Life Extension Magazine

Life Extension Magazine October 2012

Report

Powerful Protection Against Cellular Aging

By Michael Downey

Powerful Protection Against Cellular Aging

Conclusive evidence now indicates that PQQ (pyrroloquinoline quinone) activates cell signaling pathways that have the potential to reverse cellular aging!1

PQQ has previously been shown to promote growth of new mitochondria within aging cells,1-3 up-regulate cellular metabolism,1,2 protect neurons,4-7 and repair DNA!1,8

These and other synergistic signaling effects have the combined ability to promote longevity at the critical subcellular level.

PQQ has been found in all plant species ever tested. Scientists have gone so far as to state that PQQ may be "vital to life."3

An Essential Anti-Aging Nutrient

Scientists have found that PQQ, a critical coenzyme, plays a leading role in boosting critical cell signaling mechanisms.3

These signaling pathways regulate a variety of physiological and molecular processes throughout the body10—processes that have an impact on key biomarkers of aging, such as mitochondrial function11-16 and cellular defense against oxidative stress.10

An Essential Anti-Aging Nutrient

Through these effects, the cell signaling power of PQQ targets aging at both the cellular and subcellular levels.

New research confirm that humans can obtain these multiple benefits after even just short-term supplementation.17

A wealth of studies now confirm that PQQ's cell-signaling activity translates into substantial protection against degenerative and age-related conditions, such as mitochondrial dysfunction,1 heart degeneration,18-20 brain injury, and cognitive decline.21-40 As one example, research shows that 20 mg of PQQ daily may reverse age-related cognitive decline in aging humans!

Since PQQ cannot be synthesized by your body it is necessary to obtain PQQ from outside sources.24,41-43 Fortunately, compared to other plant compounds, PQQ has greater solubility and bioavailability. PQQ is water-soluble and therefore, more easily absorbed at low supplemental intakes.1,44,45

Let's take a look at the modes of action behind PQQ's multiple effects.

PQQ and Cell Signaling

How can PQQ target multiple aging factors?

The answer lies in the potent and unique capacity of PQQ to activate cell signaling pathways, especially those directly involved in cellular energy metabolism.

Also, similar to the action of CoQ10, PQQ actively participates in the energy transfer within the mitochondria that supplies the body with most of its bioenergy.

PQQ can even trigger spontaneous mitochondrial biogenesis—the creation of fresh, new mitochondria!

Specific cell signaling molecules have been found to be directly activated by PQQ.

Cell Signaling Pathways

Early studies revealed that animals deprived of PQQ exhibit signs of accelerated aging in the form of elevated plasma glucose concentrations, impaired oxygen metabolism, stunted growth, compromised immunity, impaired reproductive capability, reduced numbers and survival rate of offspring, and a decrease in energy-producing mitochondria in their tissue. Reintroducing PQQ to their diet reversed these effects, increasing mitochondrial numbers and restoring systemic function.46-48

PQQ is now linked to favorable effects on cell development, metabolism, and mitochondrial biogenesis. It provides the potential to reverse cellular aging and age-related disease by:

  • Stimulating spontaneous growth of new mitochondria within aging cells.1
  • Regulating gene expression.3
  • Promoting tumor cell death from apoptosis.49
  • Supporting mitochondrial protection and repair.1
  • Providing powerful antioxidant support to mitochondria and other body molecules—with up to 5,000 times the effect of other antioxidants,4 and protecting the brain's cells and neurotransmitter systems against neurotoxicity5,39,50 and amyloid-beta protein.36

The end result of PQQ's activity is subcellular anti-aging and enhanced longevity.

(For more on these beneficial pathways, see previous box titled, 'PQQ and Cell Signaling.')

Heart Benefits

PQQ's cell signaling activities produce measurable health improvements, especially cardio-protective and neuro-protective benefits.

For example, research with animals found that supplementation with PQQ decreased the size of the area of the heart injured by acute coronary artery blockage. This protective effect was found whether PQQ was given before or after the event—suggesting taking PQQ within the first hours following a cardiac event could deliver invaluable benefit to patients.18

Following up on this research, scientists then tested both PQQ and the common post-heart-attack treatment metoprolol (Lopressor®). They found that, while both reduced the size of the damaged area, there was a greater increase in mitochondrial energy-producing functions with PQQ.

And only PQQ lowered lipid peroxidation!

The study team concluded that "PQQ is superior to metoprolol in protecting mitochondria from ischemia/reperfusion oxidative damage."19

These same scientists found in later animal research, that "PQQ reduces oxidative stress, mitochondrial dysfunction, and cell death" in cardiac muscle cells.20

What You Need to Know

PQQ: Powerful Protection Against Cellular Aging
PQQ: Powerful Protection Against Cellular Aging
  • Pyrroloquinoline quinone (PQQ) activates a number of vital, cell signaling pathways involved in protecting against cellular aging!
  • PQQ-powered signaling mechanisms create fresh mitochondria,1-3 upregulate cellular metabolism,1,2 improve cognitive performance and protect neurons,4-7 and repair DNA damage!8
  • These synergistic effects deliver substantial, subcellular anti-aging and enhanced longevity.
  • Evidenced by studies verifying its wide cardioprotective and neuroprotective effects, PQQ beneficially modulates a host of key biomolecular functions!