of lipid-laden feces in the toilet after a bowel movement. Understanding that this fat appearing in your toilet was destined to be absorbed into your bloodstream (which could shorten your life span) may motivate you to eat less. Likewise, digestive discomfort associated with excess carbohydrate intake in the presence of alpha-glucosidase, amylase, and sucrase inhibitors may entice you to reduce intake of dangerous simple carbohydrates. In case you have not figured this out yet, a side benefit to doing all this is a loss of surplus body fat.
To mimic some of the favorable gene expression changes that occur in response to calorie restriction, a new nutrient formula called Calorie Restriction Mimetic Formula has been developed that consists of the following nutrients in the daily dose:
These and a number of other nutrients that health-conscious people already take, such as high dose vitamin D3 and fish oil, have been shown to favorably alter gene expression.89-101
We Live in an Exciting Era!
Scientists continue to validate the health benefits of nutrients that Life Extension members supplement with every day. Only recently, however, have these favorable effects been linked to the ability of these nutrients to mimic gene expression changes that occur in response to calorie restriction.72, 101-105
An explosive volume of newly published research indicates that aging humans can exert tremendous degrees of control as to whether they maintain youthful or senescent gene expression patterns in their cellular DNA.106-108
Some youthful gene expression can be maintained by reducing intake of calories to a level 20-40% lower than is typical, while still obtaining all the necessary nutrients and vitamins.13,109-113 The most recent study indicates even a modest calorie restricted diet produces huge reductions in degenerative disease in monkeys.13
Those who are unable to sufficiently cut their food intake can still inhibit the absorption of ingested calories by taking compounds (such as orlistat, acarbose, and/or the new Optimized Irvingia formula) that block digestive enzyme activity.
Finally, and most exciting of all, there are nutrients (such as pterostilbene and resveratrol) that have been shown to mimic many of the favorable effects induced by calorie restriction.102-104,114-116 These low-cost nutrients provide humans with an unprecedented power to determine whether their cellular DNA expresses youth-promoting or senescent-inducing genes. Humans have never enjoyed so much control over the rate that they age!
Advanced NutritionalFormulas at the Year’s Lowest Prices
For more than two decades, Life Extension members have taken advantage of the annual Super Sale to acquire their favorite nutrient formulations.
Life Extension upgrades its formulas almost every year to provide more effective health-sustaining nutrients. In the last few months, we introduced a new form of ubiquinol CoQ10 that is significantly better absorbed into the cell’s mitochondria, standardized apigenin to maintain healthy cell division, and a novel plant compound that protects against persistent inflammatory joint conditions.
In this month’s issue, you’ll learn about nutrients that help arouse youthful gene expression changes, along with a new carbohydrate blocker (sucrase) that diminishes the amount of unwanted glucose absorbed into your bloodstream.
Every time you purchase a Life Extension® product, you contribute to research aimed at radically extending the healthy human lifespan. Last year, the Life Extension Foundation funded a record number of scientific projects.
During the traditional winter Super Sale, all Life Extension formulas are discounted so that members can obtain up-to-date versions at the lowest prices of the year.
Until February 1, 2010, members take advantage of Super Sale discounts to stock up on the world’s most avant-garde life-extending formulations.
For longer life,
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