Life Extension Magazine February 2011
Generate Fresh Mitochondria with PQQ
By Perry Marcone
As with stroke, damage in heart attack is inflicted via ischemia-reperfusion injury. Supplementation with PQQ reduces the size of damaged areas in animal models of acute heart attack (myocardial infarction).52 This occurs whether the supplement is given before or after the ischemic event itself.
To further investigate this potential, researchers at the VA Medical Center at UC-San Francisco compared PQQ with metoprolol, a beta blocker that is standard post-MI clinical treatment. Given alone, both treatments reduced the damaged areas’ size and protected against heart muscle dysfunction. When they were given together, the left ventricle’s pumping pressure was enhanced. The combination also increased mitochondrial energy-producing functions—but the effect was small compared with PQQ alone! And only PQQ favorably reduced lipid peroxidation. The remarkable conclusion: “PQQ is superior to metoprolol in protecting mitochondria from ischemia/reperfusion oxidative damage.”53
Subsequent research from the same team has demonstrated that PQQ helps heart muscle cells resist acute oxidative stress.54 The mechanism? Preserving and enhancing mitochondrial function.
Mitochondrial dysfunction has been definitively linked to virtually all killer diseases of aging, from Alzheimer’s disease and type 2 diabetes to heart failure.
Researchers have recorded evidence of greater mitochondrial damage in the brain cells of humans over 70 compared to those in their early 40s. The health and function of these cellular energy generators is now considered so vital that many scientists believe mitochondrial longevity determines overall longevity in aging humans.
In a revolutionary advance, an essential coenzyme called pyrroloquinoline quinone or PQQ has been shown to induce mitochondrial biogenesis—the growth of new mitochondria in aging cells!
While CoQ10 optimizes mitochondrial function, PQQ activates genes that govern mitochondrial reproduction, protection, and repair. PQQ also affords potent cardioprotection and optimal defense against neuronal degeneration. Published studies show that 20 mg of PQQ plus 300 mg of CoQ10 may reverse age-related cognitive decline in aging humans.
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