Life Extension Magazine June 2014
As We See It
By William Faloon
Misinterpretation Of The Massachusetts General Hospital Study
The doctors who conducted the study at Massachusetts General Hospital extolled their findings about the adverse effects seen in men prescribed the absurdly high dose of anastrozole.
They noted the increased percentage of abdominal fat as well as decreased sexual desire and erectile function seen in their estrogen-deficient study subjects. These doctors extrapolated that since abdominal fat mass is associated with diabetes and metabolic syndrome, that the marked increase in visceral fat seen in men prescribed high-dose anastrozole could portend increases in cardiovascular disease.
The problem is that estradiol was artificially suppressed down to levels not seen in the real world. It thus is not surprising that these men with virtually no estrogen suffered unwanted side effects.
The doctors who performed this study concluded that men need sufficient levels of estrogen, as well as testosterone, to stay healthy. The media made it appear as if a major discovery had occurred, i.e. a newly found role for estrogen in males. This is not a new finding!
Scientists long ago identified men's biological requirements for estrogen, and published studies of aging men clearly demonstrate the lethal impact when estradiol levels are too high or too low.43,69
The implication from this study's findings was that doctors should use caution when prescribing estrogen-suppressing drugs to their male patients. Nowhere do they mention that the study subjects were grossly overdosed on anastrozole to the point that estradiol levels dropped to virtually nonexistent levels.
In today's sound bite environment, practicing physicians will be even less likely to prescribe the proper dose of anastrozole (1 mg a week) to men whose estradiol levels are over 30 pg/mL. At Life Extension, we sometimes see aging men with estradiol levels over 60 pg/mL. These men are in urgent need of aromatase-inhibition using the proper dose of anastrozole, yet their doctors might erroneously refuse to prescribe it because they will recall the misinterpretation of this study emanating from esteemed Massachusetts General Hospital.
On a positive note, doctors at Massachusetts General Hospital stated in their concluding remarks that some of the deleterious effects of aging may be related to changes in testosterone and estrogen levels that "may be preventable with appropriate replacement."
At least the medical authorities are recognizing that aging men do indeed require testosterone and estrogen.
Our Early Battles With Medical "Authorities"
When Life Extension first recommended that aging men restore their testosterone to youthful levels, a firestorm of criticism erupted.
The medical establishment proclaimed that by interfering with the natural decline in testosterone secretion, men risked all kinds of terrible fates. When Life Extension members asked their doctors for testosterone prescriptions, they ran into objections such as,"I don't prescribe steroids," "testosterone causes heart attacks," and "testosterone causes prostate cancer."
We countered these criticisms with hundreds of scientific citations showing that testosterone deficiency is an underlying cause of many age-related diseases. We also demonstrated that none of the paranoid fears about natural testosterone had ever been substantiated.
Low Testosterone Increases Prostate Cancer Risk
Fear of prostate cancer was the leading reason why aging men historically shied away from restoring their testosterone.
To dispel this concern, Life Extension analyzed every published study in the 1990s and found there was no basis for asserting that testosterone causes prostate cancer.86-91
Our observations from the thousands of blood tests we perform each year for members corroborate this. What we found is that men with low testosterone appear to be more likely to contract prostate cancer.
In the book Testosterone for Life, authored by Harvard researcher Abraham Morgentaler, MD, the misleading notion about testosterone causing prostate cancer was exposed in meticulous detail.
Dr. Morgentaler dropped a bombshell on the medical establishment in 2008 showing that men with low testosterone levels have an increased percentage of prostate cancer-positive biopsies.92 This and other findings have led to the record number of aging men being prescribed natural testosterone today.
Critical Importance Of Blood Testing
Today's conventional physicians prescribe blood tests to check glucose, cholesterol, and triglycerides, but rarely check their male patients' testosterone and estradiol levels.
When looking at the higher mortality rates associated with imbalances of these critical hormones, it becomes strikingly apparent that a significant number of heart attacks, strokes, bone fractures, and other degenerative diseases are easily preventable.
One reason these hormone blood tests are not normally prescribed is their high retail cost, and the fact that insurance companies may not routinely pay for them.
As a member of the Life Extension Foundation®, you don't have to be victimized by conventional medical ignorance, high prices, or insurance company indifference.
Take Charge Of Your Health
An all-inclusive blood test panel that includes total testosterone, free testosterone, estradiol, and PSA can be very expensive at commercial labs. Life Extension members obtain these tests at a huge discount.
If your blood test result reveals imbalanced testosterone and/or estradiol, you are in a position to initiate immediate corrective action. Not only can restoring youthful hormone balance save your life, but men (and women) often experience an enhancement in their quality of life after their hormones are adjusted to optimal ranges.
A description of the Male and Female Blood Test Panels can be found above. As you'll readily see, these panels contain many important tests (such as 25-hydroxyvitamin D, homocysteine, C-reactive protein, and DHEA) that mainstream doctors seldom check for.
When you order these tests, a requisition form is sent listing blood drawing stations in your local area. Appointments are usually not necessary, meaning you can have your blood drawn at your convenience. Results are mailed (or emailed) to you usually within five days.
Annual Blood Test Super Sale
High prices charged by commercial labs for comprehensive blood testing preclude most people from having them done. The tragic result is that aging humans needlessly suffer the ill effects of hormone imbalances.
Life Extension breaks down these price barriers by offering Male or Female Blood Test Panels at the lowest prices anywhere. Once a year, we discount the popular Male and Female Blood Test Panels to only $199-far less than what commercial labs charge.
The Blood Test Super Sale ends June 2, 2014, so please order your requisition kit to take advantage of these extra discounted prices. You can have your blood drawn any time after receiving your requisition kit.
The results of your blood tests are rapidly sent directly to you. If you have any questions, you are welcome to call our health advisor helpline.
Annual blood testing is the single most effective method of detecting abnormalities before they lead to serious illness or death. A call to 1-800-208-3444 is all you have to do to order these comprehensive tests at extra discounted prices.
For longer life,