Life Extension Magazine

Life Extension Magazine July 2012

Report

Halt the Auto-Immune Attack of Arthritis

By Michael Downey

Halt the Auto-Immune Attack of Arthritis

By the time people reach age 65, a startling 80% show X-ray evidence of osteoarthritis1—the most frequent cause of musculo-skeletal disability worldwide.1,2

Most doctors consider osteoarthritis and rheumatoid arthritis to be progressive and incurable. Side effect prone drugs only transiently soften pain and have no long-term impact on the disease itself.3,4

Conventional medical wisdom mistakenly believed that in contrast to rheumatoid arthritis—which results from an autoimmune attack on joints—osteoarthritis was simply the result of age-related “wear-and-tear.”

However, scientists now understand that, in both of these conditions, an inflammatory immune system attack on joint compounds can be triggered by exposed collagen.5

This article is about undenatured type II collagen, which has a unique molecular structure that interferes with damaging inflammation responses and helps to retrain the immune system.

Studies show that exposure to small amounts of type II chicken collagen can inhibit immune overreaction to exposed collagen proteins, substantially reducing the pain and disability of osteoarthritis4,6-8 and rheumatoid arthritis.9-12 In one study, an unheard-of 14% of patients taking undenatured type II collagen experienced complete remission of their rheumatoid arthritis!9

A unique formulation of undenatured type II collagen, UC-II®, was found in controlled studies to significantly reduce pain and increase function in arthritic dogs,6,7,13,14 horses,8 and humans.4

As you’ll learn, pain scores for osteoarthritis patients taking UC-II® decreased—in just 90 days—by a remarkable 40%!4

A New Understanding of Osteoarthritis

A New Understanding of Osteoarthritis

Cartilage, the shock-absorbing substance that lines our joints and allows them to slide smoothly, is comprised largely of a protein known as collagen. Minor damage to cartilage exposes small fibers of collagen that trigger rheumatoid arthritis—and osteoarthritis as well.

Until recently, conventional medical thinking held that these two forms of arthritis involve different pathologies.

Only rheumatoid arthritis was recognized as an inflammatory immune process—where the body’s oversensitive immune system attacks the body’s own tissues, in this case the joint linings and cartilage.

By contrast, osteoarthritis was believed to be an unavoidable result of the simple wear-and-tear of age and repeated use on joint cartilage and bone. It was assumed that joint-cushioning cartilage simply wore away, leaving the friction of increasingly painful scraping and inflammation.

The assumption that osteoarthritis is the degeneration of cartilage may have stemmed largely from the fact that this form of arthritis arises typically in the later years of life; and the number of minor cartilage traumas that can spark an immune response tend to increase as the water content of cartilage is reduced—which is indeed, age-related.

So, osteoarthritis has long been assumed to be an inevitable and incurable consequence of aging. In recent years, research has increasingly shown that immune mediated joint inflammation plays a large role in the development and perpetuation of osteoarthritis. This new understanding of the underlying cause of osteoarthritis offers new avenues for medical intervention and has even brought forth the possibility of a cure!

New research shows that the underlying pathology behind osteoarthritis is the triggering of an inflammatory immune response—similar to rheumatoid arthritis. The end result—for both forms of arthritis, scientists now realize—is activation of “killer” T-cells by exposed collagen, destruction of joint surfaces, and the accompanying pain and impaired function.9,15

For the first time, this establishes osteoarthritis as a disease progression that is not inevitable—and opens the door to the possibility of a single intervention to modulate the abnormal immune response behind both of these types of arthritis.

So let’s take a look at how scientists now see the development of osteoarthritis, and how we can re-educate the immune system to halt the progression of both types of arthritis—and reverse it!

The Immune System Cause of Joint Disease

Joints take a beating over time, with those in the weight-bearing lower half of our bodies taking the heaviest punishment. Small traumas to cartilage occur at all ages, but go unnoticed in younger individuals. In time, these traumas result in exposed fibers of collagen, a cartilage component.16

And that’s the early silent signal for a devastating chain of events.

Normally sealed off from the immune system, newly exposed microscopic collagen fibers are now mistaken as “foreign” cells.17

The body’s alarm goes off indicating a foreign invasion that triggers a complex and destructive interplay known as the complement cascade. An army of “killer” T-cells is sent to the joint, followed by the release of inflammatory cytokines, which in turn draw in more “killer” T-cells.17,18

This culminates in the release of a cell-destroying protein cluster called the membrane attack complex, or MAC.19 These MAC proteins bind themselves to cartilage-producing cells, causing them to secrete complement-component proteins, as well as other inflammatory chemicals and enzymes. Together, these secreted compounds proceed to chew up the matrix of cartilage occupying the spaces between cells.18

But the attack doesn’t end there!

Researchers found that as cartilage fibers are destroyed by the immune system, the destroyed cells release various byproducts, including fibromodulin. These damaging breakdown products directly reactivate the complement cascade—driving a vicious and continuing cycle of joint-tissue damage.18

Small, surface fibers trigger the initial immune response. Then the secondary cycle of trigger-damage eventually eats away the healthy cartilage within the joint—creating the pain, friction, and grinding known as osteoarthritis.19

To prove this chain of events is the origin of osteoarthritis, mice were bioengineered so that they lacked a key protein, without which the complement cascade (a specific set of events that set off an immune response) cannot be triggered. Following a cartilage tear—which in this special case did not trigger the normal immune-attack cascade—the mice maintained their ability to walk normally and did not suffer any osteoarthritic or immune reaction.18

Rheumatoid arthritis occurs when the immune system mistakenly identifies exposed cartilage—or other joint elements such as synovial fluid or the synovial membrane—as “enemies.”9 An inflammatory response ensues that is considered to be high-grade, which is why rheumatoid arthritis is categorized as a true autoimmune disease. As in osteoarthritis, exposed collagen triggers the complement cascade, a cyclical attack that eventually destroys the joint surfaces and normal function.

Now aware that both osteoarthritis and rheumatoid arthritis are substantial immune reactions triggered by exposed collagen,219,20 scientists sought ways to target the common immune origin of these joint-destroying diseases.

The ideal prevention would be to re-educate the immune system to differentiate between exposed collagen fibers and foreign bodies. This would inhibit overreaction to proteins normally found in joint cartilage, and prevent immune-mediated attacks on the joints.

Fortunately, a number of studies have shown that a form of a natural collagen does just that!

Protect Your Joint Health with Undenatured Type II Collagen
A New Understanding of Protect Your Joint Health with Undenatured Type II Collagen
    • Until recently, osteoarthritis was simply considered to be the mechanical wearing down of cartilage with use and aging, treatable only with risky and ineffective NSAIDs and immune suppressants.
    • Scientists have now learned that osteoarthritis—like rheumatoid arthritis—is an abnormal immune response to exposed collagen fibers in joint cartilage.
    • Oral introduction of type II collagen desensitizes the immune system to collagen fibers, preventing the inflammatory response that leads to further joint destruction.
    • This unique intervention works by activating the natural pathway of induced oral tolerance—“short-circuiting” both osteoarthritis and rheumatoid arthritis!
    • Controlled clinical studies have confirmed that undenatured type II collagen uniquely inhibits arthritic joint pain, swelling, and loss of function—by blocking the disease process in both rheumatoid and osteoarthritis.

Short-Circuit Arthritis—at its Root

Because arthritis has been considered impossible to cure, standard medical treatment has focused on drugs for inflammation and pain and in some cases, immune suppressants. These pharmaceuticals include NSAIDs such as ibuprofen (Motrin®), and corticosteroids such as prednisone. They substantially increase the risk of life-threatening disorders, including obesity, kidney disease, diabetes, heart disease, and stroke.21-24 And yet, they only blunt symptoms while having no impact on the origin of the disease itself.4

So, scientists have long sought ways to short-circuit the immune response to exposed collagen.

Then, researchers came across the surprising finding that something in chicken soup exerted an anti-inflammatory activity, protecting sites of inflammation from attack. 25

When scientists later investigated type II chicken collagen, they discovered its potential to act along natural immune pathways to induce tolerance to exposed collagen.

At that time, osteoarthritis was still seen as simply the mechanical wearing down of cartilage with use and aging. So, chicken collagen was initially tested only on the known autoimmune joint condition, rheumatoid arthritis.

In a randomized, double-blind study of the effect of type II chicken collagen on 60 patients with active rheumatoid arthritis, the number of swollen and tender joints decreased in the collagen group, but not in the placebo group—within just 3 months. However, the study team observed another dramatic finding: an unheard-of 14% of those patients receiving type II chicken collagen had a complete remission of their rheumatoid arthritis!9

These findings for type II chicken collagen were confirmed with similar results in a larger trial of 274 patients with active rheumatoid arthritis.10

Scientists tested oral type II collagen on patients with juvenile rheumatoid arthritis, an especially aggressive form of this disease that begins in childhood. In just 12 weeks, 80% of the patients in the type II collagen group responded to treatment with an average reduction of 61% in the number of swollen joints, and an average reduction of 54% in the number of tender joints.11

Eventually, researchers conducted a conclusive phase III clinical trial on over 500 rheumatoid arthritis patients, which was published in the journal Arthritis Research & Therapy in 2009. They found that supplementing with type II chicken collagen resulted in reduced disease activity and beneficial effects—exerted specifically, in the words of the study authors, “through inducing oral tolerance.”12

As it became increasingly apparent that osteoarthritis—like rheumatoid arthritis—is an immune disorder, scientists began testing type II chicken collagen on this most prevalent form of joint disease.

Let’s examine the results of these breakthrough studies.

How UC-II® Induces Oral Tolerance

Researchers found that normally processed collagen exhibited no bioactivity and would not induce oral tolerance.15 Only a specific form of collagen, with its unique molecular structure, will retrain the immune system not to overreact to exposed collagen fibers. To understand this difference, let’s examine how oral tolerance is induced.

T-cells are in part, immune system watchdogs, constantly assessing the three-dimensional structure of proteins they encounter in order to distinguish between harmless “self” proteins and potentially deadly “foreign” proteins.27

If T-cells are exposed in the blood to a new protein structure—such as an unrecognized protein on separated collagen fiber—they react violently and trigger an inflammatory response to destroy what is presumed to be a disease-causing invader.28

And that deadly inflammatory attack is extended to any other collagen molecules that are subsequently encountered by the T-cells—including intact collagen in cartilage in the joint.

In fact, injecting collagen into animals is the standard procedure to create an animal model of arthritis for experiments. It sensitizes the T-cells in their blood to the collagen protein, which results in inflammation in the animal’s joints where the circulating T-cells encounter rich supplies of identical molecular structures.29 The inflammatory result is arthritis.

However, scientists have learned that it is possible to teach T-cells that the collagen molecule is a friend rather than a foe.

Rich collections of immune tissue are located in the lower end of the small intestine. Called Peyer’s patches, they act as “training centers” for the immune system, exposing T-cells to a vast variety of molecular shapes among the natural components in the food we eat. This desensitizes T-cells to new foods to avoid constant inflammatory or allergic reactions. In other words, this is the area that induces tolerance.30

Native collagen introduced into the digestive tract—rather than directly into the bloodstream—can “educate” T-cells to ignore collagen fibers when they are encountered in the joints.31 In scientific terms, the result is “induced specific oral tolerance.”32,33

This oral tolerance to collagen powerfully suppresses joint inflammation, as has been shown in numerous studies.32-35

But to induce tolerance to exposed joint collagen, the orally introduced product must be type II collagen—the same form of collagen found in the cartilage matrix—and must have the exact same three-dimensional structure.

Typical commercial processing causes collagen to become denatured. Its normal helical shape uncoils and it has as a slightly, but crucially, altered three-dimensional structure. Denatured collagen does not induce oral tolerance.32

However, undenatured type II chicken collagen retains its molecular structure, allowing it to induce oral tolerance.

Scientists found that—even in small doses—orally administered undenatured type II chicken collagen inhibits the killer T-cell attack.15,34

UC-II® is a proprietary formulation of undenatured type II chicken collagen, derived from chicken sternum cartilage, a rich source of natural collagen. UC-II® retains the original helical molecular structure of joint collagen.27 This allows the T-cells in Peyer’s patches to develop tolerance to exactly the same molecular shape as exposed collagen encountered in the joints—which will now be recognized as “self,” not “foreign,” molecules.

This unique molecular composition of UC-II® has been shown to be robust. This enables UC-II® to survive passage through the harsh conditions of the stomach and small intestine, so that it arrives finally at Peyer’s patches with its molecular structure intact.27

Studies verify that when undenatured type II collagen is introduced into the digestive tract, it induces oral tolerance to the exposed collagen inside the joint and suppresses rheumatoid and osteoarthritis.