Life Extension Magazine August 2011
By Lara Pizzorno, MA, LMT, and Jonathan V. Wright, MD
What’s Hyperparathyroidism and Why Should My Bones Care?
Hyperparathyroidism is overactivity of the parathyroid glands (hyper = excessive, above normal), resulting in excessive production of parathyroid hormone. Hyperparathyroidism is divided into “primary” and “secondary” types.
“Primary” hyperparathyroidism is relatively rare. It’s a disease of the parathyroid glands themselves, usually of unknown origin, and is almost always the more severe form. Sometimes surgery is required as part of treatment.
“Secondary” hyperparathyroidism is almost always milder, and not always diagnosed as such. Secondary hyperparathyroidism is not a disease (as the primary form is) but a protective response by the body to increase blood levels of calcium from unhealthy low levels caused by inadequate calcium intake or the many other causes listed below.
But although parathyroid hormone causes an increase in the body’s production of the most active form of vitamin D (1,25-dihydroxyvitamin D), which helps us absorb more calcium from our intestines, parathyroid hormone also causes increased osteoclast activity and bone resorption (bone breakdown) in order to liberate calcium from bone for calcium’s many other immediate uses in the body.
Blood levels of calcium low enough to cause secondary hyperparathyroidism are typically due to not getting enough daily calcium, vitamin D deficiency, chronic kidney disease, chronic liver disease, low levels of stomach acid (hypochlorhydria, relatively common after age 50), malabsorption of calcium (and other minerals, most often caused by “hidden” gluten sensitivity), or gastric bypass surgery. Obesity has also been shown to increase parathyroid hormone levels, which, in addition, tend to increase with age in both men and women.
Above normal levels of parathyroid hormone have recently been associated not only with oste oporosis, but also with cognitive decline and senile dementia (Alzheimer’s disease). The connection is most likely explained by the fact that sustained high levels of parathyroid hormone in the brain increase risk of calcium overloading, which leads to impaired blood flow and brain degeneration.17
Fortunately, a recent study involving 37 institutionalized women, ranging in age from their late 70s to late 80s, has shown that consumption of a fortified dairy product, containing only about 17–25% of the recommended daily intakes for calcium and vitamin D, lowered levels of parathyroid hormone and increased levels of both vitamin D and markers of bone formation in just one month.18
What Does This Mean for YOU?
The lab tests ordered at your annual physical should include blood levels of parathyroid hormone. Normal values range from 10–55 picograms per milliliter (pg/mL); however, recent research suggests values higher than 30 may indicate suboptimal intake of calcium and vitamin D.19
Higher than normal levels of parathyroid hormone indicate that you are not meeting your body’s needs for calcium and vitamin D, and that you are at increased risk not only for osteoporosis but cognitive decline and Alzheimer’s disease. Work with your doctor to increase your consumption of calcium and vitamin D, and recheck your levels of parathyroid hormone after a month to two months on your new and improved bone health promotion program.
Is Your Thyroid on Overdrive?
Hyperthyroidism (a “hyperactive” thyroid) is a well-known risk factor for osteoporosis, regardless of sex or age. The hormones produced and secreted by the thyroid gland regulate the body’s metabolic rate. When thyroid hormone levels are too high, regardless of whether we are pre- or post-menopausal, female or male, it’s like putting the body into overdrive, accelerating all its metabolic activities, including the rate at which bones are remodeled, all the time.
Each bone remodeling cycle involves 3-5 weeks of bone breakdown by osteoclasts followed by about 3 months during which osteoblasts lay down new bone to replace the bone that was removed. The result of the fast-forward bone metabolism seen in hyperthyroidism is increased bone resorption that leads to a loss of approximately 10% of bone mass per remodeling cycle. Not surprisingly, this can quickly result in lowered bone mineral density and increased risk of fracture.20,21 Fortunately, hyperthyroidism is relatively uncommon.
Gloria Vanderbilt Once Said, “A Woman Can’t Be Too Rich or Too Thin.” She Was Half-Wrong.
Anorexia nervosa, an eating disorder characterized by intense fear of gaining weight and becoming fat, despite being underweight (weighing less than 85% of the weight considered normal or healthy for one’s height and build), causes bone loss, particularly in the spine and hip.22,23 This is not surprising since bones cannot be built without a whole team of nutrients and also respond by strengthening when stressed by weight—which is why resistance exercises help build bone.
Avoiding food, self-induced vomiting, and use of laxatives, diuretics, and/or appetite suppressants is a sure-fire recipe for bone starvation. Lack of sufficient nourishment not only causes a premenopausal woman to stop menstruating and lose bone, but also causes her to lose muscle and turn into a Skeletor cartoon character look-alike.
The stress that muscles put on bone when they contract is a key “time to build more bone” signal. Women are already at a bone-building disadvantage compared to men because our muscles are smaller. Cannibalize your muscles, and you thin your bones. The complete loss of menstrual periods, amenorrhea, occurs largely because the body is no longer willing to use the energy needed to produce estrogen, which regulates osteoclasts, preventing them from removing too much bone.
Bone-Busting Patent Medicines
If you are taking any of the following patent medicines, work with your physician to help compensate for their bone-destroying effects or, if possible, to find an alternative less harmful to your bones.
Avandia® (rosiglitazone) and Actos® (pioglitazone): Use of the diabetes patent medicines Avandia® or Actos® for more than a year doubles to triples risk of hip fractures.24-27
These patent medicines, members of a class of patent medicines called thiazolidinediones (also known as glitazones), are insulin-sensitizing medications that account for approximately 21% of the oral blood sugar-lowering patent medicines used in the US. Although their main therapeutic effects occur in fat tissue, muscles, and the liver, studies show they affect bone as well. They do so by triggering mesenchymal stem cells, which can become any one of several different types of cells, including osteoblasts, chondrocytes (cells that produce cartilage), or adipocytes (fat cells), into choosing to become adipocytes. When you take these patent medicines, your body makes more fat and less bone.
Because studies have demonstrated accelerated bone loss, impaired bone mineral density, and increased fracture risk for thiazolidinedione users, clinicians have been told to carefully assess the fracture risk in their patients with type 2 diabetes before starting them on thiazolidinediones.28
Anticonvulsants: Barbituates such as phenobarbital or Mysoline® (primidone) alter the metabolism of vitamin D. Dilantin® (phenytoin) interferes with vitamin D and may also cause a deficiency of folate or B6, or a reduction in blood levels of vitamin K, all of which are essential for building and maintaining bone.
Chronic Opioid Therapy: Used in the management of chronic pain, opioid patent medicines (e.g., morphine, codeine, hydrocodone, oxycodone, methadone, tramadol) greatly impact the production of a number of hormones, including two with significant effects on bone: estrogen and thyroid-stimulating hormone (TSH). A study of 47 women, aged 30 to 75, who were using oral or transdermal opioids for control of nonmalignant pain found estradiol levels were 57% lower than in control subjects! These patent medicines inhibit estrogen production so effectively that among premenopausal women, menstruation typically ceases soon after initiating opioid therapy. In contrast, opioid patent medicines increase the production of TSH, which directly suppresses bone remodeling. The combined effect of suppressing estrogen production and increasing that of TSH is greatly increased risk of osteoporosis. Women needing opioids for relief of chronic pain should discuss bioidentical hormone replacement with their physicians.29-33
Glucocorticoid patent medicines: Often mistakenly termed “cortisone,” these patent medicines include prednisone, prednisolone, Kenalog®, dexamethasone, and nearly anything else ending in “-one,” along with the nonpatentable Cortef®, which is bioidentical cortisol, but as a prescription often used in excess of normal body levels. These patent medicines kill osteocytes (which is what osteoblasts turn into after they begin secreting the bone matrix). Thus, these patent medicines cause a rapid weakening of bone architecture (within 6 months of initiating treatment) even at very low doses. In addition, the glucocorticoid patent medicines deplete the body of vitamin D3, interfering with normal calcium metabolism and absorption. One reason smoking is so harmful to bone is that nicotine causes the body to produce excess cortisol.34-36
Antacids/Proton-pump inhibitors: For calcium to be absorbed, it must first be made soluble and ionized by stomach acid. These patent medicines inhibit or even totally prevent your body’s ability to produce stomach acid.
Are Your Bones Going Up in Smoke?
Smokers lose bone more rapidly, have lower bone mass (a full one-third of a standard deviation less at the hip and a one-tenth standard deviation less for all sites combined), and a higher fracture rate. In addition, women who smoke reach menopause, when estrogen levels plummet causing bone loss, up to two years earlier than their nonsmoking peers.37-40
Approximately 19% of the hip fractures occurring in a study that pooled data from three population studies involving a total of 13,393 women and 17,379 men were attributable to smoking.41 In other research, smoking increased risk of spinal osteoporosis in men by 230%!42
More than Two Drinks of Liquor Makes Bone Loss Much Quicker
Alcohol has a dose-dependent toxic effect on osteoblast activity. One to two drinks a day appears to be beneficial. More than two drinks a day prevents bone repair and renewal and significantly increases fracture risk.43,44
Using data from the Third National Health and Nutrition Examination Survey, researchers found that moderate drinkers (less than 29 drinks per month) actually had higher BMD than abstainers. Moderate consumption of alcohol translated to 2.1% higher BMD in men and 3.8% higher BMD in postmenopausal women.45 Another large study, this one involving 11,032 women and 5,939 men, found no increase in fracture risk when two ounces or less of alcohol was consumed daily, but drinking more than this increased risk of any osteoporotic fracture by 38% and hip fracture by 68%.46
Your choice of which alcoholic beverage to consume can also affect the health of your bones. Several recent studies suggest moderate intake (no more than two servings a day) of beer and/or wine may have beneficial effects on bone. (One serving of beer = 8 ounces; one serving of wine = 4 ounces.) A study of 1,697 healthy women, of whom 710 were premenopausal, 176 were perimenopausal, and 811 were postmenopausal, found that beer drinkers had slightly higher bone mass.47
A second large study involving 1,182 men, 1,289 postmenopausal woman, and 248 premenopausal women found bone mineral density was 3.0–4.5% greater in men consuming 2 daily drinks of alcohol or beer, and 5.0–8.3 greater in postmenopausal women consuming 1–2 drinks of alcohol or wine daily. More than 2 drinks a day, however, was associated with significantly lower (3.0–5.2% lower) bone mineral density in the hip and spine in men.
Beer’s beneficial effects on bone are thought to be due to its silicon content. One can of beer contains around 7 milligrams of silicon; a 4-ounce glass of wine provides around 1 milligram of silicon. (For comparison, a half cup of cooked spinach contains around 5 milligrams of silicon.)
Wine’s bone benefits may be linked to its content of phytochemicals, especially the resveratrol present in red wine, which has been shown to have estrogenic effects and might therefore help protect against bone loss in postmenopausal women in whom estrogen levels are low. In rat studies, resveratrol has been shown to have an estrogenic effect and to promote increased BMD in ovariectomized rats (rats whose ovaries have been removed to simulate menopause).48-50
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Excerpted from Your Bones, How You Can Prevent Osteoporosis & Have Strong Bones for Life – Naturally by Lara Pizzorno, MA, LMT with Jonathan V. Wright, MD. Reprinted with permission from Praktikos Books.