Life Extension Magazine May 2010
Is Conventional Pomegranate Extract Enough?
By Julius Goepp, MD
By Julius Goepp, MD
Pomegranate Seed Oil: A Potent Cancer Fighter
Cutting-edge research has uncovered numerous life-saving modes of action for pomegranate seed oil, most notably in the area of chemoprevention.2 Other roles for pomegranate seed oil include facilitating repair of aging skin, immune function modulation, and inflammation reduction.2,31-33
The data on pomegranate seed oil’s cancer fighting potential is most compelling in tissues of the male and female reproductive systems. Pomegranate seed oil is a potent inhibitor of aromatase, the enzyme that produces estrogen from testosterone, and 17-beta-hydroxysteroid dehydrogenase type 1, which is responsible for the conversion of estrone to potent estradiol. This enzymatic blockade contributes to pomegranate seed oil’s ability to inhibit growth of estrogen-dependent breast cancer cells in culture. It also reduces the cancer cells’ invasiveness (ability to cross barriers). A separate mechanism is also clearly at work here, because the oil also increases cellular suicide (apoptosis) even in cancer cells that lack estrogen receptors.34
Cancer cells need to grow new blood vessels to support their rapid growth and tissue invasion (angiogenesis). They typically do this by ramping up production of a variety of growth factors, including vascular endothelial growth factor (VEGF) and inflammatory interleukins.
Pomegranate seed oil powerfully inhibits production of VEGF while upregulating production of migratory inhibitory factor (MIF) in breast cancer cells. In a laboratory model of vessel growth, these modulations translated into a significant decrease in new blood vessel formation.35 Pomegranate seed oil’s capacity to block breast cancer development was also demonstrated in an organ culture model of mouse breast cancer.36 Treating the glands with the oil prior to exposure to a powerful carcinogen resulted in an astonishing 87% reduction in the number of cancerous lesions compared with controls—substantially greater protection than has been previously reported for derivatives of pomegranate juice.
As with flower extracts, pomegranate seed oil contains a number of unique chemical constituents with potent biological effects. Punicic acid is an omega-5 polyunsaturated fatty acid that inhibits both estrogen-dependent and estrogen-independent breast cancer cell proliferation in lab cultures.37 Punicic acid also induced apoptosis at rates up to 91% higher than those in untreated cell cultures—effects which appear to be related to fundamental regulation of cancer cell signaling pathways.37
Another common malignancy that often depends on sex hormones for its growth is prostate cancer, a leading cause of cancer-related mortality in American men, accounting for more than 29,000 deaths each year.38 Because of its slow rate of growth and appearance later in life, prostate cancer has been identified as an ideal target for nutritional chemoprevention.10
Pomegranate seed oil sharply inhibits proliferation of a number of human prostate cancer lines through changes in the cell growth cycle and also by inducing apoptosis (cell death). At the same time, it has been shown to powerfully suppress cancer cell invasion.39 Pomegranate oil also acts in synergy with other pomegranate components, suppressing prostate cancer proliferation and metastatic potential more effectively than each component individually.40
An abundance of data supports the power of pomegranate extract as a broad-spectrum, multi-modal defense against multiple diseases of aging. It has been shown to inhibit pro-inflammatory nuclear factor-kappaB (NF-kB), downregulate production of certain cancer-stimulating androgens, and upregulate expression for the paraoxonase molecular complex associated with artery-cleansing HDL.
The most recent research suggests that the various botanical components of the fruit tree may be required to obtain pomegranate’s full protective benefit, in particular its flowers and seeds.
Extracts from pomegranate flower have been shown to suppress signaling of endothelin-1, a blood vessel-narrowing peptide implicated in cardiac fibrosis (abnormal thickening of the heart valves) and to help arrest the onset of metabolic syndrome as well as its associated pathologies of obesity, type 2 diabetes, and heart disease.
Pomegranate seed oil offers further promise as a powerful anti-cancer agent, with particular potential in combating breast and prostate cancers.
There is now solid published data to support the value of supplementing with pomegranate fruit extract, along with pomegranate flower and seed oil extracts.
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