Life Extension Magazine October 2012
Powerful Protection Against Cellular Aging
By Michael Downey
Scientists found in pre-clinical trials that PQQ reversed cognitive impairment caused by oxidative stress and improved performance on memory tests.21 PQQ was shown to protect against a pathologic gene protein associated with Parkinson's disease. 22 Much of the long-term neurological damage that arises after a stroke or spinal cord injury is caused by reactive nitrogen species which impose severe stresses on damaged neurons. However, PQQ was found to suppress reactive nitrogen species in induced strokes.24
PQQ also blocked a source of reactive nitrogen species following spinal cord injury.25 Researchers concluded that PQQ significantly reduces the size of the damaged area of the brain even if administered 3 hours after the stroke!27 Additionally, it provides potent protection against the inflammation and oxidative damage that results from the sudden return of blood and nutrients to tissues deprived of them by stroke.26 It would seem that PQQ should become a standard nutrient in the hospital emergency room setting for rapid administration to stroke victims.
Illustrating its cell signaling mechanism, PQQ protects neurons by modifying a key receptor site within our brain's neurotransmitter system.28,29 This inhibits excitotoxicity, a response to long-term over-stimulation of neurons that is associated with many neurodegenerative diseases and seizures.30-32
PQQ was shown to block neurotoxicity induced by other toxins, including mercury, a factor suspected to play a role in the development of Alzheimer's disease.5,33
Accumulating research indicates that PQQ serves as an intervention in Alzheimer's and Parkinson's disease—blocking development, and oxidative effects, of both the amyloid beta protein associated with Alzheimer's and the alpha-synuclein protein associated with Parkinson's, before they can cause damage.34-37
PQQ has been observed to deliver substantial cognitive benefits, including improved memory and attention.9,38 It activates the manufacture and release of an important, neuro-protective, nerve growth factor.38 Scientists tested PQQ's cognitive effects in a double-blind, placebo-controlled clinical trial conducted on humans. In this study of healthy individuals ranging from 45 to 65 years of age, 20 mg a day of PQQ produced clear improvements on standard tests of greater cognitive function. Also, the PQQ test group scored two-fold higher on memory tests than the control group.9
Scores were dramatically higher for a third group that received 300 mg per day of CoQ10 along with their 20 mg of PQQ. This underscores the powerful cognitive benefits of supplementation with agents shown to be involved in mitochondrial energy production.9
Through its broad cell signaling activity, PQQ (pyrroloquinoline quinone) modulates the many pathways of aging!
Scientific findings indicate that PQQ-enhanced signaling stimulates mitochondrial biogenesis,1-3 boosts cellular metabolism,1, improves cognitive performance and protects neurotransmitters, 4-7 and repairs DNA!8
Together, these mechanisms support subcellular anti-aging and promote longevity.
Studies have shown that PQQ beneficially modulates biomolecular functions that result in substantial heart and brain defense. As one example, scientists found that PQQ helped produce remarkable reversal of cognitive decline in aging humans!9
If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027.