Life Extension Magazine February 2014
Targeting Appetite Hormones To Prevent Food Cravings
By Michael Downey
Animal Data Supports Lamon Extract
The early studies on the Italian Lamon variety Borlotto bean extract were conducted on laboratory animal models.
Different rat groups were supplemented with very high doses of Lamon variety bean extract and then provided with access to regular food pellets, a starch-enriched diet, and a highly palatable chocolate-flavored beverage.23 The results showed that there were decreases in blood glucose levels, food intake, and body weight gain, all varying by the dose of Italian Lamon variety Borlotto bean extract.23
In one of these experiments, scientists pretreated rats with a drug that interferes with receptors for the appetite-suppressing hormone CCK. The drug blocked Lamon bean extract’s food reduction effect, demonstrating that Lamon extract works in part by modulating CCK signaling.23
To learn more about the hunger-reducing effects of Italian Lamon variety Borlotto bean extract, scientists conducted additional studies. Rats were trained to press a lever to receive as much of a chocolate-flavored beverage as they wished.35 Then Lamon variety bean extract was administered in differing dosage ranges. In a dose-dependent manner, Lamon bean extract reduced lever-pressing by up to 40% indicating that the rats had a sense of satiety and did not want more of the chocolate-flavored beverage.35
This finding was repeated in two almost-identical studies,one of which also found an up to 30% reduction in food intake—a reduction that persisted for a full 24 hours!36,37
This appetite-suppressing effect was further tested on obese rats. They were weighed after each of three separate rounds of 5-day treatment periods followed by a 20-day washout period.26 After each treatment period, in a dose-dependent manner, the different doses of Italian Lamon variety Borlotto bean extract reduced daily food intake by an average of 20-35% and resulted in reduced body weight.26
When rats are fed carbohydrates, they experience blood sugar spikes—just as humans do. Researchers reported that the Italian Lamon variety Borlotto bean extract effectively blocks absorption of carbohydrates in animals by inhibiting the alpha-amylase enzyme.26
In one experiment on after-meal glucose response, scientists first put obese rats through a food-deprivation period. Then, they were given different doses of the Italian Lamon variety Borlotto bean extract and immediately allowed access to a fixed amount of starch-enriched chow.26 Testing after the meal showed that in a dose-dependent manner, the Italian Lamon variety Borlotto bean extract suppressed carbohydrate-induced after-meal glucose spikes.26
The doses used in these rat studies were far higher than needed in the successful human clinical trials. This helped demonstrate the safety of the Italian Lamon variety Borlotto bean extract. The impressive human studies only required 100 mg of the Italian Lamon variety Borlotto bean extract taken two times daily.3
Inhibiting Carbohydrate Absorption
Appetite hormones are not the only factor in weight gain. Excess carbohydrate calories in the modern Western diet undermine the best efforts to maintain healthy levels of body weight.38
Excess blood glucose leads to increased insulin—and increased insulin contributes to greater difficulty burning stored body fat as fuel.39 It is also involved in the body storing more excess carbohydrate calories as unsightly fat.39 Rapid sugar absorption contributes to after-meal glucose surges, impaired sugar control, and sharply increased disease risk.
The good news is that in addition to its ability to rebalance appetite hormones, Italian Lamon variety bean extract also impedes the enzyme alpha-amylase which breaks down dietary starch into simple sugars that are rapidly absorbed in the small intestine.3,23
Blocking alpha-amylase inhibits the breakdown of starches and slows the rate at which free sugars are absorbed, thereby blunting glucose spikes.26 This provides a practical approach to help lower glucose levels, improve age-related markers of health, and regain glycemic control.
Italian Lamon variety Borlotto bean extract helps counteract undesired weight gain through two distinct mechanisms: it rebalances appetite signaling hormones and it inhibits excess carbohydrate absorption.
Since obesity involves a higher mortality risk than being of normal weight,40 successful weight loss can be a matter of life and death.
But disordered appetite hormones sabotage weight loss by causing chronic hunger, a reduced feeling of satiety, and greater cravings for unhealthy food choices. The most effective option to regulate appetite hormones is gastric bypass surgery—which is costly, uncomfortable, and substantially risky.
Clinical studies now demonstrate that a proprietary extract from the Italian Lamon variety Borlotto bean is a safe, effective nutritional supplement that modulates ghrelin and other appetite hormones, effectively blocking hunger while increasing feelings of food satisfaction and fullness.2,3,23-25
Italian Lamon variety Borlotto bean extract also inhibits the enzyme (alpha-amylase) that converts carbohydrates into sugar.3,23 This impedes the after-meal glucose surge that has been implicated in increased risks of a number of degenerative conditions.29-34
Based on clinical trial data, this new Italian Lamon variety Borlotto bean extract may help aging individuals achieve healthy body weight and optimize glucose control, thereby reducing disease risks, improving appearance, and boosting longevity!
If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027.
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